Developing Research Capacity for AIDS Malignancy in Kenya

发展肯尼亚艾滋病恶性肿瘤的研究能力

• 批准号: 8009569
• 负责人: Scot C Remick
• 金额: $ 53.83万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-09 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8009569
• 关键词: AIDS Malignancy Consortium; AIDS related cancer; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Africa South of the Sahara; African; African Burkitt' s lymphoma; Area; Clinical; Clinical Research; Clinical Trials; Collaborations; Developed Countries; Diagnostics Research; EBV-associated malignancy; Ensure; Epidemiologist; Epidemiology; Etiology; Future; Goals; Healthcare; Hematologist; Hospitals; Institution; International; Kenya; Leadership; Link; Lymphoma; Malignant Neoplasms; Medical; Medical Research; Ohio; Oncologist; Pathogenesis; Pathologist; Pathology; Pediatric Hospitals; Peer Review; Performance; Research; Research Activity; Research Institute; Research Personnel; Research Support; Research Training; Resources; Rosemary; Site; Therapeutic; Time; Tissues; Training; Training Programs; Translational Research; United States National Institutes of Health; Universities; Viral; Virus; West Virginia; base; cancer specimen resource; diagnostic accuracy; experience; interest; multidisciplinary; neoplasm resource; programs; repository; tool; translational study; tumor; virology

DESCRIPTION (provided by applicant): An experienced international team of investigators building upon a decade-long collaboration are partnering to develop sustainable research capacity for studies on HIV-associated malignancies in Kenya. Our proposal provides an unprecedented opportunity for our partners - the University of Nairobi (UoN), Kenyatta National Hospital (KNH), and the Kenya Medical Research Institute (KEMRI) - 3 highly respected African institutions, enjoined on a dedicated AIDS malignancy NCl collaborative project for the first time. Our fundamental strategic approach is to let clinical studies drive our training program. We have developed 3 highly interactive and inter-dependent training aims focusing on: 1) diagnostic and research pathology; 2) tumor virology; and 3) clinical trials, which are vital to ensure a robust translational research program 3 years hence. Our international team is led by Drs. Scot Remick at West Virginia Univ., an AIDS oncologist and clinical trialist (U.S. PI); Leona W. Ayers at Ohio State Univ., HIV/AIDS pathologist; Rosemary Rochford at SUNY Upstate Medical Univ., EBV-associated malignancies and epidemiologist; Walter Mwanda at UoN and KNH, pediatric hematologist and clinical trialist (Kenya Senior Collaborator); and Geoffrey Mutuma at KEMRI, clinical pathologist. Our training program will link to the emerging African trials network and international research agenda led by the NCI-sponsored AIDS Malignancy Consortium (PI: R. Mitsuyasu, CAI21947) under Dr. Remick's leadership; build diagnostic and research pathology and tissue repository capacity to enable tissue-based correlative and translational studies through the NCI-sponsored AIDS Cancer Specimen Resource/Sub-Saharan African Lymphoma Consortium under Dr. Ayers leadership (CA066531); NIH-peer reviewed tumor virology research activities brought to this collaboration by Dr. Rochford's program (CA102667) focusing on strengthening capacity in virus research tools and epidemiological approaches to stimulate and broaden pathologists' and clinicians' interests in research questions and particularly collaborations in AIDS and other viral related tumors; and future NIH research opportunities as they evolve. The overall goal of our training program is to consolidate and strengthen existing capacity in Kenya, which remains a resource-challenged, developing area of the world; and to develop strategic and inclusive multidisciplinary teams that are efficient and productive partners with investigators from developed countries. From our collaboration, we expect to have a well-trained doctoral level and support research staff in place ready to explore questions of diagnostic accuracy, viral etiology, and therapeutic alternatives for AIDS malignancies and other viral tumors. We anticipate serving as a future site in sub-Saharan Africa for research and training in AIDS malignancies and other viral tumors building on our Kenyan-WVU/OSU/SUNY partnership. RELEVANCE: This proposal strengthens capacity for the performance of translational research focusing on AIDS- related malignancies in Kenya, a region of the world with the greatest burden of HIV/AIDS. The training plan builds on "trans-NIH" assets including the NCI-sponsored AIDS Malignancy Consortium, the Mid Region- AIDS & Cancer Resource, and Sub-Saharan Africa Lymphoma Consortium across 3 U.S. and 3 Kenyan academic healthcare institutions to better inform our understanding of pathogenesis, diagnostic accuracy, viral etiology, and therapeutic approach toward AIDS malignancies and other viral tumors.

描述（由申请人提供）：经验丰富的国际调查人员团队在长达十年的合作中建立了合作，以开发可持续的研究能力，以研究肯尼亚与HIV相关的恶性肿瘤研究。我们的提案为我们的合作伙伴提供了前所未有的机会 - 内罗毕大学（UON），肯雅塔国家医院（KNH）和肯尼亚医学研究所（KEMRI）-3个高度尊敬的非洲机构，禁止专用于一个专用的艾滋病NCL协作项目首次。我们的基本战略方法是让临床研究推动我们的培训计划。我们已经开发了3种高度互动和相互依赖的培训，重点是：1）诊断和研究病理； 2）肿瘤病毒学； 3）临床试验，这对于确保3年的强大转化研究计划至关重要。我们的国际团队由博士领导。艾滋病肿瘤学家和临床审判员（美国PI）的西弗吉尼亚大学的苏格兰雷米克（Scot Remick）； HIV/AIDS病理学家俄亥俄州立大学的Leona W. Ayers； SUNY UPSTATE Medical Univ。的迷迭香Rochford，与EBV相关的恶性肿瘤和流行病学家；儿科血液学家兼临床试管员（肯尼亚高级合作者）的UON和KNH的Walter Mwanda；临床病理学家Kemri的Geoffrey Mutuma。我们的培训计划将链接到由NCI赞助的艾滋病恶性财团（PI：R. Mitsuyasu，CAI21947）领导的新兴非洲试验网络和国际研究议程。通过NCI赞助的AIDS癌症标本资源/撒哈拉以下非洲淋巴瘤联盟（CA0666531），建立诊断和研究库库能力，通过NCI赞助的AIDS癌症标本资源/撒哈拉以下非洲淋巴瘤联盟来实现基于组织的相关和翻译研究； NIH-PER审查了Rochford博士计划（CA102667）为这项合作带来的肿瘤病毒学研究活动，重点是增强病毒研究工具的能力和流行病学方法，以刺激和扩大病理学家的兴趣，并特别扩大临床医生在AIDS和AIDS和AIDS中的协作兴趣其他与病毒相关的肿瘤；以及未来的NIH研究机会，随着它们的发展。我们的培训计划的总体目标是巩固和加强肯尼亚的现有能力，肯尼亚仍然是一个受到资源挑战的世界发展中的能力。并建立战略和包容性的多学科团队，这些团队是与发达国家的调查人员有效且富有成效的合作伙伴。从我们的合作中，我们希望拥有训练有素的博士学位，并支持研究人员准备探索诊断准确性，病毒病因和艾滋病恶性肿瘤和其他病毒肿瘤的治疗替代方案的问题。我们预计将在撒哈拉以南非洲作为未来的地点，以在我们的肯尼亚-WVU/OSU/SUNY合作伙伴关系上进行艾滋病恶性肿瘤和其他病毒肿瘤进行研究和培训。相关性：该提案增强了肯尼亚的转化研究的能力，该研究重点是肯尼亚，肯尼亚是世界上最大的艾滋病毒/艾滋病负担。该培训计划以“ Trans-NIH”资产为基础艾滋病和其他病毒肿瘤的发病机理，诊断准确性，病毒病因和治疗方法。