Research on the pathogenesis and treatment of Epstein-Barr virusassociated intractable diseases

EB病毒相关疑难杂症的发病机制及治疗研究

• 批准号: 21591388
• 负责人: OHGA Shouichi
• 金额: $ 2.91万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591388/
• 关键词: 小児感染症学; EBウイルス; リンパ増殖性疾患; 血球貪食症候群; 免疫化学療法; 造血細胞移植

In patients with chronic active Epstein-Barr virus infection(CAEBV) or EBVassociated hemophagocytic syndrome(EBV-HLH), EBVpositive T/NK cells were suggested to arise from hematopoietic progenitors and need CD4positive cells for the clonal proliferation in a distinct manner from tumorigenesis. Early immunomodulatory therapy effectively controlled EBV-HLH in children with primary infection. Long-term outcomes of pediatric patients were favorable after hematopoietic stem cell transplantation, while adult patients had poor outcomes. Characterization of EBVinfected T/NK cells is critical for the establishment of treatment strategy.

在患有慢性活性爱泼斯坦 - 巴尔病毒感染（CAEBV）或EBVASSICAPIC造血综合征（EBV-HLH）的患者中，建议提出EBVP阳性T/NK细胞是由造血祖细胞引起的，并且需要CD4PORSITIVE CD4PORSITIVE细胞以与tumorigeneSease的不同方式以分布型的细胞增殖。早期免疫调节疗法可有效控制原发性感染儿童的EBV-HLH。小儿患者的长期结局在造血干细胞移植后是有利的，而成年患者的预后较差。 EBVINCTED T/NK细胞的表征对于建立治疗策略至关重要。

项目成果

Recurrent atrial fibrillation after high-dose methylprednisolone therapy in a girl with lupus-associated hemophagocytic syndrome

一名患有狼疮相关噬血细胞综合征的女孩接受大剂量甲泼尼龙治疗后复发性房颤

• DOI: 10.1177/0961203310392429
• 发表时间: 2011
• 期刊: Lupus
• 影响因子: 2.6
• 作者: Yamamura K;Ohga S;Nishiyama K;Doi T;Tsutsumi Y;Ikeda K;Fujishima A;Takada H;Hara T
• 通讯作者: Hara T

Differential transmission and postnatal outcome in triplets with congenital cytomegalovirus infection

先天性巨细胞病毒感染三胞胎的差异传播和产后结局

• DOI: 10.2350/11-05-1034-cr.1
• 发表时间: 2011
• 期刊: Pediatr Development Pathol
• 作者: Kitajima J;Inoue H;Ohga S;Kinjo T;Ochiai M;Yoshida T;Kusuhara K;Hara T
• 通讯作者: Hara T

Nationwide Survey of Single-System Single Site Langerhans Cell Histiocytosis in Japan

• DOI: 10.1002/pbc.22224
• 发表时间: 2010-01-01
• 期刊: PEDIATRIC BLOOD & CANCER
• 影响因子: 3.2
• 作者: Morimoto, Akira;Ishida, Yasushi;Ishii, Eiichi
• 通讯作者: Ishii, Eiichi

Recurrentat riall fibrillation after high-dose methylprednisolone therapy in a girl with lupusassociated hemophagocytic syndrome

狼疮相关噬血细胞综合征女孩大剂量甲泼尼龙治疗后复发性房颤

• 发表时间: 2011
• 期刊: Lupus
• 影响因子: 2.6
• 作者: Yamamura K;Ohga S;Nishiyama K;Doi T;Tsutsumi Y;Ikeda K;Fujishima A;Takada H;Hara T
• 通讯作者: Hara T

Clonal origin of EBVinfected T/NK-cell subpopulations in chronicactive Epstein-Barr virus infection

慢性活动性 Epstein-Barr 病毒感染中 EBV 感染的 T/NK 细胞亚群的克隆起源

• 发表时间: 2010
• 作者: Ohga S;Takada H;Abe Y;Miyamoto T;Akashi K;Ohshima K;Hara T
• 通讯作者: Hara T