Prevalence of H. pylori Infection and Chronic Atrophic Gastritis in the Dominican Children

多米尼加儿童幽门螺杆菌感染和慢性萎缩性胃炎的患病率

• 批准号: 20590606
• 负责人: AOKI Kazuo
• 金额: $ 3万
• 依托单位: University of the Ryukyus
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590606/
• 关键词: ヘリコバクター・ピロリ(H.pylori)感染; 胃がん; 慢性萎縮性胃炎; ドミニカ共和国; ペプシノゲン; ガストリン; CagA抗体; 疫学; ヘリコバクタ・ピロリ感染; 小児; CagA; 生活習慣; 生活環境; Cag A

TITLE : Prevalence of H. pylori Infection and Chronic Atrophic Gastritis in the Dominican ChildrenPURPOSE : To show the prevalence of H. pylori infection and chronic atrophic gastritis (CAG) and the positivity of CagA antibody to H. pylori in the Dominican children, and to clarify the several factors that related to H. pylori infection and CAG by multivariate analysis.METHODS : One thousand and thirty one subjects who have given us the informed consent in writing were volunteers from children of the nursery school, a kindergarten, a primary school, and a junior high school in the Dominican Republic. Each individual underwent a health checkup and blood sampling for measurement of serum pepsinogen I and II, pepsinogen I/II ratio, serum gastrin, H. pylori antibodies, and CagA antibody to H. pylori, and responded to a questionnaire on upper digestive tract diseases.RESULTS : The prevalence of H. pylori infection (0.000-0.467) and CAG (0.000-0.158) varied by age and sex. The positivity of C … More agA antibody to H. pylori for boys and girls increased by advancing age in the Dominican children.To show the factors related to be H. pylori infection was done the stepwise regression analysis using forward likelihood procedure and choosing H. pylori infection as the dependent variable. The model included twenty-five independent variables (gastrointestinal disease-related subjective symptom, past history, and family history, environment, lifestyle, gender and age, and subjects examined data ; serum gastrin level. In this final step of the logistic regression model, of the subjects without H. pylori infection, 93.5% were correctly classified. Of the subjects with H. pylori infection, 27.7% were correctly classified. Overall, 75.6% of all subjects were correctly classified. The odds ratio of H. pylori infection in male subjects was 1.465 to female subjects. The odds ratio of H. pylori infection was 1.326 when age of the subject increase one year old. The odds ratio of H. pylori infection was 1.185 when numbers of children who live together increase one person. The odds ratio of H. pylori infection in subjects with diarrhea as subjective symptom was 1.567 to those without diarrhea. The odds ratio of H. pylori infection was 1.008 when serum gastrin level of the subject increases 1 pg/ml.To clarify the factors related to be chronic atrophic gastritis (CAG) was done the stepwise regression analysis using forward likelihood procedure and choosing chronic atrophic gastritis (CAG) as the dependent variable. The model included nine independent variables (gastrointestinal disease-related subjective symptom, past history, and family history, environment, lifestyle, gender, and age, subjects examined data; serum gastrin level, H. pylori infection, and antibody of CagA to H. pylori). In this final step of the logistic regression model, of the subjects without CAG, 99.0% were correctly classified. Of the subjects with CAG, 18.5% were correctly classified. Overall, 88.0% of all subjects were correctly classified. The odds ratio of CAG was 1.006 when serum gastrin level of the subject increased 1 pg/ml. The odds ratio of CAG in subjects with antibody of CagA to H. pylori infection was 2.090 to those without antibody of CagA. The odds ratio of CAG in subjects with H. pylori infection was 2.738 to those without H. pylori infection.The Cross tabulation by gender between H. pylori infection and antibody of CagA to H. pylori showed it that the positivity of CagA antibody has not seen significant differences between boys and girls. However, the positivity of CagA antibody was about 20 % by our CagA measurement kit in subjects1 who have had no H. pylori infection.CONCLUSIONS :Our results indicated that serum gastrin, CagA antibody to H. pylori, and H. pylori infection are a good marker of CAG even in children. To clarify the relationship between the positivity of CagA antibody to H. pylori and chronic atrophic gastritis need further study. Less

标题：多米尼加儿童幽门螺杆菌感染和慢性萎缩性胃炎的患病率 目的：显示多米尼加儿童幽门螺杆菌感染和慢性萎缩性胃炎 (CAG) 的患病率以及幽门螺杆菌 CagA 抗体的阳性情况，以及通过多因素分析阐明与H. pylori感染和CAG相关的几个因素。方法：1031名已向我们提供知情的受试者来自多米尼加共和国幼儿园、幼儿园、小学和初中的儿童志愿者均签署了书面同意书，对每个人进行了健康检查和血液采样，以测量血清胃蛋白酶原I和II、胃蛋白酶原I/。 II比值、血清胃泌素、H. pylori抗体、H. pylori CagA抗体，并回答上消化道疾病调查问卷。 结果：H. pylori感染患病率(0.000-0.467) 和 CAG (0.000-0.158) 因年龄和性别而异。 多米尼加儿童中男孩和女孩的幽门螺杆菌 C agA 抗体阳性率随着年龄的增长而增加。使用正向似然法并选择幽门螺杆菌感染作为变量，对幽门螺杆菌感染进行逐步回归分析。该模型包括二十五个自变量（胃肠道）。疾病相关的主观症状、既往病史、家族史、环境、生活方式、性别和年龄以及受试者检查的数据；在逻辑回归模型的最后一步中，没有幽门螺杆菌感染的受试者为93.5。幽门螺杆菌感染的受试者中有 27.7% 被正确分类。总体而言，男性受试者中幽门螺杆菌感染的比值比为 75.6%。女性受试者年龄增加一岁时，幽门螺杆菌感染的几率为1.326；当共同居住的儿童数量增加1人时，幽门螺杆菌感染的几率为1.185。当血清胃泌素水平为1.008时，以腹泻为主观症状的受试者与无腹泻的受试者相比，幽门螺杆菌感染的优势比为1.008。受试者增加 1 pg/ml。为了澄清与慢性萎缩性胃炎 (CAG) 相关的因素，使用前向似然程序进行逐步回归分析，并选择慢性萎缩性胃炎 (CAG) 作为因变量。该模型包括九个自变量。 （胃肠道疾病相关主观症状、既往史、家族史、环境、生活方式、性别、年龄、受试者检查资料；血清胃泌素水平、H. pylori感染情况、H. pylori CagA抗体等。在逻辑回归模型的最后一步中，在没有 CAG 的受试者中，有 99.0% 的受试者被正确分类。总体而言，有 88.0% 的受试者被正确分类。当受试者的血清胃泌素水平增加1pg/ml时，CAG的比率为1.006。具有CagA抗幽门螺杆菌感染的抗体的受试者中CAG的比值比为1.006。 H. pylori 感染者与无 CagA 抗体者的比值比为 2.090。H. pylori 感染者与 CagA 抗 H. pylori 抗体者的性别比值比为 2.738。男孩和女孩的 CagA 抗体阳性率没有显着差异，但我们的 CagA 检测试剂盒在受试者中的 CagA 抗体阳性率约为 20%1。结论：我们的结果表明，血清胃泌素、幽门螺杆菌 CagA 抗体和幽门螺杆菌感染是 CAG 的良好标志，即使在儿童中也是如此，以阐明 CagA 抗体阳性之间的关系。 H. pylori与慢性萎缩性胃炎的关系还需进一步研究。

项目成果

'Caribbean Wonder'を解明するために～日本、中国、タンザニア、及びドミニカ共和国のヘリコバクター・ピロリ感染と慢性萎縮性胃炎～

阐明“加勒比奇迹”——日本、中国、坦桑尼亚和多米尼加共和国的幽门螺杆菌感染和慢性萎缩性胃炎——

• 发表时间: 2008
• 作者: 和田悦子;岡田隆;山崎雅之;岩本麻実子;塩飽邦憲;里見佳子;青木一雄
• 通讯作者: 青木一雄

農村医学への提言「南部スーダン戦略的保健医療人材育成プロジェクトを開始して

对农村医学的建议：“启动苏丹南部战略卫生保健人力资源开发项目”

• 发表时间: 2010
• 期刊: 九州農村医学会雑誌 19&20
• 作者: 佐藤素子;塩飽邦憲;Nishino Hoyoku;青木一雄
• 通讯作者: 青木一雄

Long-term administration of sterigumatocystin with drinking water in Helicobacter pylori-infected aged Mongolian gerbils enhances carcinogenesis in the gastric mucosa.

在感染幽门螺杆菌的老年蒙古沙鼠中长期用饮用水给予杂斑半胱氨酸会增强胃粘膜的癌变。

• 发表时间: 2009
• 期刊: Journal of Physical Fitness, Nutrition and Immunology 19
• 作者: Kusunoki M;Misumi J;Aoki K;Shimada T;Matsuo N;Sumiyoshi H;Ebine N;Yamaguchi T;Okamoto A;Yoshioka H.
• 通讯作者: Yoshioka H.

新農村保健

新农村健康

• 发表时间: 2008
• 作者: 明石光伸;上田厚;青木一雄;他,編著
• 通讯作者: 他,編著

Helicobacter pylori infection and chronic atrophic gastritis in East Asia, the tropics, and the subtropics～A clue to solve "Asian paradox","African enigma" and "Caribbean wonder" based on the field studies in Japan, China

东亚、热带、亚热带的幽门螺杆菌感染与慢性萎缩性胃炎～基于日本、中国的实地调查，解决“亚洲悖论”、“非洲之谜”、“加勒比奇迹”的线索

• 发表时间: 2008
• 期刊: Tanzania, and the Dominican Republic～Ryukyu Medical Journal 27
• 作者: Yamasaki M;Anuurad E;Schachter N;Berglund L;Aoki K.
• 通讯作者: Aoki K.