Molecular mechanism of pathogenic chlamydial infection to lymphocytes

致病性衣原体感染淋巴细胞的分子机制

• 批准号: 21590474
• 负责人: YAMAGUCHI Hiroyuki
• 金额: $ 3万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590474/
• 关键词: Chlamydophila pneumoniae; リンパ球細胞; IFNγ; 付着; ヘパリン; グランザイムK; 肺炎クラミジア; グランザイム; エフェクター蛋白; 外膜蛋白; ストレス蛋白GroEL1; 持続感染

We assessed pathogenic chlamydial infection mechanism to lymphocytes when compared to epithelial cells. As a result, we found the unique chlamydial attachment process on lymphocytes, independent of heparin, which has a critical on bacterial general attachment to cells. It was also confirmed by using DNA microarray that pathogenic chlamydial survival in lymphocytes was controlled by granzyme K. Furthermore, we demonstrated that lymphocytes could provide a shelter for pathogenic chlamydiae to escape from IFNγ. Thus, pathogenic chlamydial infection mechanism to lymphocytes is unique when compared to epithelial cells, possibly connecting clinical significance.

我们在淋巴细胞上与淋巴细胞相比，评估了致病性衣原体机械，与肝素无关。致病性衣原体的遮盖物因此，淋巴细胞的致病性衣原体感染机制是独一无二的。

项目成果

Phenotypic Properties in Amoebae Controlled by Environmental Chlamydia

环境衣原体控制的变形虫表型特性

• 发表时间: 2011
• 作者: Okude M;Matsuo J;Nakamura S;Hayashi Y;Yoshida Y;Yoshida M;Takahashi K;Yamaguchi H
• 通讯作者: Yamaguchi H

環境クラミジアProtochlamydiaはヒト上皮系細胞株HEp-2細胞に対してミトコンドリアを介してアポトーシスを誘導する

环境衣原体原衣原体通过线粒体诱导人上皮细胞系 HEp-2 细胞凋亡

• 发表时间: 2012
• 作者: 松尾淳司;伊藤敦巳;中村眞二;山口博之
• 通讯作者: 山口博之

ヒト生殖器スワブからの環境クラミジアParachlamydia acanthamoebae 遺伝子の検出

人类生殖拭子中环境衣原体棘阿米巴副衣原体基因的检测

• 发表时间: 2011
• 作者: 福元達也;松本めぐみ;林 泰弘;秋沢宏次;清水 力;松野一彦;阿部清孝;南 邦弘;山口博之
• 通讯作者: 山口博之

A domino-like chlamydial attachment process : Parachlamydia acanthamoebae attachment to amoebae is concurrently required for several amoebal released molecules and serine-protease activity

多米诺骨牌样衣原体附着过程：棘阿米巴副衣原体附着到变形虫上，同时需要几种变形虫释放的分子和丝氨酸蛋白酶活性

• 发表时间: 2012
• 期刊: Microbiology
• 影响因子: 1.5
• 作者: Hayashi Y;Yimin;Matsuo J;Nakamura S;Kunichika M;Yoshida M;Takahashi K;Yamaguchi H
• 通讯作者: Yamaguchi H

Ciliates Promote Gene Transfer Between Escherichia coli Strains Through Bacterial Accumulation in Vesicles

纤毛虫通过囊泡中的细菌积累促进大肠杆菌菌株之间的基因转移

• 发表时间: 2010
• 作者: Oguri S;et al
• 通讯作者: et al