The elucidation of the mechanism and pathogenesis of severe drug eruption.

阐明重症药疹的机制和发病机制。

• 批准号: 22791085
• 负责人: TAKAHASHI Ryo
• 金额: $ 2.5万
• 依托单位: Kyorin University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791085/
• 关键词: regulatory T cell; SJS; TEN; マイコプラズマ肺炎; 皮膚免疫

Mycoplasma pneumoniae(MP) infection is related in the pathogenesis of Stevens-Johnson syndrome(SJS) which is severe drug eruption. However, its causal relationship is unclear. We previously found that the functional activity of regulatory T(Treg) cells was impaired in the acute stage of SJS. We therefore investigated whether Treg cells were related to development of SJS. The functional activity of Tregs was profoundly impaired during the acute phase of infection with MP, varicella-zoster virus, and parvovirus B19.In particular, the impaired Treg function was associated with a decrease in the CCR6+Tregs in infection with MP but not with other viral infections. Upon resolution, however, the impaired Treg function had been restored in viral infections, while it remained abrogated even 1year after infection with MP. Our findings suggest that MP infections could serve to enhance the risk of subsequently developing severe allergic diseases by chronically abrogating Treg-mediated suppression.

肺炎支原体（MP）感染与重症药疹史蒂文斯-约翰逊综合征（SJS）的发病有关。但其因果关系尚不清楚。我们之前发现调节性T（Treg）细胞的功能活性在SJS急性期受损。因此，我们研究了 Treg 细胞是否与 SJS 的发生有关。在MP、水痘带状疱疹病毒和细小病毒B19感染的急性期，Tregs的功能活性严重受损。特别是，MP感染时，Tregs功能受损与CCR6+Tregs的减少有关，但与MP感染时的CCR6+Tregs减少无关。其他病毒感染。然而，在解决后，病毒感染中受损的 Treg 功能已恢复，而即使在 MP 感染一年后，它仍然被消除。我们的研究结果表明，MP 感染可能会通过长期消除 Treg 介导的抑制来增加随后发生严重过敏性疾病的风险。

项目成果

マイコプラズマ感染はDIHS発症を抑制する

支原体感染抑制 DIHS 的发展

• 发表时间: 2011
• 作者: 水川良子; 狩野葉子; 高橋良; 塩原哲夫
• 通讯作者: 塩原哲夫

重症薬疹とレギュラトリーT細胞

严重药疹与调节性T细胞

• 发表时间: 2010
• 作者: 高橋良

制御性T細胞と重症薬疹

调节性 T 细胞和严重药疹

• 发表时间: 2011
• 作者: 石田正; 高橋良; 塩原哲夫
• 通讯作者: 塩原哲夫

Differences in immunological alterations and underlying viral infections in two well-defined severe drug eruptions

两次明确的严重药疹中免疫学改变和潜在病毒感染的差异

• 发表时间: 2010
• 影响因子: 4.1
• 作者: Hirahara K; Kano Y; Mitsuyama Y; Takahashi R; Kimishima M; Shiohara T
• 通讯作者: Shiohara T

Differences in immunological alterations and underlying viral infections in two well-defined severe drug eruptions.

两次明确的严重药疹中免疫学改变和潜在病毒感染的差异。

• 发表时间: 2010
• 影响因子: 4.1
• 作者: Hirahara K; Kano Y; Mitsuyama Y; Takahashi R; Kimishima M; Shiohara T
• 通讯作者: Shiohara T