Functional Microbiomics, Inflammation and Pathogenicity

功能微生物组学、炎症和致病性

• 批准号: 10349566
• 负责人: Richard J Lamont
• 金额: $ 213.57万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-03-01 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10349566
• 关键词: Anaerobic Bacteria; Anti-Inflammatory Agents; Area; Autoimmune Diseases; Basic Science; Bioinformatics; Biological Assay; Biometry; Centers of Research Excellence; Chronic; Colorectal Cancer; Communities; Complex; Dentistry; Development; Disease; Distant; Education; Engineering; Ensure; Environment; Environmental Science; Equilibrium; Evaluation; Extramural Activities; Faculty; Funding; Germ-Free; Goals; Health; Health Sciences; Homeostasis; Human; Human Microbiome; Immune response; Immune system; Immunologist; Immunology; Indigenous; Inflammation; Inflammatory; Inflammatory Bowel Diseases; Inflammatory Response; Infrastructure; Interdisciplinary Study; International; Lead; Location; Mentors; Methods; Microbe; Microbiology; Monitor; Mucous Membrane; Natural Immunity; Normal tissue morphology; Outcomes Research; Parkinson Disease; Pathogenicity; Pathology; Pathway interactions; Periodontitis; Physiology; Pilot Projects; Play; Positioning Attribute; Postdoctoral Fellow; Process; Recovery; Renaissance; Research; Research Infrastructure; Research Personnel; Research Priority; Research Project Grants; Resources; Rheumatoid Arthritis; Role; Scientist; Services; Shapes; Site; Specificity; Structure; Surface; System; Talents; Teacher Professional Development; Therapeutic Agents; Time; Tissues; Training; Universities; animal facility; autism spectrum disorder; bioimaging; career development; chronic infection; dysbiosis; graduate student; host-microbe interactions; immune system function; inflammatory marker; intercellular communication; medical schools; microbial; microbial community; microbiome; microbiome research; microbiome sequencing; microbiota; multidisciplinary; nervous system disorder; novel; novel therapeutics; pathogen; programs; recruit; response; tool

In the past few decades, the fields of microbiology and immunology have undergone a renaissance, driven in part by technological advances which have shaped our understanding of microbes as components of complex, polymicrobial, interactive communities. This microbiome can play a role in a number of fundamental aspects of human health and disease, in many instances through the interface with host innate immunity. The immune system functions to restrict the potential for damage caused by the microbiota while simultaneously minimizing destructive inflammatory responses. Disruption of the intensity, duration or physical location of inflammation, however, can contribute to disease. Advances in our understanding of the microbiome, along with a realization that inflammatory processes are at the core of a number of common diseases, necessitates a cross-disciplinary perspective that accommodates the host-microbe interaction in toto. The major goal of this COBRE is to establish a thematic multidisciplinary research center for the study of the interface between the microbiome, inflammation and pathogenicity. We have assembled a team of junior investigators with complementary expertise and outstanding potential, and have partnered these project leaders with well-qualified and dedicated mentors. An integrated set of complementary projects will make novel connections between inflammatory processes and bacterial pathogenicity, and establish the basis for the development of novel therapeutics and delivery methods. We will create a multidisciplinary program in research, education, mentoring and career development that will facilitate and accelerate the transition of junior faculty to independent extramural funded status. Research will be support by a Functional Microbiomics Core that will provide germ free animal facilities, anaerobic culture capability, microbiome sequencing and bioinformatics, assay of inflammatory markers, and pathology services. An Administrative Core will co-ordinate activities and provide additional biostatistical and bioimaging support, along with a Pilot Project program to ensure a pipeline of investigators. Institutional commitment will also help ensure long term sustainability of the thematic research program.

在过去的几十年里，微生物学和免疫学领域经历了复兴， 部分原因是技术进步塑造了我们对微生物作为复杂物质组成部分的理解， 多微生物、互动群落。该微生物组可以在许多基本方面发挥作用 人类健康和疾病，在许多情况下是通过与宿主先天免疫的相互作用来实现的。免疫 系统的功能是限制微生物群造成的潜在损害，同时最大限度地减少 破坏性的炎症反应。破坏炎症的强度、持续时间或物理位置， 然而，可能会导致疾病。我们对微生物组理解的进步以及认识 炎症过程是许多常见疾病的核心，需要跨学科的研究 整体上容纳宿主-微生物相互作用的观点。 COBRE 的主要目标是 建立一个专题多学科研究中心，研究微生物组之间的界面， 炎症和致病性。我们组建了一支由初级研究人员组成的团队，他们具有互补性 专业知识和杰出的潜力，并与这些项目领导者合作，他们具有高素质和敬业精神 导师。一套完整的互补项目将在炎症之间建立新的联系 过程和细菌致病性，并为开发新的治疗方法和建立基础 交付方式。我们将创建一个涵盖研究、教育、指导和职业的多学科项目 的发展将促进和加速初级教师向独立的校外资助的过渡 地位。研究将得到功能微生物组学核心的支持，该核心将提供无菌动物设施， 厌氧培养能力、微生物组测序和生物信息学、炎症标记物测定，以及 病理学服务。行政核心将协调活动并提供额外的生物统计和 生物成像支持以及试点项目计划，以确保研究人员的渠道。制度性 承诺还将有助于确保专题研究计划的长期可持续性。