Influence of physical activity and weight loss on brain plasticity

体力活动和减肥对大脑可塑性的影响

• 批准号: 8399894
• 负责人: Kirk I Erickson
• 金额: $ 42.76万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-15 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8399894
• 关键词: Address; Adolescence; Adult; Adverse effects; Affect; American; Area; Attenuated; Biological Markers; Blood; Blood flow; Body Composition; Body Weight decreased; Brain; Brain imaging; Cardiac; Cerebrovascular Circulation; Childhood; Cognition; Cognitive; Control Groups; Data; Deterioration; Development; Diet; Diet Habits; Dorsal; Dose; Dual-Energy X-Ray Absorptiometry; Education; Energy Intake; Epidemic; Exercise stress test; Exhibits; Figs - dietary; Functional disorder; Funding; Future; Glucose; Growth; Health; Impulsivity; Individual; Inflammation; Inflammatory; Insulin; Insulin Resistance; Intervention; Left Ventricular Mass; Link; Literature; Magnetic Resonance Imaging; Measures; Mediating; Mental Depression; Metabolic; Metric; Molecular; Mood Disorders; Moods; Neurocognitive; Neurophysiology - biologic function; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Outcome Measure; Overweight; Parents; Participant; Pathway interactions; Physical activity; Physiologic pulse; Physiological; Preparation; Prevalence; Problem behavior; Process; Public Health; Recovery; Recruitment Activity; Relative (related person); Rest; Rewards; Risk; Risk Factors; Sampling; Structure; Techniques; Testing; Time; United States; United States National Institutes of Health; abdominal fat; arm; base; career; cost; cost effective; executive function; fitness; gray matter; improved; inflammatory marker; innovation; neuroimaging; neurological pathology; physical conditioning; programs; relating to nervous system; response; reward processing; weight loss intervention; white matter; Address; Adolescence; Adult; Adverse effects; Affect; American; Area; Attenuated; Biological Markers; Blood; Blood flow; Body Composition; Body Weight decreased; Brain; Brain imaging; Cardiac; Cerebrovascular Circulation; Childhood; Cognition; Cognitive; Control Groups; Data; Deterioration; Development; Diet; Diet Habits; Dorsal; Dose; Dual-Energy X-Ray Absorptiometry; Education; Energy Intake; Epidemic; Exercise stress test; Exhibits; Figs - dietary; Functional disorder; Funding; Future; Glucose; Growth; Health; Impulsivity; Individual; Inflammation; Inflammatory; Insulin; Insulin Resistance; Intervention; Left Ventricular Mass; Link; Literature; Magnetic Resonance Imaging; Measures; Mediating; Mental Depression; Metabolic; Metric; Molecular; Mood Disorders; Moods; Neurocognitive; Neurophysiology - biologic function; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Outcome Measure; Overweight; Parents; Participant; Pathway interactions; Physical activity; Physiologic pulse; Physiological; Preparation; Prevalence; Problem behavior; Process; Public Health; Recovery; Recruitment Activity; Relative (related person); Rest; Rewards; Risk; Risk Factors; Sampling; Structure; Techniques; Testing; Time; United States; United States National Institutes of Health; abdominal fat; arm; base; career; cost; cost effective; executive function; fitness; gray matter; improved; inflammatory marker; innovation; neuroimaging; neurological pathology; physical conditioning; programs; relating to nervous system; response; reward processing; weight loss intervention; white matter

DESCRIPTION (provided by applicant): This application proposes to add a neuroimaging arm to an NIH funded 12-month diet and physical activity intervention. Obesity is currently at epidemic proportions in the United States, affecting over 1/3rd of American adults. Impaired cognitive and brain function - manifested as mood disorders, impulsivity, and an increased risk for neurological pathology - are often unrecognized consequences of obesity. These consequences are especially unsettling in view of the increased prevalence of obesity during childhood and adolescence, when the education, intellectual growth, and the preparation for future career seeking are at its peak. Hence, it is a public health imperative to rigorously investigate the effects of obesity on neurocognitive functions and to explore the potential for weight loss to restore cognitive and brain function. The parent study has three groups: diet only (DIET), diet + moderate physical activity (MOD-PA), diet + high physical activity (HIGH-PA) and will be collecting a myriad of outcome measures including aortic pulse wave velocity, inflammatory markers, glucose and insulin, abdominal adiposity and body composition using dual-energy X-ray absorptiometry, cardiorespiratory fitness using a graded exercise test, accelerometry measured physical activity, and energy intake. In addition to the subjects collected in the parent study we will collect a group of no-contact control (CON) participants for both reliability and comparison purposes. Therefore, by adding brain imaging to this intervention, our proposal reflects a cost effective and innovative approach to investigate links between physical activity, weight loss, brain integrity, metabolic outcomes, and cognitive processing and offers an opportunity to collect data on brain health with minimal additional costs. Testing these links could transform the way that brain-body associations are considered when assessing the risk for brain dysfunction or treating obesity related behavioral problems. Our main aims include: Aim 1. To examine whether a 12-month physical activity and weight loss intervention on overweight and obese adults increases cortical volume and improves microstructural white matter integrity, Aim 2: Examine how increased physical activity and weight loss can change the functional dynamics of the brain as assessed by both task-related neural responses, cerebral blood flow, and resting state brain connectivity, Aim 3. Link the changes in brain integrity, function, and connectivity with intervention-induced changes in physiological measures of metabolic and inflammatory molecular pathways. Our project represents the first attempt to associate weight loss in a long-term intervention to changes in brain networks. It is highly innovative, cost-effective, and will add significantly to the scientifc literature. By leveraging an existing NIH funded program and by focusing on neuroimaging outcomes with a skilled and productive team of experts in both weight loss interventions and cutting-edge neuroimaging techniques, we will be able to address unanswered questions that have important theoretical and translational implications for obesity and brain health. PUBLIC HEALTH RELEVANCE: In this study, we are examining the capacity for a 12-month physical activity and weight loss intervention to enhance brain integrity in a sample of overweight and obese adults. Our project represents the first attempt to link weight loss in a long-term intervention to changes in brain networks.

描述（由申请人提供）：本申请建议将神经影像臂添加到NIH资助的12个月饮食和体育锻炼干预措施中。肥胖症目前在美国的流行比例，影响了1/3以上的美国成年人。认知和大脑功能受损 - 表现为情绪障碍，冲动性和神经病理学的风险增加 - 通常是肥胖的后果。考虑到童年和青春期肥胖症的增加，教育，智力增长以及为未来的职业寻求寻求的准备就达到顶峰时，这些后果尤其令人不安。因此，必须严格研究肥胖对神经认知功能的影响，并探索体重减轻以恢复认知和大脑功能的可能性，这是一种公共卫生。父母研究有三组：仅饮食（饮食），饮食 +中等体育锻炼（MOD-PA），饮食 +高体育锻炼（高-PA），并将收集无数的结局指标，包括使用Diual-Enerergy X-Ray Pray ray Protifiorpitiorpitiorpitiorpitiorpitiorpitiorpitiorpitiorpitiorpitiorpitiorpitiorpitiemry，包括主动脉脉搏波速度，炎症和胰岛素和胰岛素和身体组成加速度计测量的体育活动和能量摄入。除了父母研究中收集的受试者外，我们还将为可靠性和比较目的收集一组无接触对照（CON）参与者。因此，通过将大脑成像添加到此干预措施中，我们的建议反映了一种具有成本效益和创新的方法，可以研究体育活动，体重减轻，大脑完整性，代谢结果和认知处理之间的联系，并提供了一个机会，以最低的额外成本收集有关大脑健康数据的机会。测试这些链接可以改变评估脑功能障碍或治疗肥胖相关行为问题的风险时考虑脑体关联的方式。我们的主要目的包括：目标1。检查超重和肥胖的成年人的12个月体育活动和体重减轻干预是否会增加皮质体积并改善微结构白质的完整性，目标2：检查体育活动增加和体重减轻如何改变大脑的功能动态，以评估由任务相关的神经血液流动，脑部整合和恢复性，链接，链接，链接，链接，链接，链接，链接，链接，链接，链接，链接，链接，链接，链接，连接，连接，连接，连接。干预引起的代谢和炎症分子途径的生理量度变化。我们的项目是将体重减轻与长期干预与大脑网络变化相关联的首次尝试。它具有很高的创新性，具有成本效益，并将大大增加科学文献。通过利用现有的NIH资助计划，并专注于通过在减肥干预措施和尖端的神经影像学技术方面与熟练和富有成效的专家团队的神经影像成果，我们将能够解决具有重要理论和翻译对肥胖和脑部健康的重要理论和翻译意义的问题。 公共卫生相关性：在这项研究中，我们正在研究进行12个月的体育活动和减肥干预措施的能力，以增强超重和肥胖成年人样本中的大脑完整性。我们的项目是将长期干预中的体重减轻与大脑网络变化联系起来的首次尝试。