Diagnosis of prostate cancer by the combined molecular imaging focused on [18F]choline-PET

[18F]胆碱-PET联合分子影像诊断前列腺癌

• 批准号: 23591793
• 负责人: SETSU Sakamoto
• 金额: $ 2.25万
• 依托单位: Dokkyo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591793/
• 关键词: 前立腺癌; 画像診断; ポジトロン断層撮像; [18F]コリン; MRI

As the country's population grows older, increase of prostate cancer is expected in future. We performed PET with the tracer [18F] fluorocholine (FCh) for 71 patients with strong suspicion of having prostate cancer, who were pathologically examined later, and for 8 patients with a suspicion of recurrence. The diagnostic performance of FCh-PET was equivalent to that of MRI, and the diagnosis of the distant metastasis by FCh-PET was almost good.There was much little number of patients requiring the FCh-PET for searching recurrence than anticipated. So we could hardly perform analysis for diagnostic ability of FCh-PET on the recurrence of prostate cancer during the three year study period, and will continue to get more patients who requires to be diagnosed whether there is recurrence or not. We experienced two cases (out of 79 scans) with unexpected lung cancer incidentally detected by FCh-PET.

随着该国人口的增长，预计将来会增加前列腺癌。我们用示踪剂[18F]氟胆碱（FCH）对71例强烈怀疑患有前列腺癌的患者进行了PET，后来对病理进行了病理检查，以及8例怀疑复发性的患者。 FCH-PET的诊断性能等于MRI的诊断性能，而FCH-PET对远处转移的诊断几乎是不错的。需要FCH-PET进行搜索复发的患者数量少于预期。因此，我们几乎无法对FCH-PET在三年研究期间对前列腺癌复发的诊断能力进行分析，并且将继续吸引更多需要诊断出是否复发的患者。我们经历了两例（在79次扫描中），其中FCH-PET偶然检测到了意外的肺癌。