National Center for Microscopy and Imaging Research: A BRAIN Technology Integration and Dissemination Resource

国家显微镜和成像研究中心：大脑技术集成和传播资源

基本信息

批准号：
10334513
负责人：
Mark H Ellisman
金额：
$ 112.88万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-02-01 至 2025-12-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10334513
关键词：
3-Dimensional Achievement Actins Animal Model BRAIN initiative Behavior Biomedical Technology Brain Brain imaging Chemicals Communities Community Outreach Complement Complex Data Analyses Data Set Disease Electron Microscopy Elements Endoplasmic Reticulum Extracellular Matrix Genetic Goals Histologic Image Imaging Device Imaging Techniques Imaging technology Immersion In Situ Information Technology Investigation Label Learning Light Maps Measures Methods Microscopy Mitochondria Molecular Molecular Probes National Center for Research Resources National Institute of General Medical Sciences Nerve Tissue Neurons Neurosciences Physiological Population Preparation Process Recovery Research Research Personnel Research Project Grants Resolution Resource Sharing Resources Roentgen Rays Role Sampling Scanning Electron Microscopy Specimen Stains Structure Structure-Activity Relationship Subcellular Anatomy Techniques Technology Training Ultramicrotomy Vertebral column Vesicle Visualization Work X ray microscopy base brain cell brain research brain tissue cell type computerized tools connectome cost cryogenics cyber infrastructure data acquisition data dissemination data management data sharing deep learning imaging platform insight instrument instrumentation interest large scale data light microscopy microscopic imaging multimodal data multimodality nano novel operation preservation reconstruction relating to nervous system spatiotemporal success synaptic function tomography tool voltage

3-Dimensional Achievement Actins Animal Model BRAIN initiative Behavior Biomedical Technology Brain Brain imaging Chemicals Communities Community Outreach Complement Complex Data Analyses Data Set Disease Electron Microscopy Elements Endoplasmic Reticulum Extracellular Matrix Genetic Goals Histologic Image Imaging Device Imaging Techniques Imaging technology Immersion In Situ Information Technology Investigation Label Learning Light Maps Measures Methods Microscopy Mitochondria Molecular Molecular Probes National Center for Research Resources National Institute of General Medical Sciences Nerve Tissue Neurons Neurosciences Physiological Population Preparation Process Recovery Research Research Personnel Research Project Grants Resolution Resource Sharing Resources Roentgen Rays Role Sampling Scanning Electron Microscopy Specimen Stains Structure Structure-Activity Relationship Subcellular Anatomy Techniques Technology Training Ultramicrotomy Vertebral column Vesicle Visualization Work X ray microscopy base brain cell brain research brain tissue cell type computerized tools connectome cost cryogenics cyber infrastructure data acquisition data dissemination data management data sharing deep learning imaging platform insight instrument instrumentation interest large scale data light microscopy microscopic imaging multimodal data multimodality nano novel operation preservation reconstruction relating to nervous system spatiotemporal success synaptic function tomography tool voltage

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项目摘要

PROJECT SUMMARY/ABSTRACT This project aims to disseminate validated technologies and resources of the National Center for Microscopy and Imaging Research (NCMIR) at UC San Diego to advance the completion of strategic goals of the BRAIN Initiative. The proposed technology integration and dissemination resource will provide the neuroscience community with technical help to obtain and manage large scale data, broadening the access to and incorporation of high throughput multiscale imaging tools and leading-edge analysis strategies in their studies. Richly integrated resources will be offered, including molecular probes, imaging platforms and data analysis tools certain to enable and hasten brain research. The types of research projects we will support, include: 1) investigations requiring the traversal of spatiotemporal scales to reveal new insight and understanding of specific neural populations; 2) investigations which aim to mark and track neuronal processes and/or visualize targeted connectomes of local circuits within large volumes of nervous tissue in multiple animal models; 3) projects which seek to perform nano-histological assessment of cellular and subcellular level alterations associated with learning, physiological state, or disease; and 4) projects performing higher resolution 3D morphometric analysis of subcellular underpinnings of function, with particular emphasis on synaptic function as influenced by subcellular constituents. This new center will leverage an administrative framework and information technology cyberinfrastructure which is already in place and has been refined over many years. In addition to providing a management structure, this framework includes a community outreach, project review, selection, and onboarding process refined and long practiced by the PI (and the assembled team). Additional mechanisms for tool/technology dissemination and training, data management and sharing, and mechanisms for cost-recovery and long-term sustainability will also be leveraged and expanded so as to maximize the reach and impact of our technologies and resources.

项目摘要/摘要该项目旨在传播国家显微镜中心的经过验证的技术和资源圣地亚哥分校的成像研究（NCMIR），以促进大脑战略目标的完成倡议。拟议的技术集成和传播资源将为神经科学提供通过技术帮助，社区获得和管理大规模数据，扩大了对和的访问将高吞吐量的多尺度成像工具和领先分析策略纳入其研究。将提供丰富的集成资源，包括分子探针，成像平台和数据分析工具确定能够实现和促进大脑研究。我们将支持的研究项目类型包括：1）需要进行时空尺度遍历的调查，以揭示新的见解和对特定的理解神经种群； 2）旨在标记和跟踪神经元过程和/或可视化目标的调查多种动物模型中大量神经组织中局部电路的连接； 3）项目寻求对与相关的细胞和亚细胞水平变化进行纳米历史评估学习，生理状态或疾病； 4）执行较高分辨率的项目3D形态计量分析功能的亚细胞基础，特别着重于突触功能亚细胞成分。这个新中心将利用行政框架和信息技术网络基础设施已经到位，并且已经进行了多年的改进。除了提供管理结构，此框架包括社区外展，项目审查，选择和入职 PI（和组装团队）进行了完善和长期实践。其他机制工具/技术传播和培训，数据管理和共享以及成本恢复的机制长期的可持续性也将得到杠杆和扩展，以最大程度地提高我们的影响力和影响技术和资源。