Urban air pollution and neurobehavioral trajectories in the ABCD study

ABCD 研究中的城市空气污染和神经行为轨迹

• 批准号: 10256619
• 负责人: Megan Marie Herting
• 金额: $ 63.6万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-09 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10256619
• 关键词: 10 year old; 12 year old; Address; Adolescence; Adolescent; Adult; Adverse effects; Affect; Age; Air; Air Pollutants; Air Pollution; American; Animals; Area; Behavior assessment; Behavioral; Brain; Caliber; Carbon; Charge; Child; Childhood; Cities; Cognitive; Communities; Conflict (Psychology); Corpus striatum structure; Crime; Data; Development; Developmental Course; Dorsal; Emotional; Emotions; Enrollment; Environmental Risk Factor; Epidemiology; Exposure to; Family; Geographic Locations; Geography; Health; Heterogeneity; Human; Hybrids; Individual; Intervention; Knowledge; Life; Literature; Longitudinal Studies; Magnetic Resonance Imaging; Maps; Methodology; Modeling; Morphology; Neighborhoods; Neurocognitive; Neuroepidemiology; Neurotoxins; Nitrates; Nitrogen Dioxide; Optimum Populations; Outcome; Outcome Measure; Ozone; Policies; Population; Population Characteristics; Population Heterogeneity; Predisposition; Prefrontal Cortex; Pregnancy; Prevention; Prevention program; Process; Public Health; Recording of previous events; Regulation; Resolution; Rest; Risk Factors; Role; Sampling; Science; Sex Differences; Social Environment; Socioeconomic Status; Structure; Sulfate; Surface; Time; Violence; Visit; Vulnerable Populations; Youth; base; behavior test; boys; brain behavior; brain morphology; cognitive control; cognitive development; cohort; design; developmental neurotoxicity; disadvantaged background; early adolescence; early childhood; emerging adult; emotional behavior; executive function; fine particles; follow-up; girls; gray matter; improved; interest; intervention program; multi-ethnic; multimodality; neurobehavioral; neuroimaging; neurotoxic; neurotoxicity; neurotoxicology; novel; parental involvement; particle; pollutant; preadolescence; prenatal; prospective; protective factors; recruit; resilience; sex; sexual dimorphism; social; social factors; sociodemographics; spatiotemporal; tool; urban area; white matter

Project Summary Fine particulate matter (aerodynamic diameter<2.5 μm; PM2.5) is a novel and ubiquitous environmental neurotoxin affecting neurobehavioral development of millions of American children living in urban areas. However, our review points to several major methodological limitations and critical knowledge gaps in the extant literature, including: 1) the lack of studies with longitudinal brain and behavior assessments; 2) relatively small samples from localized geographical areas; 3) little to no information on long-term cumulative and/or differential timing of exposure across development; and 4) remaining questions regarding the neurotoxicity of PM2.5 exposure on critical neurobehavioral processes that continue to mature across adolescence. Although animal neurotoxicology studies have highlighted the importance of sex, there is only limited epidemiologic evidence for sex difference in PM2.5 neurotoxicity in children. Moreover, brain development is also shaped by family- and community-level social factors, but whether and how air pollution neurotoxicity interacts with the social context remains unclear. This application will leverage the nationwide longitudinal Development (ABCD) study of 9- and 10-year-olds (N=11,873) Adolescent Brain Cognitive to examine prenatal and childhood air pollution exposure effects on neurobehavioral development in boys and girls across 21 U.S. cities. ABCD outcome measures are anchored on the transition to early adolescence because neuromaturation continues from childhood through early adulthood, making such developmental transition periods potentially more vulnerable to environmental insults. Our primary exposure of interest is PM2.5, but advances in well-validated spatiotemporal modeling tools will also allow us to explore neurotoxicity of PM composition and other gaseous pollutants (i.e. NO2, O3). Given the reconstructed exposure histories from gestation to childhood to early-adolescence, we will: (a) determine long-term cumulative exposure effects; and (b) examine differential exposure effects across sensitive time windows to better define PM2.5 neurotoxicity on executive functioning (EF) and emotional behaviors from ages 9 to 12 years-old (Aim 1); and also understand how the resulting neurotoxicity influences structural and functional brain development, including brain morphology, white matter microstructure, brain activity at rest and during EF and emotion-focused tasks, and functional connectivity of large-scale networks (Aim 2). In Aim 3, we will evaluate if children are more susceptible to PM2.5 effects based on: a) sex and SES; and b) family- and neighborhood-level contextual risk and protective factors. This application will advance our understanding of air pollution neurotoxicity on adolescent brains, as well as how exposure effects may vary across sensitive time windows of development and/or differ by individual susceptibility. The resulting new knowledge will contribute to sciences-based air pollution regulations to protect public health, but also inform the development of preventions and interventions targeting sensitive time-windows and vulnerable populations.

项目摘要 细微的物质（空气动力学直径<2.5μm; PM2.5）是一种新颖而无处不在的环境 神经毒素影响数百万居住在城市地区的数百万美国儿童的神经行为发展。 但是，我们的审查指出了较大的几个主要方法论上的局限性和关键知识差距 文献，包括：1）缺乏纵向大脑和行为评估的研究； 2）相对较小 来自局部地理区域的样品； 3）几乎没有有关长期累积和/或差异的信息 在整个发展中暴露的时机； 4）有关PM2.5神经毒性的剩余问题 在关键的神经行为过程中的暴露，在整个青少年中继续成熟。虽然动物 神经毒理学研究强调了性的重要性，只有有限的流行病学证据 儿童的PM2.5神经毒性的性别差异。此外，大脑发育也由家庭和 社区级的社会因素，但空气污染神经毒性是否与社会环境相互作用 仍然不清楚。该申请将利用全国范围的纵向 9岁和10岁儿童的开发（ABCD）研究（n = 11,873） 青少年脑认知 检查产前和儿童空气污染 美国21个城市男孩和女孩的神经行为发展的暴露影响。 ABCD结果 措施是基于早期青少年的过渡而锚定的，因为神经饱和继续 到成年初期的童年，使这种发展过渡期可能更容易受到影响 环境侮辱。我们的主要兴趣暴露是PM2.5，但验证时空的进步取得了进步 建模工具还将使我们能够探索PM组成和其他气态污染物的神经毒性（即 NO2，O3）。考虑到从妊娠到儿童期到早期早期的重建暴露历史，我们将： （a）确定长期累积暴露效应； （b）检查跨越差异的暴露效应 敏感的时间窗口更好地定义PM2.5执行功能（EF）和情感的神经毒性 9至12岁的行为（AIM 1）；并了解产生的神经毒性如何影响 结构和功能性脑发育，包括脑形态，白质微观结构，大脑 休息和以EF和以情感为中心的任务以及大规模网络的功能连接性的活动 （目标2）。在AIM 3中，我们将根据以下方式评估儿童是否更容易受到PM2.5效果的影响：a）性和SES； b）家庭和邻里水平的上下文风险和受保护因素。该应用程序将推动我们的 了解青少年大脑上空气污染神经毒性，以及暴露效应如何变化 在敏感的开发时间窗口中，/或通过个人敏感性不同。由此产生的新 知识将有助于基于科学的空气污染法规，以保护公共卫生，同时也告知 针对敏感的时间鸣叫和脆弱人群的预防和干预措施的发展。