The molecular epidemiological study on dioxin exposure and prevalence of hypertrophic cardiomyopathy in Vietnam

越南二恶英暴露和肥厚性心肌病患病率的分子流行病学研究

• 批准号: 22659122
• 负责人: KIDO Teruhiko
• 金额: $ 1.96万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22659122/
• 关键词: 環境保健; 社会医学; ダイオキシン類; 肥大型心筋症; ベトナム; 分子疫学; 環境; 枯葉剤; 遺伝子解析; 国際保健

This study is a series of epidemiological studies on dioxin exposure and human health effects in Vietnam. The aim of this study is to make clear the prevalence of hypertrophic cardiomyopathy and examine mutations in its genes. Subjects consists of 500 individual men aged over 40 years old in a herbicide contaminated area and a control area, respectively. The first screening was conducted using electric cardiogram. As results, 7 men were suspected as cardiomegaly. Five men among them were examined using ultrasonic equipment. However, no one was found as hypertrophic cardiomyopathy. It would be suggested that the prevalence of hypertrophic cardiomyopathy is not so frequent

这项研究是关于越南二恶英暴露和人类健康影响的一系列流行病学研究。本研究的目的是明确肥厚型心肌病的患病率并检查其基因突变。受试者由分别位于除草剂污染区和对照区的 500 名 40 岁以上男性组成。第一次筛查是使用心电图进行的。结果，7名男子被怀疑患有心脏肥大。其中五名男子接受了超声波设备检查。然而，没有人被发现患有肥厚型心肌病。这表明肥厚型心肌病的患病率并不那么频繁