Biostatistics, Analytic Support and Evaluation Shared Resource

生物统计学、分析支持和评估共享资源

• 批准号: 7944588
• 负责人: GANG LI
• 金额: $ 56.66万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-02 至 2013-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7944588
• 关键词: Adherence; Adverse event; Amendment; Area; Biometry; Brain Neoplasms; Cancer Center; Cancer Center Support Grant; Characteristics; Clinical Trials; Clinical Trials Data Monitoring Committees; Clinical Trials Design; Collaborations; Computer software; Computers; Data; Data Analyses; Development; Development Plans; Drops; Drug Kinetics; Education; Equipment; Evaluation; Faculty; Funding; Gene Expression; Goals; Image; Jonsson Comprehensive Cancer Center of University of California Los Angeles; Manuscripts; Measures; Methodology; Modification; Monitor; Peer Review; Preparation; Protocols documentation; Recording of previous events; Reporting; Research; Research Design; Research Personnel; Resource Sharing; Review Committee; Sample Size; Services; Specific qualifier value; Statistical Models; Surveys; Tissue Microarray; Work; base; career; computerized; data acquisition; data management; informatics shared resource; medical specialties; member; oncology; programs; research study

The goals of the Biostatistics. Analytic Support and Evaluation (BASE) Shared Resource are to provide high-quality service and collaboration with Cancer Center members who require biostatistical assistance in these study components: Design of studies, including data management aspects of studies Monitoring of the implementation of studies, including adherence to the approved protocol, review of protocol amendments, data acquisition issues and accrual Development of data analysis protocols, including statistical modeling of data in designed studies, assessment of the initial data analysis plan, and necessary modifications of the plan Responsibility, when agreed upon with Cancer Center members, to carry out planned and alternative data analyses including, where appropriate, guidance for detailed conduct of the analyses Preparation of manuscripts, especially biostatistical results, methodology and interpretation of the data analysis results Availability of necessary computer equipment and software for computerized data analysis and management, which the BASE Unit maintains for general biostatistical methodology and supporting specialty areas such as pharmacokinetics, tissue array, microarray gene expression, clinical trials, imaging (especially for brain tumors), and repeated measures. Please also see Section 6.2.3 on Shared Resources in the History, Description, Essential Characteristics. 45 Cancer Center members representing 11 Cancer Center Program Areas utilized the services of the BASE Shared Resource during the reporting period. This is a continuing shared resource.

生物统计学的目标。分析支持和评估 (BASE) 共享资源将提供 与需要生物统计帮助的癌症中心成员提供高质量的服务和合作 这些研究组成部分： 研究设计，包括研究的数据管理方面 监测研究的实施，包括遵守批准的方案、审查 协议修订、数据采集问题和应计费用 数据分析协议的开发，包括设计研究中数据的统计建模， 评估初始数据分析计划，并对计划进行必要的修改 与癌症中心成员商定后，有责任执行计划的和替代的 数据分析，酌情包括详细进行分析的指导 准备手稿，特别是生物统计结果、方法和数据解释 分析结果 拥有必要的计算机设备和软件，用于计算机数据分析和 管理，由 BASE 部门维护，用于一般生物统计方法和支持 专业领域，如药代动力学、组织阵列、微阵列基因表达、临床试验、 成像（尤其是脑肿瘤）和重复测量。 另请参阅第 6.2.3 节“历史记录、描述、基本特征”中的共享资源。 代表 11 个癌症中心计划领域的 45 名癌症中心成员使用了 报告期内的 BASE 共享资源。这是一个持续的共享资源。