Membranous mucin expression in oral squamous cell carcinoma and its clinical significance

口腔鳞癌中膜性粘蛋白的表达及其临床意义

• 批准号: 23390466
• 负责人: SUGIHARA Kazumasa
• 金额: $ 12.31万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390466/
• 关键词: 口腔癌; 膜型ムチン; MUC1; MUC4; 口腔扁平上皮癌; 予後規定因子; 転移; エピジェネティクス

MUC1 and MUC4 mucins are high molecular weight glycoproteins and help to protect and lubricate luminal surfaces under normal physiological conditions. The objective of the current study was to evaluate the prognostic significance of MUC1 and MUC4 expression in patients with oral squamous cell carcinoma (OSCC). Both MUC1 and MUC4 expression were found to be significantly correlated with tumor aggressiveness. In both mucins, the overall survival and disease-free survival rates were significantly worse for patients with expression compared with those without expression. In addition, these expressions were found to be an independent risk factor for subsequent regional lymph node metastasis. Taken together, these results suggest that patients with OSCC showing positive mucin expression should be followed up carefully, and that MUC1/MUC4 immunohistochemistry is a powerful indicator for tumor aggressiveness and can predict subsequent nodal metastasis and outcomes for patients with OSCC.

MUC1 和 MUC4 粘蛋白是高分子量糖蛋白，有助于在正常生理条件下保护和润滑管腔表面。本研究的目的是评估口腔鳞状细胞癌（OSCC）患者中MUC1和MUC4表达的预后意义。研究发现MUC1和MUC4的表达与肿瘤侵袭性显着相关。在这两种粘蛋白中，表达的患者的总生存率和无病生存率均显着低于不表达的患者。此外，这些表达被发现是随后区域淋巴结转移的独立危险因素。综上所述，这些结果表明，粘蛋白表达阳性的 OSCC 患者应仔细随访，MUC1/MUC4 免疫组织化学是肿瘤侵袭性的有力指标，可以预测 OSCC 患者随后的淋巴结转移和结局。

项目成果

口腔扁平上皮癌におけるMUC1ムチン上のDF3エピトープの発現は腫瘍悪性度, 後発リンパ節転移および予後不良と関連する

口腔鳞状细胞癌中MUC1粘蛋白上DF3表位的表达与肿瘤恶性、随后的淋巴结转移和不良预后相关

• 发表时间: 2014
• 期刊: 日本口腔外科学会雑誌
• 作者: 浜田倫史;野村昌弘;上川善昭;杉原一正
• 通讯作者: 杉原一正

Combination of MUC1 and MUC4 expression predicts clinical outcome in patients with oral squamous cell carcinoma

• DOI: 10.1007/s10147-014-0710-6
• 发表时间: 2015-04-01
• 期刊: INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
• 影响因子: 3.3
• 作者: Kamikawa, Yoshiaki;Kanmura, Yuji;Sugihara, Kazumasa
• 通讯作者: Sugihara, Kazumasa

Aberrant DNA Methylation of Tumor-Related Genes In Oral Rinse: A Noninvasive Method for Detection/Screening of Oral Squamous Cell Carcinoma.

口腔冲洗液中肿瘤相关基因的异常 DNA 甲基化：口腔鳞状细胞癌检测/筛查的非侵入性方法。

• 作者: Hamada T;Nagata S;Kanmura Y;Nomura M;Kamikawa Y;Mukai H;Sugihara K.
• 通讯作者: Sugihara K.

口腔癌の診断と治療戦略 基礎そして臨床から-口腔癌の先端研究に基づいた近未来的治療戦略について-「口腔外科の立場から」

口腔癌诊治策略：从基础到临床研究——基于口腔癌前沿研究的未来治疗策略——《从口腔外科角度》

• 发表时间: 2012
• 作者: 山村佳子;茂木勝美;青田桂子;東 雅之;浜田倫史
• 通讯作者: 浜田倫史

DF3 epitope expression on MUC1 mucin is associated with tumor aggressiveness, subsequent lymph node metastasis, and poor prognosis in patients with oral squamous cell carcinoma

• DOI: 10.1002/cncr.27542
• 发表时间: 2012-11-01
• 期刊: CANCER
• 影响因子: 6.2
• 作者: Hamada, Tomofumi;Nomura, Masahiro;Sugihara, Kazumasa
• 通讯作者: Sugihara, Kazumasa