Functional Microbiomics, Inflammation and Pathogenicity

功能微生物组学、炎症和致病性

• 批准号: 10492096
• 负责人: Richard J Lamont
• 金额: $ 234.75万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-03-01 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10492096
• 关键词: Acceleration; Autoimmune Diseases; Basic Science; Bioinformatics; Biological Assay; Biometry; Career Mobility; Centers of Research Excellence; Chronic; Communities; Complex; Dedications; Development; Disease; Ensure; Environment; Environmental Risk Factor; Evaluation; Extramural Activities; Faculty; Funding; Germ-Free; Goals; Health; Health Transition; Homeostasis; Human; Human Microbiome; Human body; Immune response; Immune system; Immunologics; Immunology; Infection; Inflammation; Inflammatory; Inflammatory Response; Infrastructure; Institution; Interdisciplinary Study; International; Location; Mentors; Methods; Microbiology; Mucous Membrane; Natural Immunity; Outcomes Research; Pathogenicity; Pathway interactions; Phase; Pilot Projects; Postdoctoral Fellow; Process; Qualifying; Regulation; Renaissance; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resources; Scientist; Site; Specificity; Structure; System; Talents; Technology; Therapeutic Agents; Tissues; Training; Universities; animal facility; career; career development; design; experience; graduate student; host-microbe interactions; imaging capabilities; immune system function; inflammatory marker; innovation; interdisciplinary approach; intravital microscopy; microbial; microbial community; microbiome; microbiome research; microbiome sequencing; microbiota; multidisciplinary; novel; novel therapeutics; pathogen; programs; recruit; research and development; response; senior faculty; success; synergism; whole animal imaging

Project Summary/Abstract In the past few decades, the fields of microbiology and immunology have undergone a renaissance, driven in part by technological advances establishing that the human microbiome can play a role in a number of fundamental aspects of human health and disease, in many instances through the interface with host innate immunity. The immune system functions to restrict the potential for damage caused by the microbiota while simultaneously minimizing destructive inflammatory responses. Disruption of the intensity, duration or physical location of inflammation, however, can contribute to disease. Advances in our understanding of the microbiome, and its regulation by environmental factors, along with a realization that inflammatory processes are at the core of a number of common diseases, necessitates a cross-disciplinary perspective that accommodates the host- microbe interaction in toto. The major goal of this Phase 2 Cobre is to continue to develop and expand our thematic multidisciplinary research center for the study of the interface between the microbiome, inflammation and pathogenicity within a framework to develop the careers of junior investigators. We have assembled a team of junior investigators with complementary expertise and outstanding potential, and have partnered these project leaders with well-qualified and dedicated mentors. An integrated set of projects will make novel connections between inflammatory processes and bacterial pathogenicity, and establish the basis for the development of novel therapeutics and delivery methods. We will create a multidisciplinary program in research, training, mentoring and career development that will facilitate and accelerate the transition of junior faculty to independent extramural funded status. Research will be support by a Functional Microbiomics Core that will provide germ free animal facilities, anaerobic culture capability, microbiome sequencing and bioinformatics, assay of inflammatory markers, along with whole animal imaging and intravital microscopy. An Administrative Core will co-ordinate activities and provide additional biostatistical support, along with a Pilot Project program to ensure a pipeline of investigators. Institutional commitment through a university funded Center will ensure sustainability of the thematic research program.

项目概要/摘要 在过去的几十年里，微生物学和免疫学领域经历了复兴， 部分原因是技术进步证明人类微生物组可以在许多方面发挥作用 人类健康和疾病的基本方面，在许多情况下是通过与宿主先天的接口 免疫。免疫系统的功能是限制微生物群造成的潜在损害，同时 同时最大限度地减少破坏性炎症反应。强度、持续时间或体力的破坏 然而，炎症的部位可能会导致疾病。我们对微生物组的理解取得了进展， 及其受环境因素的调节，以及炎症过程是核心的认识 一些常见疾病的研究需要跨学科的视角，以适应宿主的需要 微生物相互作用。 Cobre 第二阶段的主要目标是继续发展和扩大我们的 专题多学科研究中心，研究微生物组、炎症之间的相互作用 和致病性在一个框架内发展初级研究人员的职业生涯。我们已经组建了一个团队 具有互补专业知识和突出潜力的初级研究人员，并与这些项目合作 拥有高素质且敬业的导师的领导者。一系列综合项目将建立新颖的联系 炎症过程和细菌致病性之间的关系，并为炎症过程的发展奠定基础 新的治疗方法和递送方法。我们将在研究、培训、 指导和职业发展，将促进和加速初级教师向独立教师的过渡 外部资助地位。研究将得到功能微生物组学核心的支持，该核心将提供细菌 免费动物设施、厌氧培养能力、微生物组测序和生物信息学、检测 炎症标记物，以及整个动物成像和活体显微镜检查。行政核心将 协调活动并提供额外的生物统计支持以及试点项目计划，以确保 调查人员的管道。通过大学资助的中心的机构承诺将确保可持续性 的专题研究计划。