8/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT CHLA

8/21 ABCD-美国联盟：CHLA 研究项目现场

• 批准号: 10157918
• 负责人: Megan Marie Herting
• 金额: $ 18.02万
• 依托单位: CHILDREN'S HOSPITAL OF LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10157918
• 关键词: 10 year old; Academic achievement; Acute; Address; Administrative Supplement; Adolescence; Adolescent; Adolescent Development; Adopted; Affect; Age; Alcohol or Other Drugs use; Area; Behavioral; Biological; Biological Assay; Brain; COVID-19; COVID-19 pandemic; Cellular Phone; Censuses; Cessation of life; Characteristics; Child; Child Health; Chronic stress; Cognition; Collection; Communities; Coronavirus; County; Data; Data Analyses; Data Collection; Development; Dimensions; Disasters; Economics; Employment; Enrollment; Environment; Event; Exposure to; Family; Funding; Home environment; Incidence; Income; Individual; Infection; Infrastructure; Intervention; Lead; Link; Longitudinal Studies; Measurement; Measures; Mental Health; Moods; Movement; National Institute of Drug Abuse; Nature; Neighborhoods; Neuropsychological Tests; Occupations; Outcome; Parents; Participant; Patient Self-Report; Pattern; Policies; Population Density; Prevalence; Prevention; Protocols documentation; Questionnaires; Reporting; Research; Research Project Grants; Resource Informatics; Risk; Risk Factors; Schools; Services; Shock; Site; Social Distance; Social Functioning; Socioeconomic Status; Source; Stress; Structure; Support System; Unemployment; United States; Variant; Viral; Wages; Work; Youth; base; cognitive development; cohort; experience; infrastructure development; lower income families; mortality; neuroimaging; pandemic disease; payment; physical conditioning; protective factors; resilience; response; young adult

The Adolescent Brain Cognitive Development (ABCD) study is the largest long-term study of child health and brain development in the US, consisting of a Coordinating Center, a Data Analysis and Informatics Resource Center, and 21 research sites. The ABCD Study has enrolled a diverse cohort of 11,878 9-10-year-olds and will continue to track their biological and behavioral development through adolescence into young adulthood. All participants receive neuroimaging, neuropsychological testing, bioassays, and detailed youth and parent assessments of substance use, mental health, physical health, and culture and environment. In March 2020, when our participants were ages 11-13, the world became substantially affected by the COVID-19 pandemic, leading to an upheaval in the economy and the lives of almost every family. Most U.S. schools closed to reduce viral spread. Many parents incurred changes in work (e.g., working-from-home, longer shifts, reduced wages, job loss). Some services and support systems became disrupted. And, the number of confirmed cases and deaths have continued to surge. The massive multifaceted impact of this unprecedented event has the potential to affect today’s children for decades to come. Here, we propose to leverage ABCD’s infrastructure, cohort, and existing protocol to rapidly characterize the impacts of the COVID-19 pandemic on each child in the study. In this proposal, we will capitalize on funded (NSF; PI Tapert) and pending supplements to administer queries to all ABCD participants and their parents about the impact of the pandemic on their lives (family level impact) by also incorporating publicly and privately available measures of community-level COVID-19 impacts. For participants’ neighborhoods (e.g., census tract, county, state), we will geocode measures of incidence, spatial distancing, changes in (un)employment, and timing of implementation of state and/or local policies on mitigation practices. By collecting this situational information at the family and community levels as soon as possible, we can use existing ABCD data to examine perturbations in developmental trajectories of brain functioning, cognition, substance use, academic achievement, social functioning, and physical and mental health. Specifically, we will (1) focus on characterizing the nature and variability of the community and regional impact of COVID-19, based on geocoding of ABCD participants’ neighborhoods (i.e., current home address) and (2) determine how community-level and family-level impacts of COVID-19 differentially influence stress, cognition, and mental health during and after the pandemic. We will analyze (1) the interactions between family- and community-specific impacts on ABCD participants’ immediate stress and mental health during the pandemic, (2) the extent to which such potential impacts are associated with each other, and (3) how both community and family factors (e.g., SES, neighborhood characteristics) may serve as protective factors. This unprecedented crisis provides an opportunity to exploit ABCD’s infrastructure and scientific rigor to discern critical dimensions of development not previously envisioned.

青少年脑认知发展（ABCD）研究是对儿童健康和 美国的大脑开发，包括协调中心，数据分析和信息学资源 中心和21个研究站点。 ABCD研究已招募了11,878个9-10岁的潜水员队列， 通过青少年成年，将继续跟踪其生物学和行为发展。 所有参与者都会获得神经影像学，神经心理学测试，生物测定以及详细的青年和父母 评估物质使用，心理健康，身体健康以及文化和环境的评估。 2020年3月 当我们的参与者年龄11-13岁时，世界就会受到19日大流行的实质性影响， 导致经济和几乎每个家庭的生活发生动荡。大多数美国学校都关闭 减少病毒传播。许多父母发生了工作变化（例如，工作中的工作，更长的班次，减少了 工资，失业）。一些服务和支持系统被破坏了。而且，已确认案件的数量 死亡继续激增。这个空前事件的巨大多方面影响具有 几十年来影响当今孩子的潜力。在这里，我们建议利用ABCD的基础设施， 队列和现有协议以快速表征Covid-19的影响对每个孩子的影响 研究。在此提案中，我们将利用资助的（NSF； Pi Tapert），并待在 向所有ABCD参与者及其父母询问大流行对他们生活的影响 （家庭级别的影响）还通过编码公开和私人可用的社区级别措施 COVID-19撞击。对于参与者的社区（例如，人口普查区，县，州），我们将地理位置 事件的措施，空间距离，（联合国）就业的变化以及实施国家的时机 和/或缓解措施的本地政策。通过在家庭中收集这种情况信息 社区级别尽快可以使用现有的ABCD数据来检查 大脑功能，认知，药物使用，学术成就，社会的发展轨迹 功能以及身心健康。具体而言，我们将（1）专注于表征性质和 基于ABCD参与者的地理编码，社区的可变性和Covid-19的区域影响 社区（即当前的家庭住址）和（2）确定社区级别和家庭层面的影响 COVID-19在大流行期间和之后都会差异地影响压力，认知和心理健康。我们将 分析（1）家庭和特定于社区对ABCD参与者立即影响的相互作用 大流行期间的压力和心理健康，（2）这种潜在影响与之相关的程度 彼此之间，以及（3）社区和家庭因素（例如SES，邻里特征）如何 用作受保护的因素。这场空前的危机提供了一个利用ABCD基础设施的机会 和科学严格识别以前没有设想的发展的关键方面。