The study on the source of environmental pollution by dioxins in Vietnam based on the ratio of dioxin-isomers

基于二恶英异构体比例的越南二恶英环境污染来源研究

• 批准号: 17406016
• 负责人: KIDO Teruhiko
• 金额: $ 9.18万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17406016/
• 关键词: Dioxin; Vietnam; Herbicide; Environmental pollution; Isomer; Food chain; International health; 環境保健

The purpose of this study was to clarify the source of environmental pollution by dioxins in Vietnam based on the ratio of dioxin-isomers. Since 2005, the researches were conducted every year for 3 years at herbicide sprayed Cam Chinh commune in Quang Tri province and non-sprayed Cam Phuc commune, Ha Tinh province in Vietnam respectively. As environmental material,27 soils (20 in the sprayed area and 7 in the non-sprayed area) were collected. As human material, 156 breast milk (84 in the sprayed area and 72 in the non-sprayed area) and pooled serum collected from 284 sera (144 in the sprayed area and 140 in the non-sprayed area) were analyzed. As results, dioxin concentration in soil was significantly higher in the sprayed area and in the non-sprayed area. Among isomers, 2,3,7,8-TCDD was also significantly higher in the spared area. In human samples, our result showed that isomers were significantly superior in the sprayed area concentrated on PCDFs rather than PCDDs. Isomers such as 1,2,3,4,6,7,8-HpCDD, 1,2,3,4,7,8-HxCDF, 1,2,3,6,7,8-HxCDF, 1,2,3,4,6,7,8HpCDF and 1,2,3,4,7,8,9-HpCDF were not always similar to those in the non-sprayed area. They were prominent isomers in the sprayed area. Our studies clearly showed that these five isomers were characteristic isomers in the sprayed area which determine a quality or a feature of exposure to dioxin. In conclusion, we revealed areal differences of concentration levels of 2,3,7,8-substituted isomers in human specimen and suggested level differences of the isomers were attributed to a quality or a feature of exposure sources in the area.

本研究的目的是根据二恶英异构体的比例来澄清越南二恶英环境污染的来源。自2005年起，每年分别在越南广治省喷洒除草剂Cam Chinh公社和河静省未喷洒除草剂Cam Phuc公社进行研究，为期三年。作为环境材料，收集了 27 块土壤（喷洒区域 20 块，非喷洒区域 7 块）。作为人类材料，对 156 份母乳（84 份在喷雾区域，72 份在非喷雾区域）和从 284 份血清（144 份在喷雾区域，140 份在非喷雾区域）收集的混合血清进行了分析。结果表明，喷洒区域和非喷洒区域土壤中二恶英浓度明显较高。在异构体中，2,3,7,8-TCDD 在未受影响的区域也显着较高。在人体样本中，我们的结果表明，在集中于 PCDF 而非 PCDD 的喷涂区域中，异构体明显优于 PCDD。异构体，如 1,2,3,4,6,7,8-HpCDD、1,2,3,4,7,8-HxCDF、1,2,3,6,7,8-HxCDF、1,2 ,3,4,6,7,8HpCDF 和 1,2,3,4,7,8,9-HpCDF 并不总是与非喷涂区域相似。它们是喷涂区域中突出的异构体。我们的研究清楚地表明，这五种异构体是喷雾区域的特征异构体，决定了二恶英暴露的质量或特征。总之，我们揭示了人类样本中 2,3,7,8-取代异构体浓度水平的区域差异，并建议异构体的水平差异归因于该区域暴露源的质量或特征。

项目成果

FIVE YEARS STUDIES ON THE LONG TERM EFFECTS OF WAR AGENT ORANGE/DIOXIN ON HUMAN HEAIiTH IN VIETNAM

关于橙剂/二恶英对越南人类健康的长期影响的五年研究

• 发表时间: 2007
• 作者: Kido T;Suzuki H;Naganuma R;Tawara K;Nishijo M;Nakagawa H;Hung TM;Thorn LTH;Dung PT;Nhu DD.;Kido T
• 通讯作者: Kido T

An Epidemiological study on health effects by dioxin in Vietnam : Comparison of contrast acuity between inhabitants of herbicide sprayed and non-sprayed areas.

越南二恶英对健康影响的流行病学研究：喷洒除草剂和未喷洒除草剂地区居民对比敏锐度的比较。

• 发表时间: 2006
• 期刊: Organohalogen Compounds 68
• 作者: Tawara K;Nishijo M;Nakagawa H;Kido T;Naganuma R;Suzuki H;Hung TM;Thom LTH;Dung PT;Nhu DD.;岡 秀雄;Kido T.
• 通讯作者: Kido T.

An Epidemiological study on health effects by dioxin in Vietnam ; Comparison of contrast acuity between inhabitants of herbicide sprayed and non-sprayed areas.

越南二恶英对健康影响的流行病学研究；

• 发表时间: 2006
• 期刊: Organohalogen Compounds 68
• 作者: Kido T;Suzuki H;Naganuma R;Tawara K;Nishijo M;Nakagawa H;Hung TM;Thorn LTH;Dung PT;Nhu DD.
• 通讯作者: Nhu DD.

ベトナムの土壌及び底質試料のダイオキシン類分析結果について

关于越南土壤和沉积物样品的二恶英分析结果

• 发表时间: 2007
• 期刊: 石川保健環境センター研究報告書(H18年度) 44
• 作者: Tawara K;Nishijo M;Nakagawa H;Kido T;Naganuma R;Suzuki H;Hung TM;Thom LTH;Dung PT;Nhu DD.;岡 秀雄
• 通讯作者: 岡 秀雄

Association of having birth defect children with serum dioxin levels in Vietnam.

越南出生缺陷儿童与血清二恶英水平的关联。

• 发表时间: 2007
• 期刊: Organohalogen Compounds 69
• 作者: Michael Reinsch;Takuo Watanabe;Naoyuki Nagatou;Michael Reinsch;山田聖;Kido T.;Tawara K.
• 通讯作者: Tawara K.