Operations Core

运营核心

• 批准号: 10793943
• 负责人: William Paul Duprex
• 金额: $ 98.46万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-18 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10793943
• 关键词: Acceleration; Address; Adherence; Administrator; Animals; Biological; Biology; Bioterrorism; Businesses; Certification; Collaborations; Complex; Creativeness; Decontamination; Development; Discipline; Effectiveness; Emergency Situation; Emerging Communicable Diseases; Engineering; Ensure; Environmental Health; Event; Evolution; Goals; Human Resources; Infection; Information Technology; Infrastructure; International; Intervention; Laboratories; Laboratory Animals; Logistics; Maintenance; Mission; Modeling; Modernization; Monitor; National Institute of Allergy and Infectious Disease; Pathogenesis; Regulation; Research; Research Activity; Rest; Running; Safety; Scientist; Secure; Security; Services; Structure; System; Time; Toxin; Universities; Vaccine Research; Veterinarians; Viral; Vision; Work; animal resource; arm; biodefense; biosafety level 3 facility; biosecurity; cohort; cost; emerging pathogen; high standard; improved; medical countermeasure; member; novel; operation; pandemic disease; pandemic preparedness; pathogen; preclinical development; pressure; programs; quality assurance; repaired; research facility; response; transmission process

OPERATIONS CORE ABSTRACT: The Regional Biocontainment Laboratory (RBL) within the Center for Vaccine Research (CVR) at the University of Pittsburgh is the biosafety level-3 (BSL-3) hub for infection biology. The mission of the RBL is threefold, to work on pathogen emergence, evolution and host-to-host transmission, to study the pathogenesis of emerging infectious diseases and to accelerate pre-clinical development of novel interventions and medical countermeasures for pandemic preparedness and biodefense. Our vision is to be a globally recognized, highly- collaborative, creative and forward-facing team of infection biologists who are poised to respond to emerging biological threats both at the national and international level. The entire facility is registered with the Division of Select Agents and Toxins (DSAT). It brings together infection biologists and clinicians from a variety of disciplines who require BSL-3 and animal (A)BSL-3 facilities for their wide ranging viral and bacterial research programs. The Operations Core will be responsible for the formal operationalization and development of our existing structures. These have evolved from the time the RBL was established, and although they have served their purpose, require modernization to ensure they will remain current and operationally fit-for-purpose. Biocontainment work is operationally complex, infrastructure-dense, and comprehensively regulated. Running BSL-3 laboratories safely, securely and successfully demands having a well-organized and highly integrated team of administrators, scientists, biosafety/biosecurity professionals, engineers/facilities staff and veterinarians/zootechnical staff. This is especially important in multi-pathogen, multi-user research facilities that study standard and select agent BSL-3 pathogens. The Operations Core will provide overall management and budgetary responsibility for the RBL. It will administer the daily, weekly, monthly and yearly BSL-3 activities essential for the support and services arms of the RBL to function. This will ensure that the BSL-3 laboratories are run and maintained at the highest standards and they are safe and secure. Operational support for the RBL in Pittsburgh will ensure we are ready to support any national response to a range of emerging infectious diseases in the event of another pandemic or bioterrorism attack. Supporting this cohort of BSL-3 scientists, who can pivot to work on new pathogens in an emergency, is certain to pay dividends.

操作核心 抽象的： 大学疫苗研究中心（CVR）内的区域生物内在实验室（RBL） 匹兹堡的属于感染生物学的生物安全3级（BSL-3）中心。 RBL的任务是三倍， 在病原体出现，进化和宿主传播方面的工作，以研究 新兴的传染病，并加速新的干预措施和医学的临床前发展 大流行准备和生物陷入困境的对策。我们的愿景是成为全球认可的，高度的 - 准备回应新兴的感染生物学家的合作，创造性和正面的感染生物学家团队 国家和国际层面都有生物威胁。整个设施已在部门注册 选择剂和毒素（DSAT）。它汇集了来自各种学科的感染生物学家和临床医生 他们需要BSL-3和动物（A）BSL-3设施来进行广泛的病毒和细菌研究计划。 操作核心将负责我们现有的正式操作和发展 结构。这些从建立RBL开始就发展起来了，尽管它们已经为他们服务 目的，需要现代化以确保它们将保持最新且在操作上拟合使用。 生物内在的工作在操作上是复杂的，基础设施密集的，并且经过全面调节。跑步 BSL-3实验室安全，安全，成功地要求拥有良好的整合 管理员，科学家，生物安全/生物安全专业人员，工程师/设施人员以及 兽医/Zootechnical员工。这在多病原，多用户研究设施中尤其重要 研究标准和选择剂BSL-3病原体。操作核心将提供总体管理和 RBL的预算责任。它将管理每日，每周，每月和每年的BSL-3活动 RBL功能的支持和服务武器至关重要。这将确保BSL-3实验室 以最高标准运行和维护，并且安全安全。 RBL的运营支持 在匹兹堡 如果发生另一次大流行或生物恐怖袭击，疾病。支持这一BSL-3科学家的同类 可以在紧急情况下旋转从事新病原体的工作，这肯定会带来股息。