Prevalence of H. pylori Infection and Chronic Atrophic Gastritis in the Dominican Children

多米尼加儿童幽门螺杆菌感染和慢性萎缩性胃炎的患病率

• 批准号: 20590606
• 负责人: AOKI Kazuo
• 金额: $ 3万
• 依托单位: University of the Ryukyus
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590606/
• 关键词: ヘリコバクター・ピロリ(H.pylori)感染; 胃がん; 慢性萎縮性胃炎; ドミニカ共和国; ペプシノゲン; ガストリン; CagA抗体; 疫学; ヘリコバクタ・ピロリ感染; 小児; CagA; 生活習慣; 生活環境; Cag A

TITLE : Prevalence of H. pylori Infection and Chronic Atrophic Gastritis in the Dominican ChildrenPURPOSE : To show the prevalence of H. pylori infection and chronic atrophic gastritis (CAG) and the positivity of CagA antibody to H. pylori in the Dominican children, and to clarify the several factors that related to H. pylori infection and CAG by multivariate analysis.METHODS : One thousand and thirty one subjects who have given us the informed consent in writing were volunteers from children of the nursery school, a kindergarten, a primary school, and a junior high school in the Dominican Republic. Each individual underwent a health checkup and blood sampling for measurement of serum pepsinogen I and II, pepsinogen I/II ratio, serum gastrin, H. pylori antibodies, and CagA antibody to H. pylori, and responded to a questionnaire on upper digestive tract diseases.RESULTS : The prevalence of H. pylori infection (0.000-0.467) and CAG (0.000-0.158) varied by age and sex. The positivity of C … More agA antibody to H. pylori for boys and girls increased by advancing age in the Dominican children.To show the factors related to be H. pylori infection was done the stepwise regression analysis using forward likelihood procedure and choosing H. pylori infection as the dependent variable. The model included twenty-five independent variables (gastrointestinal disease-related subjective symptom, past history, and family history, environment, lifestyle, gender and age, and subjects examined data ; serum gastrin level. In this final step of the logistic regression model, of the subjects without H. pylori infection, 93.5% were correctly classified. Of the subjects with H. pylori infection, 27.7% were correctly classified. Overall, 75.6% of all subjects were correctly classified. The odds ratio of H. pylori infection in male subjects was 1.465 to female subjects. The odds ratio of H. pylori infection was 1.326 when age of the subject increase one year old. The odds ratio of H. pylori infection was 1.185 when numbers of children who live together increase one person. The odds ratio of H. pylori infection in subjects with diarrhea as subjective symptom was 1.567 to those without diarrhea. The odds ratio of H. pylori infection was 1.008 when serum gastrin level of the subject increases 1 pg/ml.To clarify the factors related to be chronic atrophic gastritis (CAG) was done the stepwise regression analysis using forward likelihood procedure and choosing chronic atrophic gastritis (CAG) as the dependent variable. The model included nine independent variables (gastrointestinal disease-related subjective symptom, past history, and family history, environment, lifestyle, gender, and age, subjects examined data; serum gastrin level, H. pylori infection, and antibody of CagA to H. pylori). In this final step of the logistic regression model, of the subjects without CAG, 99.0% were correctly classified. Of the subjects with CAG, 18.5% were correctly classified. Overall, 88.0% of all subjects were correctly classified. The odds ratio of CAG was 1.006 when serum gastrin level of the subject increased 1 pg/ml. The odds ratio of CAG in subjects with antibody of CagA to H. pylori infection was 2.090 to those without antibody of CagA. The odds ratio of CAG in subjects with H. pylori infection was 2.738 to those without H. pylori infection.The Cross tabulation by gender between H. pylori infection and antibody of CagA to H. pylori showed it that the positivity of CagA antibody has not seen significant differences between boys and girls. However, the positivity of CagA antibody was about 20 % by our CagA measurement kit in subjects1 who have had no H. pylori infection.CONCLUSIONS :Our results indicated that serum gastrin, CagA antibody to H. pylori, and H. pylori infection are a good marker of CAG even in children. To clarify the relationship between the positivity of CagA antibody to H. pylori and chronic atrophic gastritis need further study. Less

标题：多米尼加儿童中幽门螺杆菌感染和慢性萎缩性胃炎的患病率：显示幽门螺杆菌感染和慢性萎缩性胃炎（CAG）的患病率（CAG）的患病率（CAG）以及CAGA抗体对多数氏犬的阳性和CAGA抗体的阳性，并使多个因素与Dominican Inficiation Carlifife Multiv Carlife Carlifife Multiv Carlife and callor and callor and callor and callor and and an。分析方法：授予我们书面知情同意的一千和三十一名是来自托儿所的孩子，幼儿园，小学和多米尼加共和国的一所初中的志愿者。每个人都进行了健康检查和血液采样，以测量血清胃蛋白酶原I和II，倍蛋皮蛋皮蛋皮蛋白酶原I/II比，血清胃胃，H。Pylori抗体和伴随幽门螺杆菌的CAGA抗体，并响应上消化型疾病的问卷。 （0.000-0.467）和CAG（0.000-0.158）因年龄和性别而异。 C…对幽门螺杆菌对男孩和女孩的更多Aga抗体的阳性通过提高多米尼加儿童的年龄而增加。要显示与幽门螺杆菌感染相关的因素进行了使用正向的可能性过程进行逐步回归分析，并选择H.幽门杆菌感染作为因变量。该模型包括二十五个自变量（胃肠道与疾病相关的受试者，过去的病史以及家族史，环境，生活方式，性别，性别和年龄以及检查数据的受试者；血清胃癌水平。在逻辑回归模型的这一最后一步中，没有幽门螺杆菌感染的主题，得33.5％的受试者是正确的。总体而言，所有受试者中有75.6％的人是幽门螺杆菌感染的几率。腹泻作为主观症状的受试者对没有腹泻的受试者为1.567。作为因变量。该模型包括九个独立变量（胃肠道疾病相关的主体符号，过去的历史和家族史，环境，生活方式，性别和年龄，受试者检查了数据；血清胃胃含量，幽门螺杆菌感染以及caga抗体对H.幽门的抗体）。在逻辑回归模型的最后一步中，没有CAG的受试者，有99.0％的人正确分类。在具有CAG的受试者中，正确分类了18.5％。总体而言，所有受试者中有88.0％正确分类。当受试者的血清胃泌素水平增加1 pg/mL时，CAG的优势比为1.006。 CAGA抗体与幽门螺杆菌感染的受试者中CAG的优势比为2.090，而没有CAGA的抗体。幽门螺杆菌感染的受试者中CAG的几率比没有幽门螺杆菌感染的患者为2.738。幽门螺杆菌感染与幽门螺杆菌的抗体之间的性别交叉表相交表明，CAGA抗体对男孩和女孩之间的阳性没有显着差异。然而，在没有幽门螺杆菌感染的受试者中，我们的CAGA测量试剂盒的CAGA抗体的阳性约为20％。结论：我们的结果表明，血清胃胃抗体，与幽门螺杆菌的Caga抗体和幽门螺杆菌感染的抗体是CAG的良好标志。为了阐明CAGA抗体对幽门螺杆菌的阳性与慢性萎缩性胃炎之间的关系。较少的

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在感染幽门螺杆菌的老年蒙古沙鼠中长期用饮用水给予杂斑半胱氨酸会增强胃粘膜的癌变。

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