Fundamental and clinical assessment of F-18 Choline as a new cancer tracer for PET

F-18 胆碱作为新型 PET 癌症示踪剂的基础和临床评估

• 批准号: 21592398
• 负责人: SHOZUSHIMA Masanori
• 金额: $ 2.75万
• 依托单位: Iwate Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592398/
• 关键词: PET; 18F-コリン; FDG-PET; 放射線; 歯学; 口腔癌; choline; 癌; Choline

This study evaluated the potential usefulness of[^<18> F] Choline as a new cancer tracer for PET. The uptake of[^<18> F] Choline and[^<18> F] FDG are cell cycle dependent, are associated with the proliferative activity of the tumor seen during PET imaging. The average SUVs of[^<18> F] FDG for the gingival cancer infiltrated jawbone was markedly higher than that for the tongue. The average SUVs of[^<11> C] or[^<18> F] Choline were showing no significant difference between the tongue and gingival cancer, and the same level as[^<18> F] FDG uptake for the tongue cancer. It seems that[^<18> F] Choline is not well incorporated to the osteogenetic cell and the osteoclast related to bone metabolism but accumulation for the cancer cells.

这项研究评估了[^<18> f]胆碱作为PET的新癌症示踪剂的潜在有用性。 [^<18> f]胆碱的摄取和[^<18> f] FDG是细胞周期依赖性的，与PET成像过程中看到的肿瘤的增殖活性有关。牙龈癌浸润的牙龈肿瘤的平均SUV显着高于舌头。 [^<11> c]或[^<18> f]胆碱的平均SUV在舌头和牙龈癌之间没有显着差异，与舌癌的[^<18> f] FDG摄取的水平相同。看来[^<18> f]胆碱不能很好地掺入与骨骼代谢相关的成骨细胞和破骨细胞，而是癌细胞积累。

项目成果

[^<11> C] PK11195の迅速・効率的な合成法の開発

[^<11> C] PK11195快速高效合成方法的开发

• 发表时间: 2009
• 作者: 寺崎一典;石川洋一;岩田錬;後藤祥子;小豆島正典
• 通讯作者: 小豆島正典

「Q & A」で学ぶ歯科放射線学: SBOs

通过“问答”了解牙科放射学：SBO

• 发表时间: 2011
• 作者: 金田隆・小豆島正典;ほか10名
• 通讯作者: ほか10名

Central Benzodiazepine Receptor Binding Potential and CBF Images on SPECT Correlate with Oxygen Extraction Fraction Images on PET in the Cerebral Cortex with Unilateral Major Cerebral Artery Occlusive Disease

• DOI: 10.2967/jnumed.110.084186
• 发表时间: 2011-04-01
• 期刊: JOURNAL OF NUCLEAR MEDICINE
• 影响因子: 9.3
• 作者: Chida, Kohei;Ogasawara, Kuniaki;Ogawa, Akira
• 通讯作者: Ogawa, Akira

特別講演:口腔癌に対するFDG集積の特徴

专题讲座：口腔癌FDG蓄积特点

• 发表时间: 2011
• 作者: Yoshioka I;Tanaka T;Khanal A;Habu M;Kito S;Kodama M;Oda M;Wakasugi-Sato N;Matsumoto-Takeda S;Fukai Y;Tokitsu T;Tomikawa M;Seta Y;Tominaga K;Morimoto Y;小豆島正典
• 通讯作者: 小豆島正典

18F-Cholineによる口腔癌の診断

18F-胆碱诊断口腔癌

• 发表时间: 2010
• 作者: N. Watanabe;K. Endo;原 康文,寺崎一典,岩田 錬,小豆島正典
• 通讯作者: 原 康文,寺崎一典,岩田 錬,小豆島正典