Lymph node metastasis of oral cancer with 18FDG-PET

18FDG-PET观察口腔癌淋巴结转移

基本信息

批准号：
09671929
负责人：
SHOZUSHIMA Masanori
金额：
$ 2.18万
依托单位：
Iwate Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1999
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671929/
关键词：
FDG PET head and neck cancer lymphnode metastasis Image diagnosis リンパ節転移頭頸部悪性腫瘍口腔癌

项目摘要

The image fusion of PET and CT from the head and neck region was performed with the use of external markers in 7 patients with squamous cell carcinoma. The purpose of this study was to examine a resultant error and clinical usefulness of the image fusion.Patients had primary lesion of the tongue, the maxillary gingiva or the maxillary sinus. All patients underwent PET with FDG and CT to detect tumor sites. Of these 7 patients, 6 cases were also pronounced regional lymph node metastasis to the neck from the diagnostic images and the clinical observation. To ensure anatomical detail of the PET images, small radioactive markers were placed on the philtrum and below both earlobes. The PET image and CT image were then overlapped each other on a computer.The image fusion of PET and CT was achieved in all patients. The superposition error of this method was examined between PET and CT images. The accuracy of fit measured as the mean distance between PET and CT image was in the range of 2 - 5 mm. PET-CT superimposed images produced localization of tumor FDG uptake increase and FDG uptake to palatine tonsil were also localized.The marker system described here for the alignment of PET and CT images can be used on a routine bases without the invasive fixation of external markers, improve the management and follow up of patients with head and neck carcinoma.

使用外部标记对 7 例鳞状细胞癌患者进行头颈部 PET 和 CT 图像融合。本研究的目的是检查图像融合所产生的误差和临床实用性。患者的原发病变位于舌头、上颌牙龈或上颌窦。所有患者均接受 PET FDG 和 CT 检测肿瘤部位。在这7例患者中，从诊断图像和临床观察来看，6例也有明显的颈部区域淋巴结转移。为了确保 PET 图像的解剖细节，在人中和两个耳垂下方放置了小型放射性标记。然后将PET图像和CT图像在计算机上相互重叠。所有患者均实现PET和CT图像融合。检验了该方法在 PET 和 CT 图像之间的叠加误差。根据 PET 和 CT 图像之间的平均距离测量的拟合精度在 2 - 5 mm 范围内。 PET-CT 叠加图像产生肿瘤 FDG 摄取增加的定位，并且腭扁桃体的 FDG 摄取也被定位。此处描述的用于 PET 和 CT 图像对齐的标记系统可以在常规基础上使用，无需侵入性固定外部标记，改善头颈癌患者的管理和随访。