The epidemiological study on dioxin exposure, steroid hormone and prostatic cancer in Vietnam

越南二恶英暴露、类固醇激素与前列腺癌的流行病学研究

• 批准号: 23406018
• 负责人: KIDO Teruhiko
• 金额: $ 12.4万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23406018/
• 关键词: ダイオキシン類; ステロイドホルモン; 前立腺がん; 枯葉剤; ベトナム; 国際環境保健; 衛生; 環境; ダイオキシン; 前立腺特異抗原; 環境保健; 性ホルモン

To make clear the relation of dioxin exposure and steroid hormone and prostatic specific antigen (PSA), blood are collected from men at herbicide-sprayed and non-sprayed areas in Vietnam in 2010 and 2011.As results, total dioxin levels were significantly higher in herbicide-sprayed area. PSA was not different between two areas. On steroid hormone, testosterone and estradiol were significantly higher, while dehydroepiandrosterone was significantly lower in herbicide-sprayed area. Multiple regression analysis was performed after adjusting four factors such as age, BMI, present occupation and smoking. As results, no significant association was found between dioxins and each steroid hormone.

为了明确二恶英暴露与类固醇激素和前列腺特异性抗原（PSA）的关系，我们于 2010 年和 2011 年在越南喷洒除草剂和未喷洒除草剂的地区采集了男性血液。结果，总二恶英水平显着高于越南喷洒除草剂的区域。 PSA 在两个区域之间没有差异。在类固醇激素方面，在喷洒除草剂的地区，睾酮和雌二醇显着较高，而脱氢表雄酮显着较低。调整年龄、BMI、目前职业、吸烟等4个因素后进行多元回归分析。结果，没有发现二恶英和每种类固醇激素之间存在显着关联。

项目成果

Current elevated dioxin level in serum of Vietnamese old men : Past exposure or current exposure

目前越南老人血清中二恶英含量升高：过去接触或当前接触

• 发表时间: 2013
• 作者: Manh HD;Kido T;Okamoto R;Sun XL;Maruzeni S;Nishijo M;Nakagawa H;Honma S;Nakano T;Takasuga T;Nhu DD;Hung NN;Son LK
• 通讯作者: Son LK

Relationship between dioxin and steroid hormones in sera of Vietnamese men

越南男性血清中二恶英与类固醇激素的关系

• DOI: 10.3109/1354750x.2014.899626
• 发表时间: 2014
• 期刊: Biomarkers
• 影响因子: 2.6
• 作者: Sun XL;Kido T;Okamoto R;Manh HD;Maruzeni S;Nishijo M;Nakagawa H;Honma S;Nakano T;Takasuga T;Nhu DD;Hung NN;Son LK
• 通讯作者: Son LK

The relationship between dioxin and steroid hormones in serum of Vietnamese men

越南男性血清中二恶英与类固醇激素的关系

• 发表时间: 2013
• 作者: Sun XL;Kido T;Okamoto R;Manh HD;Maruzeni S;Nishijo M;Nakagawa H;Honma S;Nakano T;Takasuga T;Nhu DD;Hung NN;Son LK
• 通讯作者: Son LK

Dioxin concentration in serum of Vietnamese men

越南男性血清中二恶英浓度

• 作者: Sun XL;Kido T;Okamoto R;Manh HD;Maruzeni S;Nishijo M;Nakagawa H;Honma S;Nakano T;Takasuga T;Nhu DD;Hung NN;Son LK;Ho Dung Manh
• 通讯作者: Ho Dung Manh

Serum Dioxin Levels in Vietnamese Men more than 40 Years after Herbicide Spraying

• DOI: 10.1021/es404853h
• 发表时间: 2014-03-18
• 期刊: ENVIRONMENTAL SCIENCE & TECHNOLOGY
• 影响因子: 11.4
• 作者: Ho Dung Manh;Kido, Teruhiko;Le Ke Son
• 通讯作者: Le Ke Son