COBRE-Administrative Core

COBRE-管理核心

• 批准号: 10349567
• 负责人: Richard J Lamont
• 金额: $ 108.6万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-03-01 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10349567
• 关键词: Acute; Address; Applications Grants; Area; Biological Warfare; Biomedical Engineering; Biometry; Bubonic Plague; Budgets; Burkholderia pseudomallei; Centers of Research Excellence; Communicable Diseases; Conflict (Psychology); Country; Disease; Disease Outcome; Ensure; Faculty; Funding; Germ-Free; Goals; Guidelines; Health; Human; Human Microbiome; Immunology; Incidence; Individual; Inflammation; Inflammatory; Inflammatory Response; Interdisciplinary Study; International; Location; Melioidosis; Mentors; Microbiology; Modality; Natural Immunity; Pathogenicity; Plague; Play; Population; Process; Records; Regulation; Research; Research Personnel; Role; Structure; Universities; Work; Yersinia pestis; animal facility; bioimaging; chronic inflammatory disease; cohesion; graduate student; host-microbe interactions; immune system function; microbiome; microbiome research; microbiota; minority communities; multidisciplinary; nature center; new technology; new therapeutic target; oral immunology; oral infection; pathogen; recruit; student training; underserved community

The University of Louisville (UofL) COBRE in Functional Microbiomics, Inflammation and Pathogenicity comprises a multidisciplinary group of investigators addressing thematic aspects of microbiome, inflammation and pathogenicity studies. The UofL is uniquely poised to investigate these problems in a coordinated and efficient fashion, and the COBRE is horizontally integrated with a number of UofL funded initiatives and grant applications in related areas. The departments of Oral Immunology and Infectious Diseases, Microbiology and Immunology, and Bioengineering all contribute to the cross-disciplinary nature of the center. These units have established records of federal funding, mentoring junior faculty, graduate student training, and collaborative interactions across campus. This application is led by well-qualified and well-funded Center Directors. There are five outstanding PI-mentees with senior, established, funded mentoring teams. Our proposed COBRE will have a major positive impact on research throughout UofL, and will help recruit and retain faculty. The germ free animal facility to be established will be one of only a few in the country. Many of the projects address chronic inflammatory diseases that occur at disproportionately high incidence in minority communities. Other projects involving plague and melioidosis have national and international significance. The Administrative Core will provide overall governance and will ensure that the COBRE projects and cores work together in a cohesive and coordinated manner. All projects and cores will utilize the Administrative Core. The Specific Aims are: to provide a formal governance structure to allow coordination, direction and prioritization of activities, including budget issues, ensuring the quality of all functions; to evaluate progress; to resolve any conflicts as they arise; to provide a formalized process for mentoring junior faculty; to provide a mechanism to replace mentees as they become independent; to provide a mechanism to replace any key individuals who may leave; to provide pilot funding for junior faculty to ensure a pipeline of investigators; to provide biostatistical and bioimaging support; and to disseminate pertinent information resulting from the COBRE activities.

路易斯维尔大学 (UofL) COBRE 功能微生物组学、炎症和致病性 由多学科研究人员组成，研究微生物组、炎症等主题方面 和致病性研究。伦敦大学专门准备以协调一致的方式调查这些问题 高效的时尚，COBRE 与伦敦大学资助的许多举措和赠款横向整合 相关领域的应用。口腔免疫学和传染病学系、微生物学系和 免疫学和生物工程都有助于该中心的跨学科性质。这些单位有 建立联邦资助、初级教师指导、研究生培训和协作记录 校园内的互动。该申请由合格且资金充足的中心主任领导。有 五位杰出的 PI 学员，拥有资深、成熟、受资助的指导团队。我们提议的 COBRE 将具有 对整个伦敦大学的研究产生重大积极影响，并将有助于招聘和留住教师。无菌的 即将建立的动物设施将是该国仅有的几个动物设施之一。许多项目针对慢性病 少数族裔社区发病率极高的炎症性疾病。其他项目 涉及鼠疫和类鼻疽具有国家和国际意义。行政核心将 提供全面治理，并将确保 COBRE 项目和核心以有凝聚力和 协调一致的方式。所有项目和核心都将利用管理核心。具体目标是：提供 正式的治理结构，以协调、指导和确定活动的优先顺序，包括预算 问题，确保所有功能的质量；评估进展；解决出现的任何冲突；提供 指导初级教师的正式流程；提供一种机制来替换受训者 独立的;提供一种机制来替换任何可能离开的关键人员；提供试点资金 初级教师，以确保研究人员的渠道；提供生物统计和生物成像支持；并到 传播 COBRE 活动产生的相关信息。