The Role of Androgens in Amygdala Subnuclei Development Across Human Adolescence

雄激素在人类青春期杏仁核亚核发育中的作用

• 批准号: 9388088
• 负责人: Megan Marie Herting
• 金额: $ 9.69万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-18 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9388088
• 关键词: Address; Adolescence; Adolescent; Adult; Age; Amygdaloid structure; Androgen Receptor; Androgens; Animal Model; Animals; Behavior; Birds; Brain; CAG repeat; Castration; Cell Nucleus; Cereals; Childhood; Clinical; Complex; Data; Data Set; Databases; Development; Diffusion Magnetic Resonance Imaging; Expressed Sequence Tags; Female; Female Adolescents; Functional Magnetic Resonance Imaging; Funding; Future; Gene Expression Regulation; Genes; Genetic; Genetic Variation; Genotype; Goals; Growth; Health Sciences; Heterogeneity; Hormones; Human; Individual; Knowledge; Length; Life; Literature; Magnetic Resonance Imaging; Male Adolescents; Medial; Mediating; Methodology; Methods; Neurosciences; Neurosciences Research; Oregon; Pattern; Population; Process; Puberty; Reporting; Research; Research Personnel; Resolution; Role; Sampling; Sex Characteristics; Social Behavior; Structure; Techniques; Testosterone; Transactivation; Transcriptional Regulation; United States National Institutes of Health; Universities; base; boys; dimorphism; disorder risk; emotional behavior; girls; imaging genetics; improved; in vivo; interest; male; neurodevelopment; novel; receptor; receptor sensitivity; sex; sexual dimorphism; social

Abstract The human amy ygdala is a c in structure made up of a number of nuclei, which together are vital for complex brai an array of emo 18-23 otional and s viors that con evelop across adolescence. While a number social behav ntinue to de of structural MR ave examined sex differe mygdala maturation, these studies have reported RI studies ha ences in am mixed findings.12-17 Moreove tudies sugge cific and heterogeneous effects of testosterone er, animal st est sex-spec on the developm of var subnuclei within the amygdala.8-10 However, confirming similar patterns o ment rious r of growth in humans has been n limited by the inability ly segment amygdala subnuclei in adolescents y to precisel using MRI. Using a large NIH-funded im etic, and hormone adolescent dataset (N=450; ages 10-18 maging, gen yrs.; PI: Nagel), the current proposal aim ms to adapt a new in vivo amygdala segmentation approach to assess structural segme entation of amygdala s cross adolescence. Following individually based subnuclei subnuclei ac delineation, we a determine ho rone levels and androgen receptor (AR) sensitivity relates to also aim to d ow testoster neurotypic amy subn volum in adolescent oys and girls. Elucidating struc sexua ygdala nuclei mes bo g tural al dimorphisms in amygdala s humans ma ur understanding of amygdala development, as subnuclei in ay aid in ou well as ultimately help us to understan sex differences in various behaviors and risk for disease.7 nd life-long s Moreover, this r research wil ly contribute ger field of developmental neuroscience, as the ll significantl e to the larg current study ai date a meth process by which we can segment amygdala subnuclei in ims to elucid hodological p developing samp methods sh eful to a wide array of researchers who may wish to create ples. These hould be use specific normativ inical pediatr s for future structural, functional, and diffusion MRI studies. ve and/or cli ric templates

抽象的 人艾米 Ygdala是由许多核组成的结构的C，这对于 复杂的布莱 emo阵列18-23 卵形和跨青春期的卵形和viors。而一个数字 社会行为 这些研究报告 RI研究在AM中进行了加密 混合发现。12-17MoreVove tudies sugge cific和睾丸激素的异质作用 嗯，动物stest sex-spec 但是，在杏仁核内的var subnuclei的发育中 rious rious r 人类的增长已经 n受青少年的无能为力的杏仁核亚核的限制 y到precisel 使用MRI。使用大型NIH资助的IM ITET和激素青少年数据集（n = 450； 10-18岁 涂抹，gen 一年。 PI：Nagel），当前的建议目标 MS适应一种新的体内杏仁核细分方法来评估 结构segme 杏仁核的交叉青春期的探索。遵循单独的基核 亚核AC 描述，我们确定HO RONE水平和雄激素受体（AR）敏感性与 也旨在dow testoster 青春期牡蛎和女孩中的神经型Amy Subn体积。阐明struc sexua ygdala nuclei mes bo g tural al al 杏仁核的人类对杏仁核发展的理解， 在Ay ai援助的subnuclei 最终帮助我们理解各种行为和疾病风险的性别差异。7 ND终身 而且，这个r 研究将贡献GER的发育神经科学领域，作为 大量 当前的研究AI日期是甲基苯丙胺的过程 IMS到详尽的Hodological P 开发SAMP方法，向许多可能希望创建的研究人员 ples。这些应该使用 用于未来的结构，功能和扩散MRI研究的特定规范性养生。 VE和/或CLI RIC模板