The radiographic evaluation of choline uptake to the head and neck cancer by mean of PET

PET对头颈癌胆碱摄取的影像学评价

基本信息

批准号：
15592002
负责人：
SHOZUSHIMA Masanori
金额：
$ 1.92万
依托单位：
Iwate Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15592002/
关键词：
^<11>C-Choline PET head and neck cancer FDG 18Fコリンリンパ球

项目摘要

Positron emission tomography (PET) with FDG and ^<11>C-labeled choline (^<11>C-choline) has been shown to be useful in the staging and detection of cancer. The background of the increased uptake of FDG and choline in human cancer is not completely understood. The aim of this research were designed to address investigate the relationship between the ^<11>C-choline uptake and the cell-cycle-dependent of tumor cell, and the clinical value of PET with ^<11>C-choline for malignant head and neck tumors as compared with ^<18>F-fluorodeoxyglucose (FDG) PET.^<11>C-choline uptake was higher in the G2/M phase in HeLa S3 cells. In addition, FDG uptake was significantly higher in the early S phase and G2/M phase compared to the G1 phase. It has been concluded cell cycle dependency is reflected in the uptake of ^<11>C-choline and EDG, seen during PET imaging of tumor tissue.The relationship between the mean SUV and the following parameters was examined : histological grade of malignancy, degree of cell differentiation, size and/or local extent of the primary lesion, and cell density of tumor. The mean SUV, standardized uptake value normalized to FDG-uptake and the administered dose of radionuclide, the body weight of the patient, did not depend on the histological grade or the degree of cell differentiation, but tended to be greater the larger the primary lesion. SUV also depended on cell density ; the greater the percentage of tumor parenchyma, the higher the SUV.The cutoff SUV for differentiating malignant and benign lesions was 3.5 for FDG. ^<11>C-choline showed slightly better than FDG for residual tumor cell after radio-chemo therapy, although some overlap existed on both studies. ^<11>C-choline showed significantly faster accumulation than FDG into Malignant tumors. The advantages of ^<11>C-choline PET were shorter examination period. However, both ^<11>C-choline and FDG have some limitations in the evaluation of salivary gland lesions.

使用FDG和 11 C-标记胆碱( 11 C-胆碱)的正电子发射断层扫描(PET)已被证明可用于癌症的分期和检测。人类癌症中 FDG 和胆碱摄取增加的背景尚不完全清楚。本研究旨在探讨肿瘤细胞^<11>C-胆碱摄取与细胞周期依赖性之间的关系，以及^<11>C-胆碱PET检查对恶性肿瘤头部的临床价值。与 18 F-氟脱氧葡萄糖(FDG) PET相比，在颈部肿瘤和颈部肿瘤中的效果更好。HeLa S3细胞中G2/M期的 11 C-胆碱摄取更高。此外，与G1期相比，早期S期和G2/M期的FDG摄取量显着更高。已经得出结论，细胞周期依赖性反映在肿瘤组织PET成像期间观察到的^ 11 C-胆碱和EDG的摄取中。检查了平均SUV和以下参数之间的关系：恶性肿瘤的组织学分级、程度细胞分化、原发病变的大小和/或局部范围以及肿瘤的细胞密度。平均 SUV（根据 FDG 摄取量标准化的标准化摄取值和放射性核素的施用剂量）以及患者的体重，不依赖于组织学分级或细胞分化程度，但原发病变越大，SUV 往往越大。 SUV还取决于细胞密度；肿瘤实质百分比越大，SUV越高。FDG区分良恶性病变的截止SUV为3.5。 ^ 11 C-胆碱对于放化疗后残留肿瘤细胞的表现略好于FDG，尽管两项研究中存在一些重叠。 11 C-胆碱显示出比FDG显着更快的在恶性肿瘤中的积累。 11 C-胆碱PET的优点是检查周期较短。然而，11C-胆碱和FDG在评估唾液腺病变方面都具有一些局限性。