The National Center for Microscopy and Imaging Research, a Community-wide Scientific Resource

国家显微镜和成像研究中心，社区范围的科学资源

基本信息

批准号：
10400847
负责人：
Mark H Ellisman
金额：
$ 62.91万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-01 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10400847
关键词：
Advisory Committees Aging Biological Biomedical Research Biomedical Technology California Cells Communities Complex Cryoelectron Microscopy Data Development Disease Elements Evaluation Fruit Funding Goals Guidelines Health Heart Home Image Imaging technology Infrastructure Institutes Institution Light Macromolecular Complexes Maintenance Methods Microscopic Microscopy Mission Modeling Molecular Probes Molecular Structure National Institute of General Medical Sciences Organ Performance Physiological Processes Preparation Procedures Process Recovery Research Research Personnel Research Project Grants Research Support Resolution Resource Allocation Resources Services Specimen Structure Structure-Activity Relationship Surface Techniques Technology TimeLine Tissues Universities Ursidae Family base community engagement computerized tools cost insight instrumentation macromolecule microscopic imaging novel operation particle programs quality assurance reconstruction technology development technology research and development tool

项目摘要

PROJECT SUMMARY AND ABSTRACT The National Center for Microscopy and Imaging Research (NCMIR) at UC San Diego is a vital and unique NIGMS supported biomedical technology development research resource (BTRR). NCMIR is completing its 31st and final funded year of continuous operation and is thereby ineligible for renewal under new guidelines governing the P41 program. With this proposal, we request stabilizing support to help ease the transition of the Center to independent sustainability and to allow for the ordered completion of the resource's existing pool of supported biomedical research projects. NCMIR's mission is to advance the coordinated use of specialized molecular probes, novel specimen preparation methods, leading-edge microscopy and imaging technologies, and scalable computational tools to help investigators traverse difficult to navigate spatial and temporal scales, deliver new insight into multiscale structure/function relationships, and provide a fundamental understanding of the macromolecular mechanisms underlying many topics in health, disease, and aging. In transitioning the resource to a self-sustaining community-wide scientific resource, we provide details of our `Operation and Maintenance Plan' to govern how the resource supports ongoing research users, prepares developed technologies for broad dissemination, and modifies its approach to community engagement to communicate offered technologies, services, and resources. We further establish a `Transition Plan' to scale existing cost- recovery processes and put into place new mechanisms to stabilize support for the operation of the resource, buttressed by commitments from stakeholders within our home institution at the University of California, San Diego and the greater La Jolla mesa. Last, we establish an `Evaluation Plan' to quantify and assess resource performance and impact on the community, putting forth both Short-term Internal Metrics, to optimize resource utilization and make ongoing improvements, and Long-term Objective Metrics, to gauge overall impact on the scientific community.

项目概要和摘要加州大学圣地亚哥分校的国家显微镜和成像研究中心 (NCMIR) 是一个重要而独特的中心 NIGMS 支持生物医学技术开发研究资源（BTRR）。 NCMIR 即将完成第 31 届以及连续运营的最后资助年份，因此没有资格根据新准则进行续约管理 P41 计划。通过此提案，我们请求稳定的支持，以帮助缓解过渡期以独立可持续性为中心，并允许有序完成资源的现有池支持生物医学研究项目。 NCMIR 的使命是促进专业技术的协调使用分子探针、新颖的标本制备方法、领先的显微镜和成像技术、和可扩展的计算工具，帮助研究人员穿越难以导航的空间和时间尺度，提供对多尺度结构/功能关系的新见解，并提供对健康、疾病和衰老等许多主题的大分子机制。在转型过程中资源到一个自我维持的全社区科学资源，我们提供我们的“运营和维护计划”管理资源如何支持正在进行的研究用户，准备开发广泛传播的技术，并修改其社区参与沟通的方法提供技术、服务和资源。我们进一步制定了“过渡计划”以扩大现有成本- 恢复进程并建立新机制以稳定对资源运营的支持，得到我们所在机构加州大学圣分校利益相关者承诺的支持迭戈和更大的拉霍亚台地。最后，我们制定“评估计划”来量化和评估资源绩效和对社区的影响，提出短期内部指标，以优化资源利用率并进行持续改进，以及长期目标指标，以衡量对科学界。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Structure versus function: Are new conformations of pannexin 1 yet to be resolved?

DOI：
10.1085/jgp.202012754
发表时间：
2021-05-03
期刊：
The Journal of general physiology
影响因子：
0
作者：
Mim C;Perkins G;Dahl G
通讯作者：
Dahl G

(-)-Epicatechin induces mitochondrial biogenesis and markers of muscle regeneration in adults with Becker muscular dystrophy.

DOI：
10.1002/mus.27108
发表时间：
2021-03
期刊：
Muscle & nerve
影响因子：
3.4
作者：
McDonald CM;Ramirez-Sanchez I;Oskarsson B;Joyce N;Aguilar C;Nicorici A;Dayan J;Goude E;Abresch RT;Villarreal F;Ceballos G;Perkins G;Dugar S;Schreiner G;Henricson EK
通讯作者：
Henricson EK

cAMP/PKA pathway and mitochondrial protection in oxidative stress-induced optic nerve head astrocytes.