I3C DECADE: Disparities and Equity in Childhood Cardiovascular Exposures and Alzheimer's Dementia

I3C 十年：儿童心血管暴露和阿尔茨海默氏痴呆的差异和公平

• 批准号: 10653088
• 负责人: Lydia Bazzano
• 金额: $ 305.12万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10653088
• 关键词: Acceleration; Address; Affect; Age; Alzheimer' s Disease; Alzheimer' s disease pathology; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Biological Markers; Black Populations; Blood; Blood Pressure; Blood Vessels; Cardiovascular system; Child; Childhood; Clinical; Clinical Practice Guideline; Cognitive; Cohort Studies; Collaborations; Data; Data Set; Development; Disadvantaged; Disparity; Education; Elderly; Equity; Ethnic Population; Event; Exposure to; Factor Analysis; Generations; Geography; Glucose; Green space; Growth; Health; Heart; Impaired cognition; Individual; Indole-3-Carbinol; International; Investments; Joints; Knowledge; Life; Life Cycle Stages; Lipids; Longitudinal Studies; Measures; Metabolic; National Heart, Lung, and Blood Institute; National Institute on Aging; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Participant; Population; Postmenopause; Premenopause; Prevalence; Prevention; Process; Recording of previous events; Reproducibility; Research; Risk Factors; Sampling; Time; United States National Institutes of Health; Vascular System; Weather; Woman; Work; Youth; blood-based biomarker; boys; brain health; cardiovascular health; cardiovascular risk factor; clinical development; cognitive performance; cognitive testing; cohort; critical period; data harmonization; data resource; dementia risk; disease disparity; effective therapy; follow-up; food security; geographic disparity; girls; health data; health disparity; in utero; indexing; men; middle age; novel; open data; pollutant; population based; progression risk; prospective; public health relevance; racial disparity; racial population; research study; sex; socioeconomic disadvantage; socioeconomics

SUMMARY Risk for Alzheimer’s Disease and related dementias (ADRD) remains higher in black populations than in other race/ethnic groups.This may be due at least in part to accumulated disadvantage which accelerates the progression of cardiovascular (CV) risk factors, that in turn may contribute to the development of clinically silent Alzheimer’s pathology as early as middle age. Our team has demonstrated that exposure to CV risk factors such as obesity, elevated glucose, lipids and blood pressure can impact the vascular system by childhood and even in utero. Early vascular changes, in turn, may contribute to changes in brain health decades later. Despite documented socioeconomic and geographic disadvantages more often encountered by blacks (in, e.g., food security, green spaces, education quality, pollutants) that promote CV health disparities in childhood, there is little data examining such influences on Alzheimer’s related brain health in midlife or later. This is primarily due to limited prospectively collected, life-course data on blacks. Addressing this knowledge gap is increasingly urgent, as many more black and white children will develop adverse CV profiles now as compared to previous generations. We propose to leverage the significant NIH investment in prospectively collected data, from black and white men and women participating in the Bogalusa Heart Study (BHS), NHLBI Growth and Health Study (NGHS), and Princeton Lipid Research Study (PLRS). These unique life course studies have a strong history of collaboration and data harmonization formalized since 2009 through the international childhood CV cohort consortium (I3C), with joint follow-up of CV events since 2015. Shared exposure data include geographic, socioeconomic, and CV risk factors in childhood (from ages 3-19 years), with 40+ years of follow-up. Measuring brain health indicators in these cohorts will allow, for the first time, exploration of the impact of early life CV health disparities and antecedent disadvantages on midlife brain health in blacks and whites. In the proposed study, Disparities and Equity in Childhood CV Exposure and Alzheimer’s DEmentia (I3C DECADE), we will collect structural, functional, cognitive and blood-based indicators of ADRD-related brain health processes in mid-life (40-55 years), a period when the subtle impacts of subclinical vascular changes on brain health first begin to emerge, often several decades before ADRD become clinically evident. The PIs of these cohort studies will leverage their ongoing collaboration to build and share a novel data resource that advances open science in early life risk factors, and extends that effort to ADRD. The impact of this work will be to inform strategies that may reduce ADRD health disparities by identifying and intervening among black and white boys and girls whose CV burden places them at increased risk of ADRD decades later and has the potential to lead to changes in pediatric clinical practice guidelines. The proposed I3C DECADE Study represents a unique, and arguably the only opportunity to investigate the influence of childhood CV risk and disparities on ADRD-related brain health in the critical period of midlife.

概括 黑人人群中阿尔茨海默氏病和相关痴呆症（ADRD）的风险仍然高于其他 种族/族裔群体。这可能至少部分是由于加速加速的灾难 心血管（CV）风险因素的进展，这可能有助于临床上的发展 寂静的阿尔茨海默氏症早在中年的病理。我们的团队证明了暴露于简历风险 肥胖，葡萄糖，脂质和血压等因素可能会影响血管系统 童年，甚至在子宫里。反过来，早期的血管变化可能导致大脑健康的变化 几十年后。尽管有记载的社会经济和地理灾难经常遇到 黑人（例如，粮食安全，绿色空间，教育质量，污染物），促进简历健康分布 在童年时期，几乎没有数据检查对中年或中年相关的大脑健康的这种影响 之后。这主要是由于前瞻性收集的黑人生命数据数据所致。解决这个问题 知识差距越来越紧迫，因为更多的黑白儿童将发展不良的简历概况 现在与前几代相比。我们建议利用大量的NIH投资 前瞻性收集的数据，来自参加Bogalusa心脏研究的黑白男女 （BHS），NHLBI增长与健康研究（NGHS）和普林斯顿脂质研究（PLRS）。这些独特 生活课程研究具有自2009年以来正式化正式合作和数据协调的悠久历史 自2015年以来，国际童年CV队列联盟（I3C）进行了简历活动的联合随访。 共享的暴露数据包括儿童期地理，社会经济和简历风险因素（从3-19岁开始 年），随访40多年。测量这些队列中的大脑健康指标将允许第一个 时间，探索早期生命的影响CV健康差异和前期灾难对中年大脑的影响 黑人和白人的健康。在拟议的研究中，儿童期CV暴露的差异和公平性和 阿尔茨海默氏症的痴呆症（I3C十年），我们将收集结构，功能，认知和基于血液 中期（40 - 55年）的ADRD相关大脑健康过程的指标，这是微妙影响的时期 大脑健康的亚临床血管变化首先开始出现，通常是在ADRD之前的几十年 成为临床证据。这些队列研究的PI将利用其持续的合作来建立和 分享一种新颖的数据资源，该数据资源在早期生活风险因素中推动了开放科学，并将这种努力扩展到 adrd。这项工作的影响将是告知可能减少ADRD健康分配的策略 识别和干预黑人和白人男孩和女孩的简历燃烧使他们增加了 几十年后，ADRD的风险有可能导致小儿临床实践指南的变化。 拟议的I3C十年研究代表了一个独特的，可以说是调查调查的唯一机会 儿童期CV风险和差异对中年关键时期与ADRD相关的大脑健康的影响。