Boston Alcohol Research Collaboration on HIV/AIDS - Comorbidity Center (Boston ARCH CC)

波士顿酒精艾滋病毒/艾滋病研究合作 - 合并症中心 (Boston ARCH CC)

• 批准号: 10304666
• 负责人: Michael D Stein
• 金额: $ 149.41万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-22 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10304666
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Affect; Alcohol consumption; Alcohol or Other Drugs use; Alcohols; Behavioral; Biometry; Boston; Cardiovascular Diseases; Caring; Clinical Trials; Collaborations; Communities; Complex; Data; Data Analyses; Drug Use Disorder; Ecological momentary assessment; Ecology; Elderly; Enrollment; Funding; Goals; Grant; HIV; HIV Infections; Health; Health behavior; Heavy Drinking; Home; Infection; Infrastructure; Interdisciplinary Study; Intervention; Investigation; Lead; Life; Life Style; Longevity; Measurement; Mediator of activation protein; Medical; Medicine; Mentors; Methodology; National Institute on Alcohol Abuse and Alcoholism; Osteopenia; Outcome; Pain; Pain Research; Participant; Patients; Persons; Pharmaceutical Preparations; Physical Function; Physical activity; Play; Population; Procedures; Psychology; Public Health; Randomized Controlled Trials; Research; Research Methodology; Research Personnel; Research Project Grants; Risk; Risk Management; Role; Services; Sum; Testing; Translating; United States National Institutes of Health; Visit; Work; addiction; alcohol and other drug; alcohol misuse; alcohol research; alcohol use disorder; antiretroviral therapy; base; chronic pain; chronic painful condition; cohesion; cohort; community setting; comorbidity; data management; drinking; eHealth; efficacy testing; exercise intervention; falls; frailty; functional status; improved; interdisciplinary approach; interest; mental function; multidisciplinary; pandemic disease; physical inactivity; population based; programs; prospective; randomized trial; recruit; secondary analysis; secondary outcome; substance use; trial design

PROJECT SUMMARY/ABSTRACT Effective antiretroviral therapy has increased the lifespan of people living with HIV (PLWH). Alcohol use, common among PLWH, plays an increasingly important role in the risk for and management of HIV-associated comorbidities. Unhealthy drinking can exacerbate two highly prevalent HIV-related comorbidities/co-occurring conditions, chronic pain and physical inactivity, which in turn, can intensify alcohol use and affect physical and mental function in PLWH. We propose the Boston Alcohol Research Collaboration on HIV/AIDS – Comorbidity Center (Boston ARCH CC) as an extension of our Boston Alcohol Research Collaboration on HIV/AIDS (ARCH) cohort launched in 2011 and renewed in 2016 with funding from NIAAA. In Boston ARCH CC we target in randomized trials these two modifiable conditions, pain and physical inactivity, that have a critical impact on a variety of other HIV-related comorbidities. Boston ARCH CC contains 4 integrated components that make unique contributions to our interdisciplinary approach: two randomized trials (Research Project Components), an Administrative Core (AC) that coordinates the P01, and a Biostatistics and Data Management (BDM) Core that supports the trials methodologically and provides data management and biostatistical expertise to them, and continues secondary analyses using extant Boston ARCH data. In Objective 1 we will conduct state-of-the-art e-health clinical trials research on scalable approaches to address the HIV-associated conditions chronic pain and physical inactivity in PLWH with unhealthy alcohol use. By recruiting, assessing, and intervening with participants outside of standard medical visits, through entirely online e-health procedures, our trials address unhealthy drinking in the care of complex HIV patients. In Objective 2 we will support secondary analyses of the existing Boston ARCH cohort, and provide support and mentoring to trainees and investigators accessing the cohort data. The nearly ten- year prospective Boston ARCH cohort enrolled PLWH with current or past substance use, and provides the basis for creating a program for early stage alcohol-HIV investigators interested in scientific questions related to pain, physical inactivity, and physical and mental functioning. To achieve the goal of addressing these two co-occurring conditions, we bring together multidisciplinary experts in fields including alcohol and HIV, public health, addiction medicine, clinical trials, psychology, pain, physical activity, ecological momentary assessment, functional status measurement, and research methods and services (biostatistics and data management). The integration across these fields provides a cohesive program where the whole is bigger than the sum of the parts, supporting investigators whose work can be rapidly translated to community-based population impact.

项目摘要/摘要 有效的抗逆转录病毒疗法提高了艾滋病毒（PLWH）患者的寿命。饮酒， 在PLWH中常见，在与HIV相关的风险和管理中起着越来越重要的作用 合并症。不健康的饮酒会加剧两种非常普遍的HIV相关合并症/同时发生的合并症 疾病，慢性疼痛和身体不活跃，这又会加强酒精的使用并影响身体和 PLWH中的心理功能。我们提出了波士顿酒精研究在HIV/AIDS上的合作 - 合并症中心（波士顿Arch CC）作为我们波士顿酒精研究合作的延伸 艾滋病毒/艾滋病（ARC）队列于2011年启动，并于2016年通过NIAAA提供了资金。在波士顿拱门 CC我们在随机试验中靶向这两个可修改的疾病，疼痛和身体不活跃，具有 对其他与HIV相关的合并症的关键影响。波士顿Arch CC包含4个集成 为我们的跨学科方法做出独特贡献的组件：两个随机试验（研究 项目组件），一个协调P01的行政核心（AC），以及生物统计学和数据 管理（BDM）核心，该核心支持试验方法，并提供数据管理和 他们的生物统计学专业知识，并使用额外的波士顿拱门数据继续进行二次分析。在 目标1我们将对可扩展方法的最先进的电子健康临床试验研究 解决与艾滋病毒相关的疾病的慢性疼痛和不健康的PLWH的身体不活跃 饮酒。通过招募，评估和干预标准医疗访问以外的参与者， 通过完全在线电子健康程序，我们的试验解决了复杂艾滋病毒的不健康饮酒 患者。在目标2中，我们将支持现有波士顿拱门队列的次要分析，并支持 向访问队列数据的学员和调查人员提供支持和心理。近十个 年度前瞻性波士顿拱门队员招募了PLWH，并使用了当前或过去的物质使用，并提供了 为对与科学问题有关的早期酒精HIV调查人员创建计划的基础 疼痛，身体不活动以及身体和心理功能。实现解决这两个的目标 同时出现的条件，我们将酒精和艾滋病毒，公众在内的跨学科专家汇集在一起 健康，成瘾医学，临床试验，心理学，疼痛，体育锻炼，生态瞬间 评估，功能状态测量以及研究方法和服务（生物统计学和数据 管理）。这些领域之间的集成提供了一个具有凝聚力的程序，其中整体大于 零件的总和，支持调查人员，他们的工作可以迅速转化为基于社区的调查员 人口影响。