A novel research infrastructure enabling life-course studies of healthy aging

新型研究基础设施可实现健康老龄化的生命历程研究

• 批准号: 9756284
• 负责人: Lydia Bazzano
• 金额: $ 23.11万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2020-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9756284
• 关键词: Adolescence; Adolescent; Adolescent and Young Adult; Adult; Affect; Aging; Alcohols; Area; Attention; Biometry; Blood; Blood Vessels; Cardiac; Cardiology; Cardiovascular system; Cataloging; Catalogs; Child; Childhood; Chronic; Chronic Disease; Clinic; Clinical; Cognition; Complement; Data; Data Collection; Data Files; Development; Diet; Dietary intake; Disease; Documentation; Electrocardiogram; Enrollment; Epidemiology; Event; Feces; Future; Genetic; Gerontology; Goals; Gold; Growth; Growth and Development function; Health; Health Status; Heart; Heart Rate; Home environment; Information Sciences; Internal Medicine; International; Interview; Investments; Lead; Life; Life Cycle Stages; Life Experience; Life Style; Lipids; Longevity; Longitudinal Studies; Louisiana; Maintenance; Measurement; Measures; Methods; National Heart, Lung, and Blood Institute; Neurology; Organ; Outcome; Oxygen; Pathway interactions; Pediatric Neurology; Pediatric cardiology; Persons; Phase; Physical Function; Physical Performance; Physical activity; Physiologic pulse; Physiological; Pilot Projects; Play; Population Heterogeneity; Positioning Attribute; Process; Quality of life; Questionnaires; Reproductive History; Research; Research Infrastructure; Research Personnel; Resources; Risk Factors; Role; Saliva; Science; Sleep; Social isolation; Social support; Specimen; Structure; System; Telephone Interviews; Testing; Tobacco use; United States National Institutes of Health; Vascular System; Visit; biobank; cardiometabolism; cognitive function; cohort; cost effective; critical period; disorder risk; epidemiology study; follow-up; functional independence; healthy aging; improved; infrastructure development; lifestyle factors; member; middle age; mobile computing; multidisciplinary; multiple chronic conditions; novel; prospective; protective factors; racial diversity; research study; sample collection; tool; user-friendly; virtual

Project Summary: There are critical periods in growth and development where “programming” of fixed future capacity takes place impacting long-term health. Early life factors may play a role in successful aging via the vascular system since subclinical changes in vascular structure and function occur early in the aging process, contributing to sub- clinical changes in cognition and physical functioning. Understanding the role of these early life factors in the maintenance of physical and cognitive function is of critical importance for identifying the ideal path to successful aging. The 3 studies included in this proposal (Bogalusa Heart Study [BHS, Louisiana], NHLBI Growth and Health Study [NGHS, Ohio], Princeton Lipid Research Study [PLRS, Ohio]) enrolled black and white children and adolescents who have continued follow for up for more than 40 years. Each cohort has had multiple sub-studies over the years and these valuable, under-utilized resources (data and bio-specimens) require infrastructure development to efficiently leverage NIH investment and advance aging sciences through the interdisciplinary use of life-course data, prospectively collected over more than 4 decades. Our long-term goal is to understand the childhood, adolescent, and young adult influences on the aging process. The overall objective of this proposal is to develop and enhance a novel research infrastructure that will advance the science of aging in the area of early life and childhood protective factors that contribute to “successful” aging. Specifically, in the R21 phase, we will catalog and consolidate biorepositories, create clear and detailed documentation for each cohort and build comprehensive harmonized data files across the 3 cohorts. These activities will uniquely position the cohorts to provide life-course assessments of pathways between childhood health and lifestyle factors and intermediate markers of target organ damage in the aging process. In the R33 phase, we will demonstrate the feasibility of remote measurement methods by conducting telephone interviews to assess chronic conditions, mobility, physical and cognitive function, social support and quality of life, and assess physical risk factor data using mailed sample collection kits for saliva and stool as well as mobile assessments of HR, ECG, BP, PWV, and oxygen saturation. Epidemiologic validity for future aging studies will be enhanced by testing methods for assessing aging-related outcomes with remote contact and mobile technologies, enabling the future participation of cohort members who have moved away from their childhood hometowns. The investigative team proposed is multidisciplinary, with expertise in pediatrics, cardiology, internal medicine, neurology, epidemiology and biostatistics. Ultimately, this application proposes to enhance a unique scientific resource that will facilitate valid life-course approaches to define the ideal path to successful aging, leveraging decades of NIH investment.

项目摘要： 在增长和发展中有关键时期，固定未来能力的“编程”发生 影响长期健康。早期生活因素可能在通过血管系统成功衰老中起作用，因为 血管结构和功能的亚临床变化发生在衰老过程的早期，有助于亚 认知和身体功能的临床变化。了解这些早期生活因素在 维持身体和认知功能对于确定理想的途径至关重要 成功的衰老。该提案中包括的3项研究（Bogalusa心脏研究[BHS，路易斯安那州]，NHLBI 增长与健康研究[NGHS，俄亥俄州]，普林斯顿脂质研究研究[PLRS，俄亥俄州]） 继续跟进的白人儿童和青少年已有40多年的历史。每个队列都有 多年来多种子研究以及这些有价值的，未充分利用的资源（数据和生物规范） 需要基础设施开发以有效利用NIH投资并通过 生命过程数据的跨学科使用可能在超过40年中收集。我们的长期 目标是了解童年，青少年和年轻人对衰老过程的影响。总体 该提案的目的是开发和增强新的研究基础设施，该基础设施将推动 早期生活和儿童期受到衰老的科学受到“成功”衰老的保护因素。 具体而言，在R21阶段，我们将分类和巩固生物座席，创建清晰而详细的 每个队列的文档，并在3个队列中构建全面的协调数据文件。这些 活动将独特地定位同类人群以提供童年之间的道路评估 衰老过程中目标器官损害的健康和生活方式因素和中间标记。在R33中 阶段，我们将通过进行电话访谈来证明远程测量方法的可行性 评估慢性病，流动性，身体和认知功能，社会支持和生活质量以及 使用邮寄的样品收集套件评估唾液和粪便以及手机的物理风险因素数据 评估人力资源，ECG，BP，PWV和氧气安全。未来衰老研究的流行病学有效性 通过测试方法来评估远程联系和移动的测试方法，可以增强 技术，使远离童年的队列成员的未来参与 家乡。提出的调查团队是多学科的，具有儿科，心脏病学专业知识， 内科，神经病学，流行病学和生物统计学。最终，该申请提出了增强的建议 独特的科学资源将有助于有效的生活方式方法来定义成功的理想途径 老化，利用数十年的NIH投资。