Functional analysis of regulatory T cells in patient of drug hypersensitivity syndrome

药物超敏综合征患者调节性T细胞的功能分析

• 批准号: 20790815
• 负责人: TAKAHASHI Ryo
• 金额: $ 2.66万
• 依托单位: Kyorin University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790815/
• 关键词: 皮膚炎症; 再生学; regulatory T cell; DIHS; SJS; ホーミング; 皮膚免疫

We investigated whether regulatory T cells (Treg cells) associated with the pathogenesis of severe drug eruptions. We have fined that the number of Treg cells and the expression of skin-homing receptors on Treg cells was significantly different between Drug-induced Hypersensitivity Syndrome (DIHS) and Stevens-Johnson Syndrome (SJS).

我们研究了调节性 T 细胞（Treg 细胞）是否与严重药疹的发病机制相关。我们发现，药物诱导的超敏反应综合征（DIHS）和史蒂文斯-约翰逊综合征（SJS）之间的 Treg 细胞数量和 Treg 细胞上皮肤归巢受体的表达存在显着差异。

项目成果

Trafficking receptor expression on regulatory t cells in severe drug eruptions

严重药疹中调节性 T 细胞上的转运受体表达

• 发表时间: 2008
• 作者: Takahashi R; et.al.
• 通讯作者: et.al.

Update on regulators: regulatory T cells in DIHS/DRESS and SJS/TEN.

调节器更新：DIHS/DRESS 和 SJS/TEN 中的调节性 T 细胞。

• 发表时间: 2008
• 作者: Shiohara T; Kano Y; Takahashi R
• 通讯作者: Takahashi R

Trafficking receptor expression on regulatory t cells in severe drug eruptions

严重药疹中调节性 T 细胞上的转运受体表达

• 发表时间: 2008
• 作者: Takahashi R; Shiohara T
• 通讯作者: Shiohara T

Defective Regulatory T Cells In Patients with Severe Drug Eruptions : Timing of the Dysfunction Is Associated with the Pathological Phenotype and Outcome

严重药疹患者的调节性 T 细胞有缺陷：功能障碍发生的时间与病理表型和结果相关

• 发表时间: 2009
• 作者: Ryo Takahashi; Yoko Kano; Yoshimi Yamazaki; Momoko Kimishima; Yoshiko Mizukawa; Tetsuo Shiohara
• 通讯作者: Tetsuo Shiohara

Association between drug and human herpesvirus in drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms.

药物和人类疱疹病毒在药物引起的过敏综合征/药疹中与嗜酸性粒细胞增多和全身症状的关联。

• 发表时间: 2008
• 作者: Kano Y; Hirahara K; Asano Y; Mitsuyama Y; Takahashi R; Shiohara T
• 通讯作者: Shiohara T