Yoga to Treat Chronic Pain in Persons Receiving Opioid Agonist Therapy
瑜伽可治疗接受阿片类激动剂治疗的患者的慢性疼痛
基本信息
- 批准号:9319211
- 负责人:
- 金额:$ 21.55万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-08-01 至 2019-05-31
- 项目状态:已结题
- 来源:
- 关键词:AdherenceAffectiveAgonistAlcohol or Other Drugs useAlcoholsAnxietyBehavioral MechanismsBenzodiazepinesBuprenorphineCognitiveCognitive TherapyComplementConfidence IntervalsControl GroupsDataEducationEducational InterventionEnrollmentFeedbackFocus GroupsFrightHealthHealth educationHyperalgesiaIllicit DrugsInterventionMaintenanceManualsMeditationMental DepressionNaloxoneOpiate AddictionOpioidOutcomePainPain managementParticipantPatientsPersonsPharmaceutical PreparationsPharmacological TreatmentPharmacologyPhasePhysical activityPopulationPostureProviderRandomized Clinical TrialsRelaxation TherapyReportingResearchSafetySeveritiesStudentsTrainingYogaaddictionattentional controlbasechronic paindisabilitydosageexperiencefollow-upillicit drug useimprovedinstructormethadone maintenancemindfulnessopiate toleranceopioid misuseopioid use disorderpatient populationpranayamapreventprimary outcomepublic health relevanceresearch and developmentsecondary outcomesubstance abusertherapy development
项目摘要
DESCRIPTION (provided by applicant): Chronic pain is a significant problem for people receiving opioid agonist therapy (OAT) for opioid dependence - i.e., buprenorphine/ naloxone (BUP) and methadone maintenance treatment (MMT). At least half of patients receiving BUP and MMT have chronic pain. Chronic pain is associated with pain-related disability, psychiatric problems, physical problems, and increased likelihood of misuse of opioids or other illicit drugs in this population, often leading providers to terminate treatment. Pharmacologic pain treatment in OAT patients is complicated by issues such as opioid-induced hyperalgesia, increased tolerance of opioids, other substance use, and patients' own fears about medications and addiction. Hatha yoga may be a beneficial adjunctive approach to treating chronic pain, decreasing pain-related disability, and preventing opioid misuse during OAT. Yoga includes benefits of relaxation training, physical activity, and mindfulness training in a unified practice.
Yoga is a promising approach for treating chronic pain in people enrolled in OAT because: 1) yoga has evidence supporting its ability to reduce pain-related disability and pain severity in other populations; 2) there are plausible cognitive/affective and behavioral mechanisms by which yoga may reduce chronic pain, decrease pain-related disability, and reduce opioid misuse; 3) yoga is increasingly available; and 4) yoga can complement other types of pain and substance use treatment. We propose to conduct treatment development research that would prepare us to study whether yoga (vs. a health education control group) might be an effective adjunctive treatment for pain in people enrolled in OAT for opioid use disorders. We hypothesize that, relative to a control group, yoga will: decrease pain-related disability (primary outcome), decrease pain, and decrease opioid misuse. This project will include two phases. In phase 1 (Treatment Development Stage 1A), we will use feedback from patient focus groups (n= 24 patients) and experts to refine our current hatha yoga intervention and health education intervention for specific use in people enrolled in OAT with chronic pain. In phase 2 (Treatment Development Stage 1B), we will conduct a pilot randomized clinical trial (n = 60) of yoga vs. health education groups (attention control) for persons with chronic pain who enrolled in OAT. Participants will be enrolled in the active intervention for 3 months, and then be followed for 6 months. Specifically, we will assess feasibility, acceptability, and safety of both the active intervention and control groups; assess differences between groups on outcomes (within relevant confidence intervals); examine changes on potential mechanisms of action, including mindfulness, pain catastrophizing, depression, and anxiety; and examine whether amount ("dosage") of yoga practice is related to key outcomes. This project will provide us with materials, experience, and pilot data necessary for the next stage of this line of research, namely, a fully powered randomized clinical trial. Hatha yoga has a potential to decrease pain-related disability, pain severity, and opioid misuse in this population of people with difficult-to
treat chronic pain.
描述(由申请人提供): 对于因阿片类药物依赖而接受阿片类药物激动剂治疗 (OAT)(即丁丙诺啡/纳洛酮 (BUP) 和美沙酮维持治疗 (MMT))的患者来说,慢性疼痛是一个严重的问题。 至少有一半的患者接受 BUP 和美沙酮维持治疗 (MMT)。 MMT 患有慢性疼痛,慢性疼痛与疼痛相关的残疾、精神问题、身体问题以及滥用阿片类药物或其他非法药物的可能性增加有关。由于阿片类药物引起的痛觉过敏、阿片类药物耐受性增加、其他物质使用以及患者自身对药物和哈他瑜伽的恐惧等问题,常常导致提供者终止对 OAT 患者的药物疼痛治疗。瑜伽期间治疗慢性疼痛、减少与疼痛相关的残疾和防止阿片类药物滥用的有益辅助方法包括统一练习中的放松训练、身体活动和正念训练。
瑜伽是治疗参加 OAT 的慢性疼痛的一种很有前途的方法,因为:1)有证据支持瑜伽能够减少其他人群中与疼痛相关的残疾和疼痛严重程度;2)有合理的认知/情感和行为机制可以帮助缓解疼痛。瑜伽可以减轻慢性疼痛,减少与疼痛相关的残疾,并减少阿片类药物的滥用;4)瑜伽可以补充其他类型的疼痛和药物使用治疗,为我们做好准备。研究瑜伽(与健康教育对于因阿片类药物使用障碍而参加 OAT 的患者来说,瑜伽可能是一种有效的疼痛辅助治疗方法,我们认为,相对于对照组,瑜伽将:减少与疼痛相关的残疾(主要结果)、减少疼痛和减少阿片类药物。该项目将包括两个阶段,在第一阶段(治疗开发阶段 1A),我们将利用患者焦点小组(n = 24 名患者)和专家的反馈来完善我们当前的哈他瑜伽干预和健康教育干预,以供具体使用。参加 OAT 的人在第 2 阶段(治疗开发阶段 1B),我们将对参加 OAT 的慢性疼痛患者进行瑜伽与健康教育组(注意力控制)的试点随机临床试验(n = 60)。参与主动干预 3 个月,然后随访 6 个月,具体而言,我们将评估主动干预组和对照组的可行性、可接受性和安全性;评估各组之间结果的差异(在相关置信区间内)。检查潜力的变化;行动机制,包括正念、疼痛灾难、抑郁和焦虑;并检查瑜伽练习的数量(“剂量”)是否与关键结果相关。该项目将为我们提供下一步所需的材料、经验和试点数据。该研究的一个阶段,即一项全面的随机临床试验,哈达瑜伽有可能减少这一难以治疗的人群中与疼痛相关的残疾、疼痛严重程度和阿片类药物的滥用。
治疗慢性疼痛。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Michael D Stein其他文献
Opioid Overdose Knowledge Among Adolescents and Young Adults.
青少年和年轻人的阿片类药物过量知识。
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:26.1
- 作者:
Christina E. Freibott;Noel Vest;Michael D Stein;S. Lipson - 通讯作者:
S. Lipson
Michael D Stein的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Michael D Stein', 18)}}的其他基金
Boston Alcohol Research Collaboration on HIV/AIDS - Comorbidity Center (Boston ARCH CC)
波士顿酒精艾滋病毒/艾滋病研究合作 - 合并症中心 (Boston ARCH CC)
- 批准号:
10304666 - 财政年份:2021
- 资助金额:
$ 21.55万 - 项目类别:
Optimization and multi-site feasibility of yoga for chronic pain in people in treatment for opioid use disorder
瑜伽治疗阿片类药物使用障碍患者慢性疼痛的优化和多部位可行性
- 批准号:
10356867 - 财政年份:2020
- 资助金额:
$ 21.55万 - 项目类别:
Optimization and multi-site feasibility of yoga for chronic pain in people in treatment for opioid use disorder
瑜伽治疗阿片类药物使用障碍患者慢性疼痛的优化和多部位可行性
- 批准号:
10512837 - 财政年份:2020
- 资助金额:
$ 21.55万 - 项目类别:
Optimization and multi-site feasibility of yoga for chronic pain in people in treatment for opioid use disorder
瑜伽治疗阿片类药物使用障碍患者慢性疼痛的优化和多部位可行性
- 批准号:
10451048 - 财政年份:2020
- 资助金额:
$ 21.55万 - 项目类别:
Optimization and multi-site feasibility of yoga for chronic pain in people in treatment for opioid use disorder
瑜伽治疗阿片类药物使用障碍患者慢性疼痛的优化和多部位可行性
- 批准号:
10586124 - 财政年份:2020
- 资助金额:
$ 21.55万 - 项目类别:
Treating Chronic Pain in Buprenorphine Patients in Primary Care Settings
在初级保健机构中治疗丁丙诺啡患者的慢性疼痛
- 批准号:
10343721 - 财政年份:2019
- 资助金额:
$ 21.55万 - 项目类别:
Treating Chronic Pain in Buprenorphine Patients in Primary Care Settings
在初级保健机构中治疗丁丙诺啡患者的慢性疼痛
- 批准号:
10561600 - 财政年份:2019
- 资助金额:
$ 21.55万 - 项目类别:
Improving Functioning in HIV Patients with Chronic Pain and Comorbid Depressive Symptoms
改善患有慢性疼痛和共存抑郁症状的艾滋病毒患者的功能
- 批准号:
9138424 - 财政年份:2016
- 资助金额:
$ 21.55万 - 项目类别:
Yoga to Treat Chronic Pain in Persons Receiving Opioid Agonist Therapy
瑜伽可治疗接受阿片类激动剂治疗的患者的慢性疼痛
- 批准号:
9091107 - 财政年份:2016
- 资助金额:
$ 21.55万 - 项目类别:
Improving Functioning in HIV Patients with Chronic Pain and Comorbid Depressive Symptoms
改善患有慢性疼痛和共存抑郁症状的艾滋病毒患者的功能
- 批准号:
9253445 - 财政年份:2016
- 资助金额:
$ 21.55万 - 项目类别:
相似国自然基金
基于个性化音乐的闭环情感脑机接口及其在意识障碍中的应用研究
- 批准号:82302339
- 批准年份:2023
- 资助金额:30 万元
- 项目类别:青年科学基金项目
tDCS缓解老年高孤独感的神经情感机制与个体化效应预测
- 批准号:82371558
- 批准年份:2023
- 资助金额:49 万元
- 项目类别:面上项目
地方感与虚拟地方感的关系研究:情感拓扑论的原理、机制与方法
- 批准号:42371234
- 批准年份:2023
- 资助金额:46 万元
- 项目类别:面上项目
教室课堂中基于多视觉分析的情感投入检测研究
- 批准号:62307009
- 批准年份:2023
- 资助金额:30 万元
- 项目类别:青年科学基金项目
CXCL10/CXCR3通路介导的神经炎症反应在狼疮脑病认知情感功能障碍中的作用机制研究
- 批准号:82301533
- 批准年份:2023
- 资助金额:30 万元
- 项目类别:青年科学基金项目
相似海外基金
Scrutinizing neuro-immune regulatory mechanisms underlying depressive symptomatology in young adults with HIV
仔细检查年轻艾滋病毒感染者抑郁症状背后的神经免疫调节机制
- 批准号:
10370250 - 财政年份:2021
- 资助金额:
$ 21.55万 - 项目类别:
Scrutinizing neuro-immune regulatory mechanisms underlying depressive symptomatology in young adults with HIV
仔细检查年轻艾滋病毒感染者抑郁症状背后的神经免疫调节机制
- 批准号:
10487540 - 财政年份:2021
- 资助金额:
$ 21.55万 - 项目类别:
A Clinical Laboratory with Integrated Neuroscience (CLIN) for Early Evaluation of Medications for Substance Use Disorders
综合神经科学 (CLIN) 临床实验室,用于药物滥用障碍药物的早期评估
- 批准号:
10348202 - 财政年份:2020
- 资助金额:
$ 21.55万 - 项目类别:
Efficacy of buprenorphine and XR-naltrexone combination for relapse prevention in opioid use disorder
丁丙诺啡和 XR-纳曲酮组合预防阿片类药物使用障碍复发的功效
- 批准号:
9738472 - 财政年份:2020
- 资助金额:
$ 21.55万 - 项目类别:
A Clinical Laboratory with Integrated Neuroscience (CLIN) for Early Evaluation of Medications for Substance Use Disorders
综合神经科学 (CLIN) 临床实验室,用于药物滥用障碍药物的早期评估
- 批准号:
10576815 - 财政年份:2020
- 资助金额:
$ 21.55万 - 项目类别: