Biostatistics, Analytical Support and Evaluation Shared Resource (BASE)

生物统计学、分析支持和评估共享资源 (BASE)

• 批准号: 10394815
• 负责人: GANG LI
• 金额: $ 36.21万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-12-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10394815
• 关键词: Adherence; Amendment; Applications Grants; Area; Award; Basic Science; Bioinformatics; Biometry; Cancer Center; Cancer Center Support Grant; Catchment Area; Child; Clinical; Clinical Cancer Center; Clinical Data; Clinical Trials; Clinical Trials Data Monitoring Committees; Clinical trial protocol document; Community Clinical Oncology Program; Comprehensive Cancer Center; County; Data; Data Analyses; Direct Costs; Doctor of Philosophy; Education; Educational workshop; Ensure; Epidemiology; Evaluation; Faculty; Funding; Goals; Health Sciences; Hospitals; Informatics; Institution; International; Journals; Los Angeles; Malignant Neoplasms; Manuscripts; Medical; Medicine; Methodology; Mission; Monitor; NCI Center for Cancer Research; Oncology; Peer Review; Population; Population Study; Preparation; Protocols documentation; Publications; Reporting; Research; Research Design; Research Personnel; Research Project Grants; Research Training; Resource Sharing; Resources; Review Committee; Role; Services; Site; Statistical Data Interpretation; Statistical Study; TimeLine; Training; Translational Research; Woman; anticancer research; biomathematics; cancer clinical trial; clinical practice; clinical trial analysis; clinical trial implementation; data acquisition; data management; design; gang; graduate student; high dimensionality; meetings; member; next generation; novel; professor; programs; protocol development; response; statistics

BIOSTATISTICS, ANALYTICAL SUPPORT AND EVALUATION SHARED RESOURCE (BASE) ABSTRACT The Biostatistics, Analytical Support & Evaluation Shared Resource (BASE) goal is to provide comprehensive and high quality biostatistics support for basic and translational cancer-related research, clinical trials and population studies in the UCLA Jonsson Comprehensive Cancer Center (JCCC). The BASE Shared Resource promotes excellence in cancer research by engagement in a study from its inception to its conclusion, through statistical support on study design, data analysis, interpretation of study results, and manuscript preparation. BASE services for JCCC members also includes statistical study design prior to a grant application, with BASE statisticians supported as co-investigators when funding occurs. BASE supports two critical JCCC standing committees: the Internal Scientific Protocol Review Committee (ISPRC), by providing statistical review of clinical trials protocols, and the Data & Safety Monitoring Board (DSMB), by providing statistical support for the implementation, conduct, and monitoring of oncology clinical trials. In addition, the BASE Shared Resource collaborates closely with several campus informatics facilities to support data management for cancer studies. BASE faculty members also develop novel statistical methodologies in response to the needs of JCCC research projects to facilitate such studies. The JCCC BASE Shared Resource was established in 1994. Gang Li, PhD (ZY), an international leader in biostatistics, has been the BASE Director since 2007, and David Elashoff, PhD (ZY) serves as Co-Director. BASE includes five additional faculty members and a staff biostatistician from the UCLA Departments of Biostatistics, Biomathematics, and Medicine. These faculty members are nationally respected biostatisticians with broad expertise in general biostatistics, the design and analysis of clinical trials, bioinformatics, and the analysis and interpretation of high-dimensional high throughput data. During the previous six-year period, the BASE Shared Resource supported projects from 55 JCCC members originating in all six JCCC Research Programs, representing 85% of overall Shared Resource usage. Of this, 64% supported members with peer- review funded research and 21% members without peer-review funded research, resulting in 320 publications, 36% of which were in high-impact (IF ≥10, or field leading) journals. The BASE Shared Resource assisted in a large number of cancer grant applications, with 31 successfully awarded for ~$64M in total direct cost funding. In addition, the BASE Shared Resource supported 39 cancer clinical trials during the past six-year project period. The role of the BASE Shared Resource in the facilitation of study design, data analysis, grant applications, protocol review, design, and implementation of clinical trials and data management is central to the mission of the UCLA JCCC.

生物统计学，分析支持和评估共享资源（基础） 抽象的 生物统计学，分析支持和评估共享资源（基本）目标是提供全面 以及高质量的生物统计学支持基础和翻译的癌症相关研究，临床试验和 加州大学洛杉矶分校琼斯综合癌症中心（JCCC）的人口研究。基本共享资源 通过参与从成立到结论的研究来促进癌症研究的卓越，通过 研究设计，数据分析，研究结果的解释和手稿准备的统计支持。 JCCC成员的基础服务还包括授予申请之前的统计研究设计 当资金发生时，统计学家支持共同研究。基础支持两个关键的JCCC站立 委员会：内部科学协议审查委员会（ISPRC），通过提供临床统计审查 试验协议以及数据与安全监控委员会（DSMB），通过为 实施，进行和监测肿瘤学临床试验。此外，基本共享资源 与几个校园信息设施密切合作，以支持癌症研究的数据管理。 基础教师还开发了针对JCCC研究需求的新型统计方法 促进此类研究的项目。 JCCC基础共享资源成立于1994年。GangLi，Phd（ZY），国际领导人 Biostatistics自2007年以来一直是基础主任，David Elashoff博士（ZY）担任联合导演。 基地包括另外五名教职员工和一名来自UCLA部门的员工生物统计学家 生物统计学，生物学和医学。这些教职员工是全国受人尊敬的生物统计学家 具有一般生物统计学的广泛专业知识，临床试验，生物信息学和分析的设计和分析 高维高吞吐量数据的分析和解释。在前六年中， 基本共享资源支持的项目来自55名JCCC成员，这些项目源自所有六项JCCC研究 计划，占总共享资源使用情况的85％。其中，有64％的人支持同伴的成员 审查资助的研究和21％的成员没有同行评审资助的研究，从而有320个出版物， 其中36％是在高影响力（如果≥10或田间引导）期刊中。基本共享资源有助于 大量的癌症赠款申请，成功授予31万美元的直接成本资金约6400万美元。 此外，在过去六年的项目期间，基本资源共享资源支持39次癌症临床试验。 基本共享资源在促进研究设计，数据分析，赠款应用程序中的作用， 协议审查，设计和实施临床试验和数据管理是使命的核心 UCLA JCCC。