Development of new technology for controlling suture remodeling using magnetized liposome with liposome

脂质体磁化脂质体控制缝线重塑新技术的开发

• 批准号: 23659963
• 负责人: MORIYAMA Keiji
• 金额: $ 2.33万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659963/
• 关键词: リラキシン; リラキシンレセプター; 磁性リポソーム; 顎顔面頭蓋発生; 骨代謝; リポソーム; 骨芽細胞; 骨縫合部; ナノテクノロジー; 磁気制御; 破骨細胞

Relaxin is a pleiotropic hormone of the insulin like peptide hormonefamily.Rxfp1, Rxfp2 mRNA were expressed intensely in the developing mouse (E13.5~17.5)brain, bone, tongue muscle, dental lamina, tooth primordia. This finding indicated thatRelaxin and its receptor play an important role in the craniofacial development.Additionally, we determined the effect of Relaxin on the phenotypes of osteoblasts. Fromthe results of siRNA targeting experiments, Rxfp2 was probed to play important roles indifferentiation, mineralization, and matrix metabolism of the osteoblasts.

松弛素是胰岛素样肽激素家族的多效性激素。Rxfp1、Rxfp2 mRNA在发育中的小鼠(E13.5~17.5)脑、骨、舌肌、牙板、牙原基​​中强烈表达。这一发现表明Relaxin及其受体在颅面发育中发挥着重要作用。此外，我们还确定了Relaxin对成骨细胞表型的影响。 siRNA靶向实验结果表明Rxfp2在成骨细胞的分化、矿化和基质代谢中发挥重要作用。

项目成果

Clinical correlate: cleidocranial dysplasia.

临床相关：锁骨颅骨发育不良。

• 发表时间: 2012
• 作者: Takeda S;Haga N;Moriyama K.
• 通讯作者: Moriyama K.

骨との結合が3倍速くなるコーティング法を開発 矯正歯科用骨膜下デバイスなどで患者の負担軽減を目指す

开发一种涂层方法，与骨骼的融合速度提高三倍旨在减轻骨膜下正畸装置患者的负担

Mineralized tissues in oral and craniofacial science

口腔和颅面科学中的矿化组织

• 发表时间: 2012
• 作者: McCauley LK.;et al.
• 通讯作者: et al.

Differential articulatory movements during Japanese /s/ and /t/ as revealed by MR image sequences with tooth visualization

• DOI: 10.1016/j.archoralbio.2011.11.002
• 发表时间: 2012-06-01
• 期刊: ARCHIVES OF ORAL BIOLOGY
• 影响因子: 3
• 作者: Ng, Inn Wo;Ono, Takashi;Moriyama, Keiji
• 通讯作者: Moriyama, Keiji

Orthognathic treatment for a patient with facial asymmetry associated with unilateral scissors-bite and a collapsed mandibular arch

一例伴有单侧剪状咬合和下颌弓塌陷的面部不对称患者的正颌治疗

• DOI: 10.1016/j.ajodo.2010.02.042
• 发表时间: 2012
• 期刊: Am J Orthod Dentofacial Orthop
• 作者: Suda N.;et.al.
• 通讯作者: et.al.