Neuroimaging Core (NI)

神经影像核心 (NI)

• 批准号: 10381593
• 负责人: Truman R Brown
• 金额: $ 22.19万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-02 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10381593
• 关键词: Acute Brain Injuries; Address; Anatomy; Animal Model; Animals; Attenuated; Basal metabolic rate; Behavior assessment; Biological Markers; Biomedical Engineering; Brain; Centers of Research Excellence; Clinical Research; Collaborations; Complex; Computer software; Data; Data Analyses; Data Set; Databases; Development; Dose; Electroencephalography; Evaluation; Functional Imaging; Functional Magnetic Resonance Imaging; Funding; Future; Human; Human Resources; Image; International; Intervention; Libraries; Liquid substance; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measurement; Measures; Mentors; Metabolic; Metabolism; Methodology; Methods; Modernization; Motion; Muscle; Nature; Neuronal Plasticity; Pathology; Phase; Positioning Attribute; Recovery; Rehabilitation therapy; Reproducibility; Research; Research Design; Research Personnel; Resources; Rodent; SCTR gene; Scalp structure; Scanning; South Carolina; Specific qualifier value; Spectrum Analysis; Stroke; System; Techniques; Technology; Time; Tissues; Training; Transcranial magnetic stimulation; Translating; Translational Research; Translations; United States National Institutes of Health; Widespread Disease; acronyms; animal resource; arterial spin labeling; base; behavioral outcome; biomedical imaging; blood oxygen level dependent; brain magnetic resonance imaging; brain morphology; clinical database; cranium; data sharing; density; equipment training; exercise regimen; experience; faculty mentor; functional plasticity; gray matter; hemodynamics; human subject; imaging modality; individual patient; innovation; large datasets; method development; morphometry; multidisciplinary; multimodality; neuroimaging; neuroimaging marker; neuromechanism; neurophysiology; novel; open source tool; post stroke; rehabilitation research; relating to nervous system; repository; response; senior faculty; software development; stroke recovery; stroke rehabilitation; successful intervention; tool; two photon microscopy

The Neuroimaging Core (NI) provides access to state-of-the art neuroimaging facilities and methodologies. COBRE funds will support a Bioengineer (shared with the BSTIM Core) who will oversee the technical aspects and develop new methods to interface image acquisition with stimulation and rehabilitation techniques; a full- time Image Technician who will provide training and assistance for analysis and interpretation of complex measurements; partial effort of an EEG Technician who will provide guidance in techniques for high density EEG and assist with data analyses; and dedicated effort for senior faculty who will provide mentoring and training in rigor, reproducibility and interpretation as well as methods development for human and animal studies. Specific aims are to: (1) Provide COBRE investigators with turnkey access to modern neuroimaging tools to investigate stroke-recovery related changes in brain morphology, connectivity, metabolism and function; (2) Develop innovative tools to observe the detailed neural response (both short- and long-term) to diverse interventions; 3) Generate high quality, reproducible, quantitative data to help identify neuroimaging “biomarkers” and thereby become a leader in forming large multi-system quantitative data sets for inclusion in the COBRE Comprehensive Multidisciplinary Database (CMD) as well as national and international data sharing efforts; and 4) Mentor and train COBRE investigators in the acquisition and analysis of complex neuroimaging data so they can investigate and exploit inherent plasticity and develop and translate novel mechanism-based, experience-dependent interventional methods. Continuous progress toward these aims will establish the NI Core as a premier resource in the integration of neuroimaging into stroke rehabilitation studies at MUSC, as well as nationally and internationally. The NI Core will facilitate investigators’ access to structural and functional imaging methods such as blood oxygen level dependent (BOLD) magnetic resonance spectroscopy (MRS), arterial spin labeling (ASL), and high density electroencephalography (EEG), enabling them to ask important research questions such as tissue volume associated with the stroke and adaptive plasticity, stroke pathology, correlates of basal metabolism, local estimates of cellular complexity, regional responses to localized brain stimulation and corresponding functional responses. The NI Core’s multimodal, cross-disciplinary, integrative nature encourages collaborative innovation. The ability to use transcranial magnetic stimulation within the scanner (i.e., interleaved TMS/fMRI) makes MUSC one of very few places where investigators can directly examine immediate and longer- term effects of brain stimulation interventions on brain activity and hemodynamics, and investigate the causal nature of induced activity in cortical and subcortical nodes of a brain network. In addition, 7T small animal scanning and two-photon microscopy systems provide sensitive translational tools to investigate mechanisms underlying rehabilitation and cortical stimulation enhancement of neural plasticity and stroke recovery in animal models.

神经成像核心（NI）提供了对最先进的神经影像学设施和方法的访问。 COBRE资金将支持将监督技术方面的生物工程师（与BSTIM核心共享） 并开发新方法将图像获取与刺激和康复技术相连；一个完整的 时间图像技术人员将提供培训和协助以分析和解释复杂 测量；脑电图技术人员的部分努力，将为高密度脑电图提供指导 并协助数据分析；以及将为高级教师提供精神和培训的奉献精力 严格，可重复性和解释以及人类和动物研究的方法发展。具体的 目的是：（1）为毛to研究者提供交钥匙访问现代神经影像学工具的访问 脑形态，连通性，代谢和功能的相关变化； （2）发展 创新的工具，以观察对潜水干预措施的详细中性反应（短期和长期）； 3） 产生高质量，可重现的定量数据，以帮助识别神经影像学的“生物标志物”，从而有助于 成为形成大型多系统定量数据集的领导者 多学科数据库（CMD）以及国家和国际数据共享工作； 4）导师和 训练COBRE研究者在获取和分析复杂神经影像数据中，以便他们可以调查 并探索固有的可塑性，并发展和翻译基于经验的新机制 介入方法。朝着这些目标的持续进展将建立NI核心作为主要资源 在MUSC以及全国以及全国和 国际。 NI核心将促进研究人员的结构和功能成像方法的访问 作为血氧水平依赖（粗体）磁共振光谱（MRS），动脉自旋标记（ASL）， 和高密度脑电图（EEG），使他们能够提出重要的研究问题，例如 与中风和自适应可塑性，中风病理学，基本相关性相关的组织体积 代谢，细胞复杂性的局部估计，对局部脑刺激的区域反应和 相应的功能响应。 NI Core的多模式，跨学科的综合性质鼓励 协作创新。在扫描仪内使用经颅磁刺激的能力（即交错 TMS/fMRI）使MUSC成为很少有研究人员可以直接检查并更长地检查的地方之一 脑刺激干预措施对脑活动和血液动力学的术语影响，并研究因果关系 脑网络皮质和皮质下淋巴结中诱导活性的性质。另外，7t小动物 扫描和两光子显微镜系统提供了敏感的翻译工具来研究机制 动物中神经可塑性和中风恢复的潜在康复和皮质刺激增强 型号。