GlyCORE: Glycoscience Center of Research Excellence

GlyCORE：糖科学卓越研究中心

• 批准号: 10165743
• 负责人: SAMIR A ROSS
• 金额: $ 210.8万
• 依托单位: UNIVERSITY OF MISSISSIPPI
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-15 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10165743
• 关键词: Address; Affect; Alabama; Area; Arkansas; Biochemistry and Cellular Biology; Bioinformatics; Biological; Biomedical Research; Biophysics; Carbohydrates; Cell Communication; Cells; Centers of Research Excellence; Chemicals; Chemistry; Chromatography; Communities; Confocal Microscopy; Core Facility; Data Analyses; Destinations; Development; Discipline; Energy Metabolism; Faculty; Faculty Recruitment; Financial Support; Funding; Future; Glycobiology; Glycosides; Health; Human; Image; Immunohistochemistry; In Vitro; International; Kentucky; Lectin; Louisiana; Mass Spectrum Analysis; Mentors; Mentorship; Mississippi; Missouri; Modernization; NMR Spectroscopy; Natural Products; Nature; Neurosciences Research; Participant; Pharmacologic Substance; Pharmacology; Phase; Physiological; Pilot Projects; Play; Polysaccharides; Program Development; Protein-Carbohydrate Interaction; Proteins; Publishing; Recording of previous events; Regulation; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resolution; Resources; Role; Science; Services; Structure; Teacher Professional Development; Tennessee; United States National Academy of Sciences; United States National Institutes of Health; Universities; Work; base; biological systems; career; computational chemistry; experience; faculty support; glycation; human disease; improved; in vivo; innovation; instrumentation; interest; meetings; member; programs; recruit; response; simulation; symposium; tool; tool development

Project Summary/Abstract The University of Mississippi proposes to establish the Glycoscience Center of Research Excellence (GlyCORE), a Phase I Center of Biomedical Research Excellence. Glycoscience is an essential and rapidly emerging field of biomedical science, and the challenging nature of glycoscience research requires tools and expertise that are not commonly found in the biomedical research community. Moreover, the biomedical community is rapidly growing to appreciate the essential role of carbohydrates, with researchers outside of the self-identified “glycoscience” community finding themselves faced with addressing challenging questions in glycoscience as part of the course of their biomedical researchers. GlyCORE will develop and provide resources and expertise in glycoscience to both core glycoscience researchers as well as researchers who encounter questions in glycoscience in the course of their biomedical research programs. GlyCORE will serve researchers at both the University of Mississippi and the Mid-South community through three mechanisms: a Faculty Development program, the establishment of three Research Cores to support glycoscience research, and the establishment of local and regional meetings focusing on questions in glycoscience. GlyCORE's Faculty Development program includes the support of four Junior Investigators establishing their careers in various disciplines in glycoscience. This program includes financial support of the investigators' research efforts, a formal mentoring program, and priority subsidized access to University of Mississippi core facilities. GlyCORE will also support smaller developmental projects through a Pilot Project Program, including financial support and prioritized access to core facilities. GlyCORE's Faculty Development program will also promote recruitment of glycoscience faculty to the University of Mississippi, including the recruitment of a mid-career carbohydrate synthetic chemist to help support expanded services in GlyCORE during Phase II. GlyCORE's Research Cores will establish three new core capabilities at the University of Mississippi that are essential for modern glycoscience: an Analytical and Biophysical Core supporting high resolution chromatography and mass spectrometry analyses; an Imaging Core supporting confocal microscopy with lectin-based and anti- carbohydrate immunohistochemistry imaging; and a Computational and Bioinformatics Core supporting simulations and bioinformatics data analysis to support glycoscience and structural glycobiology. Finally, GlyCORE will establish the University of Mississippi as a regional center for glycoscience in the Mid-South. GlyCORE will host an annual Mid-South Glycoscience Meeting with subsidized access to regional participants, and will host both an annual UM Glycoscience Symposium and monthly glycoscience meetings to highlight the role of glycoscience at the University of Mississippi. Together, these efforts will establish a core of experienced and nationally competitive young faculty in glycoscience, supported by modern research infrastructure and promoted to the glycoscience community as the glycoscience destination in the Mid-South.

项目摘要/摘要 密西西比大学的提议建立了卓越研究中心 （Glycore），I阶段生物医学研究卓越中心。糖科学是必不可少的 生物医学科学的新兴领域以及糖科学研究的挑战性质需要工具和 在生物医学研究界没有常见的专业知识。而且，生物医学 社区正在迅速发展，以欣赏碳水合物的重要作用，研究人员在 自我识别的“糖科学”社区发现自己面临着解决挑战问题的 作为其生物医学研究人员过程的一部分，糖科学。聚糖将开发并提供 核科学研究人员以及研究人员的资源和专业知识 在其生物医学研究计划的过程中，糖科学中会遇到问题。聚糖将服务 密西西比大学和中南社区的研究人员通过三种机制： 教师发展计划，建立三个研究核心以支持糖科学研究， 以及建立本地和区域会议，重点介绍了糖科学中的问题。 Glycore的 教师发展计划包括四名初级调查员的支持 糖科学中的各种学科。该计划包括调查人员研究的财政支持 努力，正式的心理计划以及优先获得密西西比大学核心设施的优先访问。 Glycore还将通过试点项目计划支持较小的发展项目，包括财务 支持并优先访问核心设施。 Glycore的教师发展计划也将促进 招募糖科学教师到密西西比大学，包括招募中期职业者 碳水化合物合成化学家，以帮助在II期期间支持Glycore的扩展服务。 Glycore的 研究核心将在密西西比大学建立三个新的核心能力，这对于 现代性糖科学：一种分析和生物物理核心，支持高分辨率色谱和 质谱分析；基于讲座的和抗 - 碳水化合物免疫组织化学成像；以及一个计算和生物信息学核心支持 模拟和生物信息学数据分析以支持糖性和结构性糖生物学。最后， Glycore将建立密西西比大学，成为中南部的糖科学区域中心。 Glycore将举办一次年度中南期聚糖会议，并获得与区域参与者的补贴， 并将举办一年一度的UM糖科学研讨会和每月的糖科学会议，以突出显示 密西西比大学糖科学的作用。这些努力将共同建立经验的核心 以及全国有竞争力的年轻教师，在现代研究基础设施和 作为中南部的糖科学目的地晋升为糖科学界。