Center for Cancer Control in Persistent Poverty Areas (C3P2)

持续贫困地区癌症防治中心（C3P2）

• 批准号: 10660380
• 负责人: MONA N. FOUAD
• 金额: $ 193.79万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-15 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10660380
• 关键词: Achievement; Address; Adoption; Affect; Alabama; Area; Attention; Behavior; Behavioral; Cancer Burden; Cancer Center; Cancer Control; Cancer Control Research; Censuses; Collaborations; Colorectal Cancer; Common Data Element; Communities; Complex; County; Development; Dissemination and Implementation; Education; Ensure; Environment; Evaluation; Evidence based practice; Geographic Locations; Goals; Health Promotion; Health behavior change; High Prevalence; Incidence; Individual; Infrastructure; Institution; Intervention; Knowledge; Leadership; Malignant Neoplasms; Malignant neoplasm of prostate; Measures; Mentorship; Modeling; Monitor; National Cancer Institute; Obesity; Obesity associated cancer; Outcome; Personal Satisfaction; Physical environment; Pilot Projects; Population; Positioning Attribute; Poverty; Poverty Areas; Prevention; Research; Research Methodology; Research Personnel; Research Project Grants; Resources; Risk Factors; Role; Rural; Rural Community; Social Environment; Stress; System; Training; Universities; University of Alabama at Birmingham Cancer Center; Work; anticancer research; cancer health disparity; cancer prevention; cancer risk; career; community engagement; community living; community partnership; data tools; early experience; effectiveness testing; efficacious intervention; evidence base; experience; health care availability; health care service utilization; improved; inner city; innovation; malignant breast neoplasm; mortality; mortality risk; multidisciplinary; neighborhood disadvantage; poor communities; prevent; program dissemination; programs; social; social cohesion; social health determinants; social structure; supportive environment; survivorship; synergism; therapy design; tool; Achievement; Address; Adoption; Affect; Alabama; Area; Attention; Behavior; Behavioral; Cancer Burden; Cancer Center; Cancer Control; Cancer Control Research; Censuses; Collaborations; Colorectal Cancer; Common Data Element; Communities; Complex; County; Development; Dissemination and Implementation; Education; Ensure; Environment; Evaluation; Evidence based practice; Geographic Locations; Goals; Health Promotion; Health behavior change; High Prevalence; Incidence; Individual; Infrastructure; Institution; Intervention; Knowledge; Leadership; Malignant Neoplasms; Malignant neoplasm of prostate; Measures; Mentorship; Modeling; Monitor; National Cancer Institute; Obesity; Obesity associated cancer; Outcome; Personal Satisfaction; Physical environment; Pilot Projects; Population; Positioning Attribute; Poverty; Poverty Areas; Prevention; Research; Research Methodology; Research Personnel; Research Project Grants; Resources; Risk Factors; Role; Rural; Rural Community; Social Environment; Stress; System; Training; Universities; University of Alabama at Birmingham Cancer Center; Work; anticancer research; cancer health disparity; cancer prevention; cancer risk; career; community engagement; community living; community partnership; data tools; early experience; effectiveness testing; efficacious intervention; evidence base; experience; health care availability; health care service utilization; improved; inner city; innovation; malignant breast neoplasm; mortality; mortality risk; multidisciplinary; neighborhood disadvantage; poor communities; prevent; program dissemination; programs; social; social cohesion; social health determinants; social structure; supportive environment; survivorship; synergism; therapy design; tool

OVERALL ABSTRACT Cancer mortality is higher in areas of the US affected by Persistent Poverty (PP) compared to areas in which poverty has not persisted for decades, especially for obesity-related cancers like breast, prostate, and colorectal cancer. While reasons may be multifaceted, the role of social determinants of health (SDH) cannot be overlooked, including aspects of the Living Environments (e.g., physical and social) and their “downstream” effects on behaviors that impact health promotion and increase cancer risk and mortality. In 2021, Alabama ranked 8th in the US for poverty. The state includes some of the most impoverished inner-city and rural communities in the nation, and thus a considerable number of both urban and rural Census Tracts (CTs) identified as PP areas by the National Cancer Institute (NCI). The overall goal of the University of Alabama at Birmingham (UAB) Center for Cancer Control in Persistent Poverty Areas (C3P2) is to reduce the burden of cancer and cancer disparities in PP areas by expanding research and research capacity through implementation and evaluation of multilevel interventions to improve cancer outcomes across the cancer control continuum from prevention to survivorship. The C3P2 goal will be achieved through: 1) Establishment and support of two transdisciplinary, multi-level, multi-domain research projects to adapt, implement, and evaluate multilevel interventions across the cancer control continuum from prevention to survivorship, as well as pilot projects through a Developmental Core; 2) Establishment of a coordinated C3P2 infrastructure to support and strengthen the C3P2 research agenda by: a) providing overall integrated management and comprehensive evaluation, b) providing common research resources and measures to promote project integration and collaboration (Administrative and Research and Methods Cores); 3) Development of a pipeline of investigators for cancer control research in PP areas by providing training, support, and research experience opportunity to early career investigators (Career Enhancement Core); 4) Academic-community partnership building with establishment of a Community Advisory Board and engagement of Community COaCHes to support innovative and salient research in the community, and monitoring and evaluation to ensure achievement of proposed goals. (Administrative Core). Our multi-disciplinary team of established and early career investigators, working in a supportive environment with the resources and commitment to address and challenges in PP areas to cancer prevention and control, are well positioned to make an impact in PP communities of Alabama and improve cancer outcomes. The C3P2 will serve as a model to improve cancer prevention and control for other PP areas in Alabama and other states.

总体抽象 与持续贫困（PP）影响的美国地区的癌症死亡率更高 贫困已经存在数十年了，尤其是对于肥胖相关的癌症，例如乳腺癌，前列腺和大肠癌 癌症。虽然原因可能是多方面的，但社会决定者的健康（SDH）的作用不能是 被忽视，包括生活环境的各个方面（例如，身体和社会）及其“下游” 对影响促进健康并增加癌症风险和死亡率的行为的影响。 2021年，阿拉巴马州 在美国排名第8位。该州包括一些最贫穷的市中心和正常 全国社区，因此，城市和粗糙的人口普查区（CTS）的考虑数量 由国家癌症研究所（NCI）确定为PP地区。阿拉巴马大学的总体目标 伯明翰（UAB）持续贫困地区（C3P2）的癌症控制中心（C3P2）是为了减少燃烧 通过通过扩大研究和研究能力的癌症和癌症分布 实施和评估多层干预措施以改善癌症控制的癌症结果 从预防到生存的连续体。 C3P2目标将通过：1）建立和 支持两个跨学科的多层次，多域研究项目，以适应，实施和评估 从预防到生存的整个癌症控制连续性的多级干预措施以及飞行员 通过发展核心项目； 2）建立协调的C3P2基础设施以支持和 加强C3P2研究议程：a）提供整体综合管理和全面 评估，b）提供共同的研究资源和措施，以促进项目整合和 协作（行政和研究与方法核心）； 3）开发研究人员的管道 通过提供培训，支持和研究经验的机会，用于PP领域的癌症控制研究 早期职业调查人员（职业增强核心）； 4）与 建立社区顾问委员会和社区教练的参与，以支持创新 以及社区中的显着研究，并监视和评估以确保实现拟议 目标。 （行政核心）。我们由成熟和早期职业调查员组成的多学科团队，工作 在受支持的环境中，资源和致力于应对和应对PP领域的挑战 预防癌症和控制，有能力在阿拉巴马州的PP社区产生影响 改善癌症结果。 C3P2将作为改善预防癌症和控制其他的模型 阿拉巴马州和其他州的PP地区。