A novel research infrastructure enabling life-course studies of healthy aging

新型研究基础设施可实现健康老龄化的生命历程研究

• 批准号: 9756284
• 负责人: Lydia Bazzano
• 金额: $ 23.11万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2020-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9756284
• 关键词: Adolescence; Adolescent; Adolescent and Young Adult; Adult; Affect; Aging; Alcohols; Area; Attention; Biometry; Blood; Blood Vessels; Cardiac; Cardiology; Cardiovascular system; Cataloging; Catalogs; Child; Childhood; Chronic; Chronic Disease; Clinic; Clinical; Cognition; Complement; Data; Data Collection; Data Files; Development; Diet; Dietary intake; Disease; Documentation; Electrocardiogram; Enrollment; Epidemiology; Event; Feces; Future; Genetic; Gerontology; Goals; Gold; Growth; Growth and Development function; Health; Health Status; Heart; Heart Rate; Home environment; Information Sciences; Internal Medicine; International; Interview; Investments; Lead; Life; Life Cycle Stages; Life Experience; Life Style; Lipids; Longevity; Longitudinal Studies; Louisiana; Maintenance; Measurement; Measures; Methods; National Heart, Lung, and Blood Institute; Neurology; Organ; Outcome; Oxygen; Pathway interactions; Pediatric Neurology; Pediatric cardiology; Persons; Phase; Physical Function; Physical Performance; Physical activity; Physiologic pulse; Physiological; Pilot Projects; Play; Population Heterogeneity; Positioning Attribute; Process; Quality of life; Questionnaires; Reproductive History; Research; Research Infrastructure; Research Personnel; Resources; Risk Factors; Role; Saliva; Science; Sleep; Social isolation; Social support; Specimen; Structure; System; Telephone Interviews; Testing; Tobacco use; United States National Institutes of Health; Vascular System; Visit; biobank; cardiometabolism; cognitive function; cohort; cost effective; critical period; disorder risk; epidemiology study; follow-up; functional independence; healthy aging; improved; infrastructure development; lifestyle factors; member; middle age; mobile computing; multidisciplinary; multiple chronic conditions; novel; prospective; protective factors; racial diversity; research study; sample collection; tool; user-friendly; virtual

Project Summary: There are critical periods in growth and development where “programming” of fixed future capacity takes place impacting long-term health. Early life factors may play a role in successful aging via the vascular system since subclinical changes in vascular structure and function occur early in the aging process, contributing to sub- clinical changes in cognition and physical functioning. Understanding the role of these early life factors in the maintenance of physical and cognitive function is of critical importance for identifying the ideal path to successful aging. The 3 studies included in this proposal (Bogalusa Heart Study [BHS, Louisiana], NHLBI Growth and Health Study [NGHS, Ohio], Princeton Lipid Research Study [PLRS, Ohio]) enrolled black and white children and adolescents who have continued follow for up for more than 40 years. Each cohort has had multiple sub-studies over the years and these valuable, under-utilized resources (data and bio-specimens) require infrastructure development to efficiently leverage NIH investment and advance aging sciences through the interdisciplinary use of life-course data, prospectively collected over more than 4 decades. Our long-term goal is to understand the childhood, adolescent, and young adult influences on the aging process. The overall objective of this proposal is to develop and enhance a novel research infrastructure that will advance the science of aging in the area of early life and childhood protective factors that contribute to “successful” aging. Specifically, in the R21 phase, we will catalog and consolidate biorepositories, create clear and detailed documentation for each cohort and build comprehensive harmonized data files across the 3 cohorts. These activities will uniquely position the cohorts to provide life-course assessments of pathways between childhood health and lifestyle factors and intermediate markers of target organ damage in the aging process. In the R33 phase, we will demonstrate the feasibility of remote measurement methods by conducting telephone interviews to assess chronic conditions, mobility, physical and cognitive function, social support and quality of life, and assess physical risk factor data using mailed sample collection kits for saliva and stool as well as mobile assessments of HR, ECG, BP, PWV, and oxygen saturation. Epidemiologic validity for future aging studies will be enhanced by testing methods for assessing aging-related outcomes with remote contact and mobile technologies, enabling the future participation of cohort members who have moved away from their childhood hometowns. The investigative team proposed is multidisciplinary, with expertise in pediatrics, cardiology, internal medicine, neurology, epidemiology and biostatistics. Ultimately, this application proposes to enhance a unique scientific resource that will facilitate valid life-course approaches to define the ideal path to successful aging, leveraging decades of NIH investment.

项目概要： 在成长和发展的关键时期，会发生对未来固定能力的“规划” 影响长期健康的早期生命因素可能通过血管系统在成功衰老中发挥作用。 血管结构和功能的亚临床变化发生在衰老过程的早期，导致亚临床症状。 了解这些早期生命因素在认知和身体功能方面的临床变化。 维持身体和认知功能对于确定实现目标的理想途径至关重要 该提案中包含的 3 项研究（Bogalusa 心脏研究 [BHS，路易斯安那州]、NHLBI） 生长与健康研究 [NGHS，俄亥俄州]、普林斯顿脂质研究 [PLRS，俄亥俄州]）招募了黑人和 持续追踪了 40 多年的白人儿童和青少年。 多年来的多项子研究以及这些宝贵的、未充分利用的资源（数据和生物样本） 需要基础设施发展以有效利用 NIH 投资并通过以下方式推进老龄化科学 对生命历程数据的跨学科使用，这些数据是我们 4 多年长期前瞻性收集的。 目标是了解童年、青少年和年轻人对衰老过程的影响。 该提案的目标是开发和加强新型研究基础设施，以促进 有助于“成功”衰老的早期生命和儿童保护因素领域的衰老科学。 具体来说，在R21阶段，我们将对生物样本库进行编目和整合，创建清晰详细的生物样本库。 每个队列的文档，并跨 3 个队列建立全面的统一数据文件。 活动将使这些群体处于独特的地位，以提供童年时期之间路径的生命历程评估 R33 中的健康和生活方式因素以及靶器官损伤的中间标志。 阶段，我们将通过电话访谈的方式论证远程测量方法的可行性 评估慢性病、活动能力、身体和认知功能、社会支持和生活质量，以及 使用邮寄的唾液和粪便样本采集套件以及移动样本评估身体风险因素数据 评估心率、心电图、血压、脉搏波速度和血氧饱和度对未来老龄化研究的有效性。 通过远程接触和移动评估衰老相关结果的测试方法将得到增强 技术，使脱离童年的群体成员能够参与未来 拟议的调查小组是多学科的，具有儿科、心脏病学、 最终，该应用旨在增强内科、神经病学、流行病学和生物统计学的能力。 独特的科学资源，将促进有效的生命历程方法，以确定成功的理想道路 老龄化，利用美国国立卫生研究院数十年的投资。