ELECTRON MICROSCOPIC STUDY ON ORAL LESIONS OF HIV-INFECTION

HIV 感染口腔病变的电子显微镜研究

• 批准号: 09672058
• 负责人: SUGIHARA Kazumasa
• 金额: $ 1.79万
• 依托单位: KAGOSHIMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09672058/
• 关键词: HUMAN IMMUNODEFICIENCY VIRUS; ORAL LESIONS; ELECTRON MICROSCOPY; HIV-ASSOCIATED PERIODONTAL DISEASE; ヒト免疫不全ウィルス(HIV); 口腔カンジタ症; HIV歯周疾患; ヒト免疫不全ウイルス(HIV); 口腔カンジダ症

ORAL LESIONS STRONGLY ASSOCIATED WITH HIV INFECTION ARE ORAL CANDIDIASIS, ORAL HAIRY LEUKOPLAKIA, INTRAORAL KAPOSI'S SARCOMA, NON-HODGKIN LYMPHOMA AND HIV-ASSOCIATED PERIODONTAL DISEASE.WE INVESTIGATED ULTRASTRUCTURAL FINDINGS OF THE GINGIVA DIAGNOSED PERIODONTITIS AND ACUTE NECROTIZING ULCERATIVE GINGIVITIS IN HIV-INFECTED PATIENTS. IN THE TISSUE SUFFERED FROM PERIODONTITIS, EPITHELIAL CELLS WERE EDEMATOUS. NEITHER VIRAL PARTICLES NOR VIRAL BUDDINGS WERE INDENTIFIED. HOWEVER THERE WERE TWO CHARACTERISTIC FINDINGS. AT FIRST, TUBULO-RETICULAR STRUCTURES WERE FREQUENTLY FOUND IN THE ENDOTHELIAL CELLS OF THE CAPILLARIES IN THE SUBEPITHELIAL LAYER. NEXT MULTIPLE EXTRAVASATED ERYTHROCYTES WERE ALSO OBSERVED. IN THE TISSUE SUFFRED FROM ACUTE NECROTIZING ULCERATIVE GINGIVITIS, MANY SPIROCHETAS WERE OBSERVED. THESE FINDINGS CONCERNING TWO TYPE OF PERIODONTAL DISEASE SUGGESTED THE MORPHOLOGICAL EXPRESSION IN THE GINGIVA ASSOCIATED WITH HIV-INFECTED PATIENTS.

与HIV感染密切相关的口腔病变是口腔念珠菌病，口腔毛状白细胞，口腔内Kaposi的肉瘤，非霍奇金淋巴瘤和HIV相关的牙周病。在患有牙周炎的组织中，上皮细胞是水肿的。病毒颗粒和病毒芽均未缩进。但是有两个特征性的发现。首先，在上皮下层的毛细血管内皮细胞中经常发现微管鼠结构。还观察到了下一个多个外部外部红细胞。在急性坏死性溃疡性牙龈炎的组织中，观察到许多螺旋杆菌。这些关于两种类型牙周疾病的发现表明与感染HIV感染患者有关的牙龈的形态表达。

项目成果

KAZUMASA SUGIHARA: "ORAL MANIFESTATIONS OF HIV-INFECTED PATIENTS-CLINICAL FEATURES AND ITS ELECTRON MICROSCOPIC FINDINGS"THE ANNALS OF KAGOSHIMA UNIVERSITY DENTAL SCHOOL. 18. 31-40 (1998)

Kazumasa Sugihara：“HIV 感染患者的口腔表现 - 临床特征及其电子显微镜检查结果”鹿儿岛大学牙科学院年鉴。

KENJI HASHIMOTO: "Electron Microscopic Atlas of Oral Disease" Nagasue Shoten, 173 (1998)

桥本贤治：《口腔疾病电子显微镜图谱》长末书店，173（1998）

TETSURO ISHIGAMI, KAZUMASA SUGIHARA, P.A.REICHART: "ULTRASTRUCTURAL STUDY ON THE PERIODONTAL DISEASE OF HIV-INFECTED PATIENTS"JAPANESE JOURNAL OF ORAL DIAGNOSIS/ORAL MEDICINE. 12,No.1. 38-46 (1999)

TETSURO ISHIGAMI、Kazumasa SUGIHARA、P.A.REICHART：“HIV 感染者牙周病的超微结构研究”日本口腔诊断/口腔医学杂志。

杉原一正: "ヒト免疫不全ウイルス感染症患者の口腔病変-臨床病態像とその電顕像について-" 鹿児島大学歯学部紀要. 18巻. 29-38 (1998)

Kazumasa Sugihara：“人类免疫缺陷病毒感染患者的口腔病变 - 临床病理特征及其电子显微镜图像”鹿儿岛大学牙科学院通报第 18 卷 29-38（1998）。

杉原 一正: "ヒト免疫不全ウィルス感染症患者の口腔病変-臨床病態像とその電顕像について-" 鹿児島大学歯学部紀要. 18. 31-40 (1998)

Kazumasa Sugihara：“人类免疫缺陷病毒感染患者的口腔病变 - 临床病理特征及其电子显微镜图像”鹿儿岛大学牙科学院通报 18. 31-40 (1998)。