A Period Seroprevalence (SARS-CoV-2) Survey in MHCCN Cancer Healthcare Workers (HCWs) Providing Patient Care during the Height of the Outbreak: A Registry Study

对在疫情高峰期提供患者护理的 MHCCN 癌症医护人员 (HCW) 进行的期间血清阳性率 (SARS-CoV-2) 调查：登记研究

• 批准号: 10166146
• 负责人: Scot C Remick
• 金额: $ 12.89万
• 依托单位: MAINEHEALTH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-13 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10166146
• 关键词: 2019-nCoV; Academic Medical Centers; Address; Adult Respiratory Distress Syndrome; Aircraft; Antibodies; Antibody Response; Award; Biosensor; Blood specimen; COVID-19; Cancer Patient; Caring; Centers for Disease Control and Prevention (U.S.); China; Clinical; Clinical Trials; Coronavirus; Data; Disease; Disease Outbreaks; Enrollment; Ensure; Environment; Epidemiology; Equipment; Etiology; Future; Health; Health Personnel; Health system; Height; Immunocompromised Host; Immunoglobulin G; Immunoglobulin M; Individual; Infection; Inpatients; Investigation; Laboratories; Life; Light; Location; Longevity; Maine; Malignant Neoplasms; Measures; Medical History; Medical Oncologist; Nurses; Occupational; Occupational Exposure; Oncology; Outcome; Outpatients; Participant; Patient Care; Patients; Perception; Persons; Pharmacists; Plasma; Pneumonia; Population; Prevalence; Procedures; Provider; Public Health; RNA; Radiation Oncologist; Radiation Therapist; Registries; Reverse Transcriptase Polymerase Chain Reaction; Risk; Route; Rural; Rural Community; Rural Health; SARS coronavirus; Sailor; Sampling; Seasons; Seminal; Serologic tests; Serological; Seroprevalences; Services; Ships; Social Workers; Source; South Korea; Surgical Oncologist; Surveys; System; Testing; Virus; base; cancer care; care providers; chemotherapy; cohort; community setting; comorbidity; coronavirus disease; emotional distress; experience; first responder; flu; follow-up; improved; insight; medical supply; molecular diagnostics; novel coronavirus; novel virus; older patient; pandemic disease; parent grant; pathogen; patient population; recruit; response; rural cancer care; scale up; seroconversion; seropositive; sound; surveillance study; transmission process; viral transmission

In December 2019, the emergence of an as yet uncharacterized pneumonia in Wuhan, China heralded the onset of the coronavirus pandemic caused by Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS-CoV-2). The etiology and disease profile, aka Coronavirus Disease-2019 (COVID-19), has been quickly elucidated; though there is considerable lack of understanding of viral transmission. Public health measures to mitigate and contain the outbreak are hampered by scarcity and scaling up testing. The virus is among the most contagious in our lifetimes and thought to be primarily transmitted by droplet infection. Viral transmission also occurs by airborne routes and during asymptomatic periods of infection, which complicates public health measures. This is further compounded by lack of Personal Protective Equipment (PPE) and different strategies for use. These realities place Healthcare Workers (HCWs) at risk providing care to known infected patients and Persons Under Investigation (PUIs) with high suspicion of COVID-19. We propose a hypothesis-driven period sero-prevalence study of SARS-CoV-2 in MaineHealth Cancer Care Network (MHCCN) cancer Healthcare Workers (HCWs) at a sizeable rural health system and academic medical center. Our study is predicated on the lack of sound sero-epidemiological data to define occupational exposure and risk of SARS-CoV-2 infection in our cancer providers. We anticipate brisk recruitment of our cancer HCWs (Aim 1) and roll-out of a sero-antibody (IgG/IgM) test (Aim 2) to determine exposure. Brief clinical and occupational surveys will be completed. This cohort is invaluable to sustain and provide information on the SARS-CoV-2-transmission dynamics that will guide continued response to this pandemic, especially with an anticipated second wave that will inform cancer care in the rural community setting. This project is submitted in response to NOT-CA-20-0421 and is closely integrated and tethered to MaineHealth Lifespan NCORP (1UG1 CA239771-01) the parent grant that was submitted and subsequently awarded under PA-18-591.

2019年12月，中国在武汉尚未表征的肺炎出现，预示着由严重急性呼吸综合症冠状病毒-2（SARS-COV-2）引起的冠状病毒大流行病的发作。病因和疾病特征，又名冠状病毒疾病，2019年（Covid-19），已迅速阐明。尽管缺乏对病毒传播的理解。稀缺和扩大测试的限制，以减轻和遏制爆发的公共卫生措施受到阻碍。该病毒是我们一生中最具传染性的病毒之一，并且被认为主要是通过液滴感染传播的。病毒传播还通过空中路线和无症状的感染期间发生，这使公共卫生措施复杂化。由于缺乏个人防护设备（PPE）和不同的使用策略，这进一步加剧了这一点。这些现实使医护人员（HCWS）处于风险的风险中，以高度怀疑COVID-19，为已知的受感染患者和正在调查的患者（PUI）提供护理。我们在Mainehealth Cancer Care网络（MHCCN）癌症医疗保健工作者（HCWS）中提出了一个假设驱动的时期的SARS-COV-2时期研究。我们的研究基于缺乏声音血清流行学数据来定义我们的癌症提供者中的职业暴露和SARS-COV-2感染的风险。我们预计我们的癌症HCW（AIM 1）和推出血清抗体（IgG/IgM）测试（AIM 2）可以轻快募集。简短的临床和职业调查将完成。该队列是维持和提供有关SARS-COV-2传输动态的信息的宝贵的，这些动态将指导对这一大流行的持续反应，尤其是预期的第二波浪潮，该浪潮将在农村社区环境中为癌症护理提供信息。该项目是针对非CA-20-0421提交的，并紧密整合并束缚在Mainhealth Lifespan ncorp（1UG1 CA239771-01）中，该父母赠款并随后根据PA-18-591授予。