A Cognitive-Behavioral Intervention for Children with Autism Spectrum Disorders

针对自闭症谱系障碍儿童的认知行为干预

• 批准号: 7690217
• 负责人: Susan Williams White
• 金额: $ 13.47万
• 依托单位: VIRGINIA POLYTECHNIC INST AND ST UNIV
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7690217
• 关键词: Address; Adherence; Adolescent; Advanced Development; Amendment; Anxiety; Applications Grants; Area; Award; Child; Clinical; Clinical Trials; Complement; Consultations; Data; Data Analyses; Development; Development Plans; Disease; Educational Curriculum; Environment; Ethics; Evaluation; Evidence based treatment; Feasibility Studies; Foundations; Funding; Goals; Growth; Impairment; Instruction; Intervention; Intervention Studies; Investigation; Knowledge; Learning; Mainstreaming; Manuals; Measures; Mentored Research Scientist Development Award; Mentors; Methodology; Modeling; Phase; Pilot Projects; Population Heterogeneity; Positioning Attribute; Principal Investigator; Randomized Controlled Trials; Research; Research Activity; Research Design; Research Project Grants; Research Proposals; Research Training; Sampling; School-Age Population; Scientist; Social Interaction; Social skills development; Staging; Statistical Methods; Structure; Symptoms; Techniques; Testing; Training; Translating; Translations; Treatment outcome; autism spectrum disorder; base; career; career development; childhood anxiety; cognitive behavior therapy; design; disability; effectiveness research; effectiveness trial; efficacy testing; evidence base; experience; novel; peer; prevent; psychosocial; social; social skills; treatment program

DESCRIPTION (provided by candidate): I am applying for the Mentored Research Scientist Development Award (K01) program to promote my growth as an independent scientist. My goal with this award is to obtain the advanced training I need to develop an evidence-based treatment manual for a social skills intervention for children with autism spectrum disorders (ASD), and subsequently apply for an R01 to test these interventions in clinical trials. Children and adolescents with ASD who are cognitively 'high-functioning' frequently present with symptoms of anxiety, in addition to the core impairment in social interaction. This anxiety can interfere with their ability to integrate into mainstream academic environments, undermine their use of appropriate social skills in natural peer contexts, and impede their overall development. Thus, anxiety can be seen as compounding the social disability inherent in spectrum disorders, preventing otherwise able children from reaping the maximum benefit from interventions targeting social skill development. The K01 career development aims will allow me to gain additional instruction, mentoring and experience in: (1) assessment and treatment of ASD and childhood anxiety; (2) the design of psychosocial treatment manuals; (3) methods and statistical techniques appropriate for the design and conduct of randomized controlled trials of psychosocial interventions; and (4) responsible and ethical conduct of research. These training objectives relate directly to my research plan, the ultimate goal of which is to develop an evidence-based, efficacious treatment program for children with ASD that targets social skill development and anxiety reduction. The aims of this research are: (1) to develop an alpha version of a treatment manual that addresses social skill development and co-occurring anxiety in school-age children and adolescents with ASD; (2) to pilot strategies comprising the treatment manual with a small group (n=5) of children to refine intervention strategies and delivery; (3) to collect preliminary data on the short-term efficacy, as well as feasibility, of this structured manual-based treatment in a sample (n=24) of children with ASD complicated by anxiety; and (4) to develop a grant application to conduct a larger scale efficacy study of the treatment curriculum. Through this training and research plan, I will be well-positioned to carry out independent investigations designed to translate an empirical understanding of anxiety and social disability in children with high-functioning ASD into novel treatment approaches.

描述（由候选人提供）：我正在申请指导的研究科学家发展奖（K01）计划，以促进我作为独立科学家的成长。我的奖项的目标是获得高级培训，我需要为自闭症谱系障碍儿童（ASD）的社交技能干预制定基于证据的治疗手册，并随后申请R01在临床试验中测试这些干预措施。除了社交互动的核心损害外，经常出现焦虑症状的ASD的儿童和青少年经常出现认知“高功能”的儿童和青少年。这种焦虑会干扰他们融入主流学术环境的能力，破坏他们在自然的同伴环境中使用适当的社交技能的能力，并阻碍其整体发展。因此，焦虑可以看作是使频谱障碍固有的社会残疾更加复杂，以防止否则能够从针对社会技能发展的干预措施中获得最大收益。 K01职业发展的目标将使我能够获得更多的指导，指导和经验：（1）评估和治疗ASD和儿童焦虑； （2）心理社会治疗手册的设计； （3）适用于设计和执行社会心理干预措施的随机对照试验的方法和统计技术； （4）研究的负责和道德行为。这些培训目标直接与我的研究计划有关，最终目标是针对ASD儿童制定基于证据的，有效的治疗计划，该治疗计划针对社交技能发展和减轻焦虑。这项研究的目的是：（1）开发一种治疗手册的α版本，该手册涉及与ASD的学龄儿童和青少年的社会技能发展和同时发生的焦虑； （2）针对包括一小组儿童（n = 5）的治疗手册的试点策略，以完善干预策略和分娩； （3）收集有关这种基于手动手动的治疗的短期疗效以及可行性的初步数据（n = 24），患有焦虑症的ASD儿童（n = 24）； （4）开发赠款应用，以对治疗课程进行更大的规模疗效研究。通过这个培训和研究计划，我将有充分的态度进行独立的研究，旨在将高功能ASD的儿童的焦虑和社会残疾的经验理解转化为新型治疗方法。