The Role of Androgens in Amygdala Subnuclei Development Across Human Adolescence

雄激素在人类青春期杏仁核亚核发育中的作用

基本信息

批准号：
9388088
负责人：
Megan Marie Herting
金额：
$ 9.69万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-07-18 至 2019-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9388088
关键词：
Address Adolescence Adolescent Adult Age Amygdaloid structure Androgen Receptor Androgens Animal Model Animals Behavior Birds Brain CAG repeat Castration Cell Nucleus Cereals Childhood Clinical Complex Data Data Set Databases Development Diffusion Magnetic Resonance Imaging Expressed Sequence Tags Female Female Adolescents Functional Magnetic Resonance Imaging Funding Future Gene Expression Regulation Genes Genetic Genetic Variation Genotype Goals Growth Health Sciences Heterogeneity Hormones Human Individual Knowledge Length Life Literature Magnetic Resonance Imaging Male Adolescents Medial Mediating Methodology Methods Neurosciences Neurosciences Research Oregon Pattern Population Process Puberty Reporting Research Research Personnel Resolution Role Sampling Sex Characteristics Social Behavior Structure Techniques Testosterone Transactivation Transcriptional Regulation United States National Institutes of Health Universities base boys dimorphism disorder risk emotional behavior girls imaging genetics improved in vivo interest male neurodevelopment novel receptor receptor sensitivity sex sexual dimorphism social

Address Adolescence Adolescent Adult Age Amygdaloid structure Androgen Receptor Androgens Animal Model Animals Behavior Birds Brain CAG repeat Castration Cell Nucleus Cereals Childhood Clinical Complex Data Data Set Databases Development Diffusion Magnetic Resonance Imaging Expressed Sequence Tags Female Female Adolescents Functional Magnetic Resonance Imaging Funding Future Gene Expression Regulation Genes Genetic Genetic Variation Genotype Goals Growth Health Sciences Heterogeneity Hormones Human Individual Knowledge Length Life Literature Magnetic Resonance Imaging Male Adolescents Medial Mediating Methodology Methods Neurosciences Neurosciences Research Oregon Pattern Population Process Puberty Reporting Research Research Personnel Resolution Role Sampling Sex Characteristics Social Behavior Structure Techniques Testosterone Transactivation Transcriptional Regulation United States National Institutes of Health Universities base boys dimorphism disorder risk emotional behavior girls imaging genetics improved in vivo interest male neurodevelopment novel receptor receptor sensitivity sex sexual dimorphism social

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项目摘要

Abstract The human amy ygdala is a c in structure made up of a number of nuclei, which together are vital for complex brai an array of emo 18-23 otional and s viors that con evelop across adolescence. While a number social behav ntinue to de of structural MR ave examined sex differe mygdala maturation, these studies have reported RI studies ha ences in am mixed findings.12-17 Moreove tudies sugge cific and heterogeneous effects of testosterone er, animal st est sex-spec on the developm of var subnuclei within the amygdala.8-10 However, confirming similar patterns o ment rious r of growth in humans has been n limited by the inability ly segment amygdala subnuclei in adolescents y to precisel using MRI. Using a large NIH-funded im etic, and hormone adolescent dataset (N=450; ages 10-18 maging, gen yrs.; PI: Nagel), the current proposal aim ms to adapt a new in vivo amygdala segmentation approach to assess structural segme entation of amygdala s cross adolescence. Following individually based subnuclei subnuclei ac delineation, we a determine ho rone levels and androgen receptor (AR) sensitivity relates to also aim to d ow testoster neurotypic amy subn volum in adolescent oys and girls. Elucidating struc sexua ygdala nuclei mes bo g tural al dimorphisms in amygdala s humans ma ur understanding of amygdala development, as subnuclei in ay aid in ou well as ultimately help us to understan sex differences in various behaviors and risk for disease.7 nd life-long s Moreover, this r research wil ly contribute ger field of developmental neuroscience, as the ll significantl e to the larg current study ai date a meth process by which we can segment amygdala subnuclei in ims to elucid hodological p developing samp methods sh eful to a wide array of researchers who may wish to create ples. These hould be use specific normativ inical pediatr s for future structural, functional, and diffusion MRI studies. ve and/or cli ric templates

抽象的人艾米 Ygdala是由许多核组成的结构的C，这对于复杂的布莱 emo阵列18-23 卵形和跨青春期的卵形和viors。而一个数字社会行为这些研究报告 RI研究在AM中进行了加密混合发现。12-17MoreVove tudies sugge cific和睾丸激素的异质作用嗯，动物stest sex-spec 但是，在杏仁核内的var subnuclei的发育中 rious rious r 人类的增长已经 n受青少年的无能为力的杏仁核亚核的限制 y到precisel 使用MRI。使用大型NIH资助的IM ITET和激素青少年数据集（n = 450； 10-18岁涂抹，gen 一年。 PI：Nagel），当前的建议目标 MS适应一种新的体内杏仁核细分方法来评估结构segme 杏仁核的交叉青春期的探索。遵循单独的基核亚核AC 描述，我们确定HO RONE水平和雄激素受体（AR）敏感性与也旨在dow testoster 青春期牡蛎和女孩中的神经型Amy Subn体积。阐明struc sexua ygdala nuclei mes bo g tural al al 杏仁核的人类对杏仁核发展的理解，在Ay ai援助的subnuclei 最终帮助我们理解各种行为和疾病风险的性别差异。7 ND终身而且，这个r 研究将贡献GER的发育神经科学领域，作为大量当前的研究AI日期是甲基苯丙胺的过程 IMS到详尽的Hodological P 开发SAMP方法，向各种可能希望创建的研究人员 ples。这些应该使用用于未来的结构，功能和扩散MRI研究的特定规范性养生。 VE和/或CLI RIC模板