Electron microscopic study on oral manifestations of human immunodeficiency virus infection

人类免疫缺陷病毒感染口腔表现的电镜研究

基本信息

批准号：
06672009
负责人：
SUGIHARA Kazumasa
金额：
$ 1.28万
依托单位：
KAGOSHIMA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

项目摘要

Oral manifestations in HIV infection are numerous and some of these have been acknowledged as being of great importance in early diagnosis of the disease. Oral manifestations in HIV-infected individuals occured as mycotic, bacterial or viral infection, neoplasm or unknown etiology. Oral hairly leukoplakia is characterized by whitish plaques at the lateral border of the tongue which cannot be rubbed off. Light microscopic investigations indicated that the lesion is characterized by parakeratosis, acanthosis, koilocytosis and lack of inflammation in the subepithelial tissue. Using electron microscopy, particles of the herpes virus group (Epstein-Barr virus ; EBV) were found in the upper two thirds of the epithelium in this lesion. In the stratum spinosum, clumps of condensed chromatin with a punched-out appearance and EBV capsids in different stages of assembly were densely packed in the nucleus. Oral hairy leukoplakiais an early sign of HIV infection and its importance relates to the develop-ment of AIDS (mostly Pneumocystitis carinii pneumonia) in 83% of the affectedpatients within 31 months after its diagnosis. Electron microscopic study on intraoral Kaposi's sarcoma showed proliferating endothelial cells protruded into the lumen of the vascular space in flat lesions. Exophytic lesions consisted of elongated spindle tumor cells and cleft-shaped, vessel-like lumina. Spindle tumor cells were characterized by intracellular junctions and Weibell-Palade bodies. Electron microscopic study on oral candidiasis showed many penetrating thread-like fungae of Candida albicans over the squamous epithelium.

艾滋病毒感染中的口服表现很多，其中一些被认为在早期诊断该疾病中非常重要。艾滋病毒感染个体的口服表现为霉菌，细菌或病毒感染，肿瘤或未知病因。口腔毛状白细胞的特征是在舌头的侧面边框上发白斑块，无法擦掉。光学显微镜研究表明，病变的特征是草原病，棘皮动物，koilocyocyposis和上皮下组织中缺乏炎症。使用电子显微镜，在该病变的上皮上三分之二的上三分之二中发现了疱疹病毒组（Epstein-Barr病毒； EBV）的颗粒。在脊柱层中，将浓缩的染色质和带有打孔的外观和在不同组装不同阶段的EBV衣壳中密集地包装在细胞核中。口服毛状白血病是艾滋病毒感染的早期迹象，其重要性与83％的受影响的患者在诊断后的31个月内有83％的艾滋病（主要是肺炎肺炎肺炎）的发展有关。对口腔内Kaposi的肉瘤的电子显微镜研究表明，在扁平病变中，内皮细胞增殖到血管空间的腔内。外生病变由伸长的纺锤体肿瘤细胞和left形的lumine裂片组成。纺锤体肿瘤细胞的特征是细胞内连接和微生型体。对口腔念珠菌病的电子显微镜研究表明，在鳞状上皮上，白色念珠菌的多穿透线真菌。