Disturbance of Integral of Cerebral Hemispheres in Fuvctional Psychoses

功能性精神病中大脑半球积分紊乱

基本信息

批准号：
60304063
负责人：
TAKAHASHI Ryo
金额：
$ 7.04万
依托单位：
Tokyo Medical and Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Co-operative Research (A)
财政年份：
1985
资助国家：
日本
起止时间：
1985 至 1987
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60304063/
关键词：
Functional Psychoses Integral Function of Cerebral Hemispheres Neuropsychology Eye Movements Event-relsted Potential CNV Regional Blood Flow MRI-CT 脳局所血流核磁気共鳴脳断層撮影精神分裂病

项目摘要

DISTURBANCE OF INTEGRAL FUNCTION OF CEREBRAL HEMISPHERES IN FUNCTIONAL PSYCHOSES This project was conducted to clarify the disturbance of differential and integral functions of the cerebral hemisperse in functional psychoses using multi-dimentional methods. The relationships between right and left hemispheres as well as cortical and subcortical areas, and frontal and posterior regions were explored using neurophysiologicsl, psychophysiological, neuropsychological and morphological methods. Dr.Torii,H. explored the mirror writing and age desorientation in schizophrenia, Dr.Hozaki,H. distinguished schizophrenics from patients with frontal lobe lesion using the new modified Wisconsin Card Sorting Test.Dr.Okuma,T. showed the cerebral lateralization in functional psychosis measured by horizontal eye movements, Dr.Takahashi,R. examined the relationship between clinical symptoms and the tempo measuted by eye movements and he also studied the cerebral lateralization of eye fixations and moveme … More nts in temporal lobe spilepsy compared to focal sides of spikes.Dr.Takahashi, S. sutdied the interhemispheric dysgunction on verbal tasks in schizophrenia using CNV. Dr.Niwa showed event-related potential correlates of psychotropic drug effects on attentional and hemispheric dysfunction in schizophrenia. Dr.Machiyama,Y. also studied the event-related potential to clarify the topographic and temporal aspects of information processing abnormalities in schizophrenia. Dr.Yamaguchi,N.examined the regional blood flow in schizophrenics and depressed patients.Dr.Inanaga,K. examined morphological changes in the brains of schizophrenics using MRI-CT. From the view point of right and left hemispheric functions,most of our studies suggested thst schizophrenics had a left hemispheric dysfunction rather than the right one. The neurophysiological report suggested that the predominant side of cerebral hemispheric function was changeable according to the prognosis or types of schizophrenia such as a paranoid and a non-paranoid. Although the hypofrontality theory of schizophrenia is prevalent, the results obtained in our project were not consistent with the theory and suggested not only frontal lobe but aiso the other regions such as limbic system, thalamic muclei and basal ganglia may be involved to produce a schizophrenia.These collaborative studies had been done for 3 yesrd was very fruitful for the clarification of pathophysiological mechanism of schizophrenia. Less

功能性精神病中大脑半球的积分功能紊乱该项目旨在利用多维方法阐明功能性精神病中大脑半球的微分和积分功能紊乱，以及左右半球以及皮质和皮质下区域之间的关系。使用神经生理学、心理生理学、神经心理学和形态学方法探索额叶和后部区域。 Torii,H. 博士探索了精神分裂症中的镜像书写和年龄迷失，Hozaki,H. 博士使用新改良的威斯康星卡片分类测试区分了精神分裂症患者和额叶病变患者。通过水平眼球运动测量功能性精神病，Takahashi,R 博士检查了临床症状与眼球运动测量的节奏之间的关系，他还研究了大脑偏侧化。与尖峰的焦点侧相比，颞叶癫痫中的眼睛注视和运动的变化。Takahashi, S. 博士使用 CNV 研究了精神分裂症中言语任务的半球间失调，显示了精神药物作用与事件相关的潜在相关性。关于精神分裂症的注意力和半球功能障碍，Machiyama,Y 博士还研究了事件相关电位，以阐明地形和时间。精神分裂症的信息处理异常方面。Yamaguchi,N. 检查了精神分裂症患者和抑郁症患者的局部血流。Inanaga,K. 使用 MRI-CT 检查了精神分裂症患者大脑的形态变化。和左半球功能，我们的大多数研究表明精神分裂症患者有左半球功能障碍，而不是右半球功能障碍神经生理学报告表明：大脑半球功能的主导侧根据精神分裂症的预后或类型（例如偏执型和非偏执型）而变化。不仅是额叶，其他区域如边缘系统、丘脑核和基底神经节也可能参与精神分裂症的产生。这些合作研究3年的工作对于阐明精神分裂症的病理生理机制非常富有成效。