Cancer and tobacco control training and research across the lifespan in Kenya

肯尼亚整个生命周期的癌症和烟草控制培训和研究

• 批准号: 8531371
• 负责人: Scot C Remick
• 金额: $ 20.31万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-10 至 2016-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8531371
• 关键词: Acquired Immunodeficiency Syndrome; Address; Award; Cancer Burden; Cancer Control; Centers for Disease Control and Prevention (U.S.); Cerebrovascular Disorders; Child; Chronic; Clinical Trials; Collaborations; Communicable Diseases; Country; Development; Educational process of instructing; Electronics; Evidence based intervention; Feeds; Foundations; Funding; Goals; Grant; Health; Health Policy; Health Sciences; Health Services Accessibility; Hospital Referrals; Hospitals; Indiana; International; Kenya; Laboratories; Lead; Link; Longevity; Malignant Neoplasms; Medical Research; Modeling; Morbidity - disease rate; Online Systems; Pathologist; Pathology; Population-Based Registry; Public Health; Research; Research Infrastructure; Research Institute; Research Personnel; Research Project Grants; Research Training; Site; Solid; Time; Tobacco Use Cessation; Tobacco use; Training; Training Programs; Translating; Tumor Pathology; Universities; West Virginia; Writing; cancer care; cancer diagnosis; college; community intervention; end of life; experience; hospice environment; human subject protection; member; mortality; multidisciplinary; next generation; programs; public policy on tobacco; responsible research conduct; symposium; tobacco control; tumor; virology

DESCRIPTION (provided by applicant): The burden of cancer and tobacco consumption are major causes of morbidity and mortality in Kenya, a country with limited research infrastructure and significant scarcity to address these ever increasing chronic, non- communicable disease (NCD) threats to public health. Building on a near 15-year long research collaboration in Nairobi; a 20-year long academic partnership Academic Model Providing Access to Healthcare in Eldoret; capitalizing on a current NCI D43 training grant devoted to AIDS malignancy that is building critical pathology, tumor virology and clinical trials capacity; other NCI and CDC-funded research projects; an international team of highly interactive and experienced investigators led by Drs. Scot Remick, West Virginia University (WVU) and his senior Kenyan collaborator Walter Mwanda, University of Nairobi (UoN); Dr. Geoffrey Mutuma at Kenya Medical Research Institute (KEMRI); Dr. Brigid Sirengo at Nairobi Hospice; Dr. Patrick Loehrer at Indiana University (IU) and his senior Kenyan collaborator Dr. Naftali Busakhala, Moi University (MU) are partnering to develop sustainable research capacity for cancer and tobacco control in Kenya across the lifespan. Our training program will link for the first time the 5 essential academic medical and research centers in Kenya: UoN College of Health Sciences and affiliated Kenyatta National Hospital (KNH) in Nairobi; KEMRI; and the MU College of Health Sciences and affiliated Moi Teaching and Referral Hospital (MTRH) in Eldoret. The overall goal of our D43 training program is to bridge existing research capacity in Kenya, enabling strategic and inclusive multidisciplinary teams that will provide a solid foundation for development and implementation of evidence-based interventions relevant to cancer and tobacco control that will translate into Kenyan public health policy. The essential objectives are to strengthen the infrastructure for cancer and tobacco control in Kenya such that by the end of the 5-year Fogarty award highly interactive teams of investigators and research personnel will: (1) register cancer and other NCD entities (e.g., cerebrovascular disease) in population-based registries to inform national health officials and research programs; (2) develop effective tobacco cessation and control strategies for community intervention(s) and further frame tobacco policy; (3) support pathology research projects for successful completion of the MMed(Pathology) degree program to develop the next generation of trained pathologists for cancer diagnosis and lead multidisciplinary tumor boards; and (4) build research capacity for end-of-life cancer care and generate effective evidence-based interventions especially for children with cancer. Common training themes include: (1) the bulk of the training will be on-site in Kenya, which allows us to provide direct training for more members of our health teams; (2) address both intellectual - "people" and technical - "laboratory" capacities; (3) provide a variety of short, medium and long-term, "south-to-south", and electronic/web-based training coursework taking advantage of a newly fit-up electronic conference room in the Department of Pathology at UoN; and (4) provide training for the responsible conduct of research, protections of human subjects, and scientific/grants writing that feeds into a pilot research awards mechanism.

描述（由申请人提供）：癌症和烟草消费的负担是肯尼亚发病率和死亡率的主要原因，肯尼亚是一个研究基础设施有限的国家，可解决这些持续增长的慢性，非传染病（NCD）威胁公众的威胁健康。建立在内罗毕的近15年的研究合作；一个长达20年的学术合作伙伴学术模型，可在Eldoret获得医疗保健；利用当前的NCI D43培训补助金，该培训赠款致力于建立关键病理学，肿瘤病毒学和临床试验能力的AIDS恶性肿瘤；其他NCI和CDC资助的研究项目；由DRS领导的一支由高度互动和经验丰富的调查员组成的国际团队。西弗吉尼亚大学（WVU）的苏格兰人雷米克和他的肯尼亚高级合作者沃尔特·姆万达（UON）；肯尼亚医学研究所（Kemri）的Geoffrey Mutuma博士；内罗毕临终关怀的Brigid Sirengo博士；印第安纳大学（IU）的Patrick Loehrer博士和他的肯尼亚高级合作者Naftali Busakhala博士，MOI大学（MU）正在合作，在整个寿命中在肯尼亚开发可持续的癌症和烟草控制能力。我们的培训计划将首次链接肯尼亚的5个基本学术医学和研究中心：内罗毕的UON卫生科学与附属学院肯雅塔国家医院（KNH）； Kemri;以及Eldoret的MU卫生科学与附属MOI教学与转诊医院（MTRH）。我们D43培训计划的总体目标是弥合肯尼亚的现有研究能力，实现战略和包容性的多学科团队，这些团队将为开发和实施与癌症和烟草控制相关的基于证据的干预措施提供稳固的基础，这些干预措施将转化为肯尼亚公众卫生政策。基本目标是加强肯尼亚的癌症和烟草控制的基础设施，使得在5年Fogarty Award结束时，高度互动的调查人员和研究人员将：（1）注册癌症和其他NCD实体（例如，脑血管造口癌症和其他NCD实体疾病）在基于人群的登记处，以告知国家卫生官员和研究计划； （2）制定有效的烟草戒烟和控制社区干预的策略，并进一步制定烟草政策； （3）支持成功完成MMED（病理）学位计划的病理研究项目，以开发下一代训练有素的病理学家进行癌症诊断和铅多学科肿瘤委员会； （4）建立研究能力，以实现生命终止癌症护理，并为癌症儿童提供有效的基于证据的干预措施。常见的培训主题包括：（1）大部分培训将在肯尼亚现场，这使我们能够为更多的卫生团队成员提供直接培训； （2）涉及智力 - “人”和技术 - “实验室”能力； （3）提供各种短期，中和长期的“南到南”，以及基于电子/网络的培训课程，利用UON病理学系的新装修电子会议室的优势； （4）为负责任的研究，人类受试者的保护以及科学/赠款写作提供培训，这些培训以试点研究奖励机制为基础。