The epidemiological study on human adverse health effects 30 years after sprayed dioxins polluted environment in Vietnam

越南喷洒二恶英污染环境30年后人体健康不良影响的流行病学研究

• 批准号: 14406011
• 负责人: KIDO Teruhiko
• 金额: $ 8.19万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14406011/
• 关键词: Dioxins; Vietnam; Herbicide; Environmental pollution; Epidemiology Study; International Health; 国際研究者交流

To examine dioxins levels in human specimen including breast milk, adipose tissue and serum and their relation with human adverse health effects over 30 years after sprayed dioxins polluted Vietnamese environment, Vietnamese inhabitants of two villages in central part of Vietnam were selected in four examinations between 2002 and 2004. Dioxin-exposed area is located in Cam Chinh commune in Quang Tri province where herbicides were sprayed (abbreviate Quang Tri to QT), while Cam Phuc commune in Ha Tinh province (abbreviate Ha Tinh to HT) is selected as control area where herbicides were not sprayed during the War. These two communes were separated by the demilitarized zone of latitude 17 degrees north line that was a military boundary in Vietnam War.Quantitation was performed by a high resolution mass spectrometer (HRMS ; JEOL MStation-JMS700) equipped with a gas chromatograph (HP-6980).Dioxin levels of human samples including breast milk, adipose tissue and serum in people in herbicide-exposed area in Vietnam is significantly higher than those in people in dioxin-unexposed control area. However, TCDD contributed less than 20% of the total I-TEQ in most samples. These results were different from the former reports that TCDD was a useful indicator for toxicity of Agent Orange since TCDD occupied most of dioxins. It is necessary to investigate the origin of 1,2,3,7,8-PCDD and 2,3,4,7,8-PCDF which were the most contributor in the total TEQ in this study.Biochemical indicators in sera such as liver or thyroid functions were not significantly different between two groups. Significant negative correlations were showed between Total PCDD/Fs and cholinesterase of mothers. Dioxin concentration in breast milk has significant association with chest measurement of infants after adjustment of age of infants although our results did not show difference between the growths of infants in two areas.

为了检测喷洒二恶英污染越南环境30多年来人体样本（包括母乳、脂肪组织和血清）中二恶英的含量及其与人类不良健康影响的关系，2002年期间对越南中部两个村庄的越南居民进行了四次检查和 2004 年。二恶英暴露地区位于广治省 Cam Chinh 公社，该乡喷洒了除草剂（Quang Tri 缩写为 QT），而 Cam Chinh 公社喷洒了除草剂（缩写 Quang Tri 为 QT）。河静省Phuc公社（简称HT）被选为战争期间未喷洒除草剂的对照区。这两个公社被北纬 17 度线非军事区分隔开，该非军事区是越南战争中的军事边界。通过配备气相色谱仪 (HP-6980) 的高分辨率质谱仪 (HRMS; JEOL MStation-JMS700) 进行定量）。越南除草剂暴露地区人群的母乳、脂肪组织和血清等人体样本中二恶英含量显着高于越南人群二恶英未暴露控制区。然而，在大多数样品中，TCDD 贡献的总 I-TEQ 不到 20%。这些结果与之前的报道不同，由于TCDD占据了二恶英的大部分，因此TCDD是橙剂毒性的有用指标。本研究中对总TEQ贡献最大的1,2,3,7,8-PCDD和2,3,4,7,8-PCDF有必要对其来源进行调查。血清中的生化指标如两组之间的肝脏或甲状腺功能没有显着差异。母亲体内总PCDD/Fs与胆碱酯酶呈显着负相关。调整婴儿年龄后，母乳中的二恶英浓度与婴儿的胸部测量值显着相关，尽管我们的结果并未显示婴儿在两个区域的生长情况存在差异。

项目成果

科学的綱領 : 戦争中に枯葉剤(ダイオキシン)が散布されたクワァンチ州カムロ地区カムチン村住民の長期間の健康影響

科学原理：战争期间喷洒落叶剂（二恶英）的宽奇省卡姆洛区卡姆钦村居民的长期健康影响

• 发表时间: 2002
• 作者: 城戸照彦 他

ベトナムにおけるダイオキシンの健康影響に関する疫学研究

越南二恶英对健康影响的流行病学研究

• 发表时间: 2004
• 期刊: 平成11年度〜15年度私立大学学術研究高度化推進事業(ハイテク・リサーチ・センター)研究成果報告書
• 作者: 城戸照彦;長沼理恵;丸銭笑子;西条旨子;中川秀昭;俵健二
• 通讯作者: 俵健二

Report on dioxins levels in human specimen including breast milk, adipose tissue and serum and their relations with human health effects in Vietnam.

关于越南人体样本（包括母乳、脂肪组织和血清）中二恶英含量及其与人类健康影响的关系的报告。

• 发表时间: 2005
• 期刊: 10-80 Division, Vietnam Health Ministry
• 作者: Yajima S;Nakamura K;Takano T.;Someya K.;Ichihara G. et al.;Teruhiko Kido et al.
• 通讯作者: Teruhiko Kido et al.

An epidemiological study on the long term effects of war agent orange/dioxin on human health in Vietnam

越南战剂橙/二恶英对人体健康的长期影响的流行病学研究

• 发表时间: 2004
• 期刊: Workshop document on results of collaborative study between 10-80 Division and Kanazawa University
• 作者: Teruhiko Kido;Rie Naganuma;Shoko Maruzeni;Kenji Tawara
• 通讯作者: Kenji Tawara

Tawara K, Nishijo_M, Nakagawa M. Honnda R, Kido T: "World wide trends of dioxin levels in human breast milk. With comparison between Toyama Prefecture I Japan and other areas"1^<st> International Symposium of the Kanazawa University 21^<st>-century COE Pr

Tawara K、Nishijo_M、Nakakawa M. Honnda R、Kido T：“母乳中二恶英含量的全球趋势。日本富山县与其他地区的比较”1^<st>金泽大学国际研讨会 21^