Synthetic Antibody Mimics as Antimalarial Agents

作为抗疟剂的合成抗体模拟物

• 批准号: 10161881
• 负责人: Mark Patrick Farrell
• 金额: $ 13.43万
• 依托单位: UNIVERSITY OF KANSAS LAWRENCE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10161881
• 关键词: Address; Administrator; Animals; Antimalarials; Area; Biological; Biological Models; Biological Sciences; Biology; Biomedical Research; Centers of Research Excellence; Chemicals; Chemotherapy-Oncologic Procedure; Communicable Diseases; Communities; Core Facility; Development; Environment; Facility Accesses; Faculty; Funding; Future; Infectious Agent; Infectious Diseases Research; Infrastructure; Institution; Intervention; Kansas; Lead; Mentors; Mentorship; Microbiology; Modernization; Molecular; Organism; Pathogenesis; Pathway interactions; Peer Review; Pharmaceutical Chemistry; Pharmacologic Substance; Pharmacology; Principal Investigator; Process; Proteomics; Public Health; Research; Research Personnel; Resistance; Resources; Science; Scientist; Series; Techniques; United States National Institutes of Health; Universities; Validation; Virulence Factors; Work; antimicrobial; distinguished professor; drug discovery; effective therapy; experience; high throughput screening; human microbiota; infectious disease treatment; interest; microbial; mid-career faculty; multidisciplinary; novel; pathogen; professor; programs; public health relevance; recruit; synthetic antibodies; tool

DESCRIPTION (provided by applicant): The development of new treatments of infectious disease is a preeminent challenge of biomedical science due to the continued expansion of organisms resistant to existing therapies, the reemergence of infectious agents once thought vanquished, and the spread of infectious diseases lacking effective treatments. The present proposal seeks to establish a Center for Biomedical Research Excellence with a multidisciplinary theme of Chemical Biology of Infectious Disease. Chemical biology entails the discovery of chemical entities able to modulate pathways related to infectious processes and can lead to the identification of novel targets for chemical intervention. The proposed Center will strengthen infrastructure and enable scientists and biomedical research in the State of Kansas and be led by University Distinguished Professor Jeffrey Aube, an experienced researcher and scientific administrator. It will address the following specific aims: (1) Provide a world-class environment, appropriately administered and staffed, to provide researchers access to key techniques relevant to the chemical biology of infectious disease. (2) Support and enable junior faculty to build successful research programs through active mentorship, access to appropriate resources, and funding of meritorious programs. (3) Enhance infectious disease research throughout the regional scientific community by the recruitment of outstanding junior faculty, establishment of seminar series and other opportunities for scientific enrichment, and by providing core facility access to all interested researchers.

描述（由申请人提供）：由于有生物体对现有疗法具有抵抗力的生物体的持续扩展，感染力的再生能力曾经被认为消失，以及缺乏有效治疗的感染性疾病的传播，传染病科学的新疗法的发展是生物医学科学的巨大挑战。本提案旨在建立一个卓越生物医学研究中心，具有传染病化学生物学的多学科主题。化学生物学需要发现能够调节与传染过程相关的途径的化学实体，并可能导致鉴定新的化学干预靶标。拟议的中心将 加强堪萨斯州的基础设施并使科学家和生物医学研究，并由大学杰出教授杰弗里·奥布（Jeffrey Aube）领导，他是经验丰富的研究人员和科学管理员。它将解决以下具体目标：（1）提供适当管理和人员配备的世界一流环境，以使研究人员获得与传染病化学生物学相关的关键技术。 （2）支持并使初级教师能够通过积极的指导，获得适当的资源以及对功绩计划的资助来建立成功的研究计划。 （3）通过招募杰出的初级教师，建立研讨会系列和其他科学丰富的机会，并通过向所有感兴趣的研究人员提供核心设施，从而增强了整个区域科学界的传染病研究。