Practices Core

实践核心

基本信息

批准号：
10793944
负责人：
William Paul Duprex
金额：
$ 72.71万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-18 至 2028-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10793944
关键词：
Acceleration Accountability Administrator Animals Biological Biology Bioterrorism Certification Complex Creativeness Discipline Elements Emergency Situation Emerging Communicable Diseases Engineering Ensure Environmental Health Equipment and supply inventories Event Evolution Goals Human Resources In Vitro Industry Infection Infrastructure International Intervention Laboratories Laboratory Animals Laboratory Assistant Lead Mentors Mission Monitor National Institute of Allergy and Infectious Disease Outcome Pathogenesis Procedures Reference Standards Regulation Reporting Reproducibility Research Research Personnel Rest Running Safety Scientist Secure Services Side Standardization Supervision System Toxin Training Tube Universities Vaccine Research Veterinarians Viral Vision Work animal resource biodefense biosafety level 3 facility biosecurity cohort data integrity data quality data quality/integrity emerging pathogen equipment training hands on instruction in vivo medical countermeasure member novel operation pandemic disease pandemic preparedness pathogen preclinical development programs quality assurance research facility response transmission process

Acceleration Accountability Administrator Animals Biological Biology Bioterrorism Certification Complex Creativeness Discipline Elements Emergency Situation Emerging Communicable Diseases Engineering Ensure Environmental Health Equipment and supply inventories Event Evolution Goals Human Resources In Vitro Industry Infection Infrastructure International Intervention Laboratories Laboratory Animals Laboratory Assistant Lead Mentors Mission Monitor National Institute of Allergy and Infectious Disease Outcome Pathogenesis Procedures Reference Standards Regulation Reporting Reproducibility Research Research Personnel Rest Running Safety Scientist Secure Services Side Standardization Supervision System Toxin Training Tube Universities Vaccine Research Veterinarians Viral Vision Work animal resource biodefense biosafety level 3 facility biosecurity cohort data integrity data quality data quality/integrity emerging pathogen equipment training hands on instruction in vivo medical countermeasure member novel operation pandemic disease pandemic preparedness pathogen preclinical development programs quality assurance research facility response transmission process

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项目摘要

PRACTICES CORE ABSTRACT: The Regional Biocontainment Laboratory (RBL) within the Center for Vaccine Research (CVR) at the University of Pittsburgh is the biosafety level-3 (BSL-3) hub for infection biology. The mission of the RBL is threefold, to work on pathogen emergence, evolution and host-to-host transmission, to study the pathogenesis of emerging infectious diseases and to accelerate pre-clinical development of novel interventions and medical countermeasures for pandemic preparedness and biodefense. Our vision is to be a globally recognized, highly- collaborative, creative and forward-facing team of infection biologists who are poised to respond to emerging biological threats both at the national and international level. The entire facility is registered with the Division of Select Agents and Toxins (DSAT). It brings together infection biologists and clinicians from a variety of disciplines who require BSL-3 and animal (A)BSL-3 facilities for their wide ranging viral and bacterial research programs. Biocontainment work is operationally complex, infrastructure-dense, and comprehensively regulated. Running BSL-3 laboratories safely, securely and successfully demands having a well-organized and highly integrated team of administrators, scientists, biosafety/biosecurity professionals, engineers/facilities staff and veterinarians/zootechnical staff. This is especially important in multi-pathogen, multi-user research facilities that study standard and select agent BSL-3 pathogens. The Practices Core will support all the basic functions of the RBL enabling scientific programs to be rigorously managed and ensuring overall data integrity for reproducible outcomes. It will provide the requisite theoretical and practical trainings to onboard new RBL Investigators and their teams who wish to work in BSL-3 and ABSL-3 biocontainment. It will provide biosafety and biosecurity support and guarantee the facility meets all current compliance regulations for Tier 1 select agent registered laboratories. Provision of technical and support for the RBL in Pittsburgh will ensure we are ready to respond to any national response to a range of emerging infectious diseases in the event of another pandemic or bioterrorism attack. Supporting this cohort of BSL-3 scientists, who can pivot to work on new pathogens in an emergency, is certain to pay dividends.

实践核心抽象的：大学疫苗研究中心（CVR）内的区域生物内在实验室（RBL）匹兹堡的属于感染生物学的生物安全3级（BSL-3）中心。 RBL的任务是三倍，在病原体出现，进化和宿主传播方面的工作，以研究新兴的传染病，并加速新的干预措施和医学的临床前发展大流行准备和生物陷入困境的对策。我们的愿景是成为全球认可的，高度的 - 准备回应新兴的感染生物学家的合作，创造性和正面的感染生物学家团队国家和国际层面都有生物威胁。整个设施已在部门注册选择剂和毒素（DSAT）。它汇集了来自各种学科的感染生物学家和临床医生他们需要BSL-3和动物（A）BSL-3设施来进行广泛的病毒和细菌研究计划。生物内在的工作在操作上是复杂的，基础设施密集的，并且经过全面调节。跑步 BSL-3实验室安全，安全，成功地要求拥有良好的整合且高度整合管理员，科学家，生物安全/生物安全专业人员，工程师/设施人员以及兽医/Zootechnical员工。这在多病原，多用户研究设施中尤其重要研究标准和选择剂BSL-3病原体。实践核心将支持 RBL使科学计划得到严格管理并确保可重复的总体数据完整性结果。它将为新的RBL调查人员提供必要的理论和实用培训希望在BSL-3和ABSL-3生物内生化的团队。它将提供生物安全和生物安全性支持和保证该设施符合第1层的所有当前合规性法规注册实验室。在匹兹堡为RBL提供技术和支持，将确保我们准备回应在另一个大流行或生物恐怖主义攻击。支持这一BSL-3科学家，他们可以枢转工作紧急情况，肯定会偿还股息。