GlyCORE: Glycoscience Center of Research Excellence

GlyCORE：糖科学卓越研究中心

• 批准号: 10399724
• 负责人: SAMIR A ROSS
• 金额: $ 10.98万
• 依托单位: UNIVERSITY OF MISSISSIPPI
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-15 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10399724
• 关键词: Address; Affect; Bioinformatics; Biomedical Research; Biophysics; Carbohydrates; Centers of Research Excellence; Chromatography; Communities; Confocal Microscopy; Core Facility; Data Analyses; Destinations; Development; Discipline; Faculty; Financial Support; Funding; Glycobiology; Health; Human; Image; Immunohistochemistry; Lectin; Mass Spectrum Analysis; Mentors; Mississippi; Modernization; Nature; Participant; Phase; Pilot Projects; Program Development; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resolution; Resources; Role; Science; Services; Structure; Teacher Professional Development; Universities; Work; base; career; experience; meetings; programs; recruit; simulation; symposium; tool

Project Summary/Abstract The University of Mississippi proposes to establish the Glycoscience Center of Research Excellence (GlyCORE), a Phase I Center of Biomedical Research Excellence. Glycoscience is an essential and rapidly emerging field of biomedical science, and the challenging nature of glycoscience research requires tools and expertise that are not commonly found in the biomedical research community. Moreover, the biomedical community is rapidly growing to appreciate the essential role of carbohydrates, with researchers outside of the self-identified “glycoscience” community finding themselves faced with addressing challenging questions in glycoscience as part of the course of their biomedical researchers. GlyCORE will develop and provide resources and expertise in glycoscience to both core glycoscience researchers as well as researchers who encounter questions in glycoscience in the course of their biomedical research programs. GlyCORE will serve researchers at both the University of Mississippi and the Mid-South community through three mechanisms: a Faculty Development program, the establishment of three Research Cores to support glycoscience research, and the establishment of local and regional meetings focusing on questions in glycoscience. GlyCORE's Faculty Development program includes the support of four Junior Investigators establishing their careers in various disciplines in glycoscience. This program includes financial support of the investigators' research efforts, a formal mentoring program, and priority subsidized access to University of Mississippi core facilities. GlyCORE will also support smaller developmental projects through a Pilot Project Program, including financial support and prioritized access to core facilities. GlyCORE's Faculty Development program will also promote recruitment of glycoscience faculty to the University of Mississippi, including the recruitment of a mid-career carbohydrate synthetic chemist to help support expanded services in GlyCORE during Phase II. GlyCORE's Research Cores will establish three new core capabilities at the University of Mississippi that are essential for modern glycoscience: an Analytical and Biophysical Core supporting high resolution chromatography and mass spectrometry analyses; an Imaging Core supporting confocal microscopy with lectin-based and anti- carbohydrate immunohistochemistry imaging; and a Computational and Bioinformatics Core supporting simulations and bioinformatics data analysis to support glycoscience and structural glycobiology. Finally, GlyCORE will establish the University of Mississippi as a regional center for glycoscience in the Mid-South. GlyCORE will host an annual Mid-South Glycoscience Meeting with subsidized access to regional participants, and will host both an annual UM Glycoscience Symposium and monthly glycoscience meetings to highlight the role of glycoscience at the University of Mississippi. Together, these efforts will establish a core of experienced and nationally competitive young faculty in glycoscience, supported by modern research infrastructure and promoted to the glycoscience community as the glycoscience destination in the Mid-South.

项目概要/摘要 密西西比大学提议建立糖科学卓越研究中心 （GlyCORE）是一期生物医学卓越研究中心，是一个重要且快速发展的中心。 生物医学科学的新兴领域以及糖科学研究的挑战性本质需要工具和 生物医学研究界不常见的专业知识。 人们正在迅速认识到碳水化合物的重要作用，并且外部的研究人员 自我认定的“糖科学”社区发现自己面临着解决具有挑战性的问题 糖科学作为其生物医学研究人员课程的一部分将开发和提供。 为核心糖科学研究人员以及以下研究人员提供糖科学方面的资源和专业知识 GlyCORE 将在其生物医学研究项目中遇到糖科学方面的问题。 密西西比大学和中南社区的研究人员通过三种机制： 教师发展计划，建立三个研究核心以支持糖科学研究， 建立重点关注糖科学问题的地方和区域会议。 教师发展计划包括支持四名初级研究员在以下领域建立自己的职业生涯 该计划包括对研究人员研究的财政支持。 努力、正式的指导计划以及优先获得密西西比大学核心设施的补贴。 GlyCORE 还将通过试点项目计划支持较小的开发项目，包括财务 GlyCORE 的教师发展计划也将促进支持和优先使用核心设施。 密西西比大学糖科学系教师的招聘，包括职业生涯中期的招聘 碳水化合物合成化学家在 GlyCORE 第二阶段期间帮助扩大 GlyCORE 的支持服务。 研究核心将在密西西比大学建立三项新的核心能力，这对于 现代糖科学：支持高分辨率色谱和生物物理的分析和生物物理核心 质谱分析；支持基于凝集素和抗共聚焦显微镜的成像核心 碳水化合物免疫组织化学成像；以及计算和生物信息学核心支持 模拟和生物信息学数据分析支持糖科学和结构糖生物学。 GlyCORE 将建立密西西比大学作为中南部糖科学区域中心。 GlyCORE 将主办一年一度的中南糖科学会议，并为区域参与者提供资助， 并将举办一年一度的密歇根大学糖科学研讨会和每月糖科学会议，以强调 这些努力将共同建立一个经验丰富的核心团队，以发挥糖科学在密西西比大学的作用。 以及在现代研究基础设施和支持下，糖科学领域具有全国竞争力的年轻教师队伍 晋升为糖科学界，作为中南部糖科学目的地。