Electron microscopic study on oral manifestations of human immunodeficiency virus infection

人类免疫缺陷病毒感染口腔表现的电镜研究

基本信息

批准号：
04671234
负责人：
SUGIHARA Kazumasa
金额：
$ 1.28万
依托单位：
KAGOSHIMA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1992
资助国家：
日本
起止时间：
1992 至 1993
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04671234/
关键词：
HIV-infection Oral manifestation Oral candidiasis Oral hairy leukoplkia Intraoral Kaosi's sarcoma Electron microscopic study Epstein-Barr virus 電子顕微鏡学的研究

项目摘要

Oral manifestations in HIV infection are numerous and some of these have been acknowledged as bing of great importance in early diagnosis of the disease. Oral manifestations in HIV-infected individuals occurred as mycotic, bacterial or viral infection, neoplasm or unknown etiology. Oral candidiasis occurring as pseudomembranous, hyperplastic and erythematous types should be considered. Oral hairy leukoplakia is characterized by whitish plaques at the lateral border of the tongue which cannot be rubbed off. Light microscopic investigations indicated that the lesion is characterized by parakeratosis, acanthosis, koilocytosis and lack of inflammation in the subepithelial tissue. Using electron microscopy, particles of the herpes virus group(Epstein-Barr virus) were found in the upper two thirds of the epithelium in this lesion.Oral hairy leukoplakia is an early sign of HIV infection and its importance relates to the development of AIDS(mostly Pneumocystis carinii pneumonia) in 83% of the affected patients within 31 months after its diagnosis. Electron microscopic study on intraoral Kaposi's sarcoma showed proliferating endothelial cells protruded into the lumen of the vascular space in the flat lesions. Exophytic lesions consisted of elongated spindle tumor cells and cleft-shaped, vessel-like lumina. Spindle tumor cells were characterized by intercellular junctions and Weibel-Palade bodies.

HIV 感染的口腔表现有很多，其中一些已被认为对该疾病的早期诊断非常重要。 HIV感染者的口腔表现表现为真菌、细菌或病毒感染、肿瘤或未知病因。应考虑假膜型、增生型和红斑型口腔念珠菌病。口腔毛状白斑的特征是舌头外侧边缘出现无法擦掉的白色斑块。光学显微镜检查表明，病变的特点是角化不全、棘层肥厚、空心细胞增多，上皮下组织无炎症。使用电子显微镜，在该病变的上皮上三分之二处发现了疱疹病毒组（EB病毒）的颗粒。口腔毛状白斑是艾滋病毒感染的早期征兆，其重要性与艾滋病的发展有关。 83% 的受影响患者在诊断后 31 个月内发生这种情况（主要是卡氏肺孢子虫肺炎）。口腔内卡波西肉瘤的电子显微镜研究显示，增殖的内皮细胞伸入扁平病变的血管腔内。外生性病变由细长的梭形肿瘤细胞和裂口状血管状管腔组成。梭形肿瘤细胞的特征是细胞间连接和 Weibel-Palade 小体。