Sexual maturation in Growth hormone receptor deficiency chicken.

生长激素受体缺乏鸡的性成熟。

• 批准号: 23580389
• 负责人: TSUKADA Akira
• 金额: $ 3.49万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23580389/
• 关键词: 成長ホルモン; 成長ホルモン受容体; 成長ホルモン作用; 精巣; セルトリ細胞; ライディッヒ細胞; 精原細胞; 間質; セルトリ

Growth hormone (GH) plays a various role in controlling cell proliferation and development, nutrient metabolism, protein synthesis and reproduction as well as normal growth. GH actions are exerted after binding to GH receptor (GHR) localized in target tissues. Sex-linked dwarf (SLD) chicken lacking functional GHR is good experimental model for study of GH actions. We investigated effect of GHR deficiency on sexual maturation in chicken. Testicular GHR mRNA was expressed at 5-12 weeks old in male. Testicular GHR mRNA expression was high until 12 weeks old, but which was not detected in 16-weeks old and matured males. Maturation of seminiferous tubule in male was delayed in SLD chicken. Present results suggested that GH was directly or indirectly affected to sexual maturation. Especially, negative correlation with GHR mRNA expression and area of testicular tuble was suggested that GH strongly effect on testicular development, before spermatogenesis.

生长激素（GH）在控制细胞增殖和发育、营养代谢、蛋白质合成和繁殖以及正常生长方面发挥着多种作用。 GH 与靶组织中的 GH 受体 (GHR) 结合后发挥作用。缺乏功能性 GHR 的伴性侏儒 (SLD) 鸡是研究 GH 作用的良好实验模型。我们研究了 GHR 缺乏对鸡性成熟的影响。雄性睾丸GHR mRNA在5-12周龄时表达。睾丸 GHR mRNA 表达在 12 周龄前一直很高，但在 16 周龄和成熟雄性中未检测到。 SLD 鸡的雄性生精小管成熟延迟。目前的结果表明，GH 直接或间接影响性成熟。特别是，与 GHR mRNA 表达和睾丸小管面积呈负相关，表明 GH 在精子发生前对睾丸发育有强烈影响。

项目成果

成長ホルモン受容体欠損ニワトリにおける性成熟の遅延と遺伝子発現

生长激素受体缺陷鸡的性成熟延迟和基因表达

• 发表时间: 2012
• 作者: 塚田光;桑原力;佐橋学;笹浪知宏;道羅英夫;田中実
• 通讯作者: 田中実

Alleviation of body weight loss by dietary methionine is independent of insulin-like growth factor-I in protein-starved young chickens

• DOI: 10.1111/j.1740-0929.2010.00868.x
• 发表时间: 2011-01-01
• 期刊: ANIMAL SCIENCE JOURNAL
• 影响因子: 2
• 作者: Nagao, Kenji;Oki, Mai;Kita, Kazumi
• 通讯作者: Kita, Kazumi

Growth hormone receptor signalling in chicken

鸡的生长激素受体信号传导

• 发表时间: 2013
• 作者: Isaji Y;Murata M;Takaguchi N;Mukai T;Tajima Y;Imai H;Yamada M;Akira Tsukada and Ken-ichi Tahara
• 通讯作者: Akira Tsukada and Ken-ichi Tahara

Growth hormone receptor signalling in chicken.

鸡的生长激素受体信号传导。

• 发表时间: 2013
• 作者: Akira Tsukada;Ken-ichi Tahara
• 通讯作者: Ken-ichi Tahara

Retardation of sexual maturation in growth hormone receptor deficiency chicken

生长激素受体缺乏鸡性成熟迟缓

• 发表时间: 2012
• 作者: Miyamoto K;Nagai K;Kitamura N;Nishikawa T;Ikegami H;Binh NT;Tsukamoto S;Matsumoto M;Tsukiyama T;Minami N;Yamada M;Ariga H;Miyake M;Kawarasaki T;Matsumoto K;Imai H.;Riki Kuwahara and Akira Tsukada
• 通讯作者: Riki Kuwahara and Akira Tsukada