P 3: PSYCHOACTIVITY OF CANNABINOIDS & INTERACTIO W/ DELTA-9-TETRAHYDROCANNABINOL

P 3：大麻素的心理活性

• 批准号: 7720413
• 负责人: SAMIR A ROSS
• 金额: $ 19.68万
• 依托单位: UNIVERSITY OF MISSISSIPPI
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7720413
• 关键词: Biological; Cannabinoids; Cannabis; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Individual; Institution; Research; Research Personnel; Resources; Source; Tetrahydrocannabinol; United States National Institutes of Health; endogenous cannabinoid system

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The specific aims of this project are as follows: 1. Isolate and structurally analyze different cannabinoids, especially from the polyhydroxylated cannabitriol group and non-cannabinoid phenolic compounds from cannabis extract, whose biological activity is unknown. 2. Confirm that the mechanism of action of the isolated compounds involves an interaction with the endogenous cannabinoid system. 3. Study the psychoactivity of the isolated compounds and compare it with that of delta-9-THC. 4. Study the interaction of delta-9-THC with the individual isolated compounds and determine their contribution to the overall biological activities of cannabis.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此，可以在其他清晰的条目中表示。列出的机构是 对于中心，这不一定是调查员的机构。 该项目的具体目的如下： 1。分离株和结构分析不同的大麻素，尤其是来自多羟基化大麻基团和非大麻素酚类化合物的大麻提取物，其生物学活性尚不清楚。 2。确认分离化合物的作用机理涉及与内源性大麻素系统的相互作用。 3。研究孤立化合物的心理活性，并将其与delta-9-thc的心理活性进行比较。 4。研究delta-9-thc与单个孤立化合物的相互作用，并确定它们对大麻整体生物学活性的贡献。