Supplemental Funding Request for RF1 AG062309 Early life glycemic status and Alzheimer's disease neuroimaging markers in middle age: the Bogalusa Heart Study

RF1 AG062309 的补充资金申请 早期血糖状态和中年阿尔茨海默病神经影像标记：Bogalusa 心脏研究

• 批准号: 10161514
• 负责人: Lydia Bazzano
• 金额: $ 31.01万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-15 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10161514
• 关键词: African American; Alzheimer' s Disease; Alzheimer' s disease risk; Area; Body Composition; Brain; COVID-19; Carbohydrates; Cardiac health; Clinical; Cognitive; Data; Data Collection; Development; Diet; Distal; Eating; Energy Intake; Epidemic; Equipment and supply inventories; Event; Exposure to; Fatty acid glycerol esters; Food; Frequencies; Funding; Future; Health; Heart; Home environment; Impaired cognition; Individual; Intake; International; Life; Life Style; Longevity; Longitudinal cohort study; Louisiana; Magnetic Resonance Imaging; Measurement; Measures; Memory; Metabolic; Outcome; Parents; Participant; Persons; Physical activity; Positioning Attribute; Positron-Emission Tomography; Proteins; Questionnaires; Reporting; Risk Factors; Rural; Sleep; Standardization; Structure; Surveys; Time; Visit; base; brain health; cardiometabolic risk; cardiometabolism; clinically significant; cognitive function; data quality; design; experience; fasting plasma glucose; high risk; instrument; lifestyle factors; lifestyle intervention; middle age; moderate-to-vigorous physical activity; neuroimaging marker; pandemic disease; research clinical testing; response; sleep quality; socioeconomics

The parent study (R01AG062309) examines associations between lifespan cardiometabolic exposures and midlife brain structure and function, as well as midlife cognitive function, in the bi-racial, semi-rural Bogalusa Heart Study (BHS). The importance of the main study is that it clarifies which cardiometabolic exposures influence the brain health of a socioeconomically diverse group of African American and white individuals at the portion of the lifespan (the 50s and early 60s) when cognitive and brain health begins to become more heterogeneous and begins to include clinically- significant cognitive decline in a large number of persons. This supplement adds three additional cardiometabolic exposures to the set of exposures we will examine: sudden reductions in physical activity, diet quality, and sleep quality caused by Covid-19 related home confinement. BHS participants will receive the same set of diet, physical activity, and sleep questionnaires that are assessed at each of their prior BHS study visits, along with a new survey specifically designed to identify Covid19-related changes. There is an extreme time urgency to assessing such confinement-related sudden lifestyle changes: BHS participants are confined to the home now, and are therefore able to assess their own confinement-related lifestyle changes now, rather than rely on error-prone recall of distal events. The supplement significantly enhances the parent study by providing data on exactly the sort of sudden, event-driven cardiometabolic changes that are important to long-term outcomes, but are typically missed by a longitudinal cohort study such as BHS, whose structure lends itself to measuring slowly-varying changes over the course of years. The supplement could clarify the importance of such sudden lifestyle changes to long-term health, relative to such slowly time-varying changes. In so doing, the supplement could clarify the importance of rapidly deploying lifestyle interventions to home-confined individuals to support high diet quality, physical activity attainment, and sleep quality in the event of a future pandemic.

母研究 (R01AG062309) 检查寿命之间的关联 心脏代谢暴露和中年大脑结构和功能，以及中年 认知功能，在双种族、半农村博加卢萨心脏研究 (BHS) 中。这 主要研究的重要性在于它阐明了哪些心脏代谢暴露 影响社会经济多元化的非裔美国人群体的大脑健康 白人在一生中的某个阶段（50 岁和 60 岁出头）认知能力 大脑健康开始变得更加异质化，并开始包括临床- 许多人的认知能力显着下降。本次补充增加了三项 我们将检查的一组暴露的额外心脏代谢暴露：突然 由 Covid-19 相关引起的体力活动、饮食质量和睡眠质量下降 居家禁闭。 BHS 参与者将接受相同的饮食、身体活动、 以及在之前每次 BHS 研究访视时评估的睡眠问卷，以及 一项专门旨在识别与新冠病毒相关的变化的新调查。有一个 评估这种与禁闭相关的突然生活方式改变的时间极其紧迫： BHS 参与者现在被限制在家里，因此能够评估他们的情况 现在就改变自己与坐月子相关的生活方式，而不是依赖于容易出错的回忆 远端事件。该补充品通过提供数据显着增强了家长研究 正是这种突然的、事件驱动的重要的心脏代谢变化 长期结果，但通常会被纵向队列研究遗漏，例如 BHS，其结构适合测量过程中缓慢变化的变化 年。该补充剂可以阐明这种生活方式突然改变的重要性 相对于这种随时间缓慢变化的变化而言，对长期健康的影响。这样做时， 补充品可以阐明快速部署生活方式干预措施的重要性 居家隔离的个人，以支持高饮食质量、身体活动的实现， 以及未来发生大流行时的睡眠质量。