Effect on life style to Helicobacter pylori infection and/or chronic atrophic gastritis in the tropics

热带地区生活方式对幽门螺杆菌感染和/或慢性萎缩性胃炎的影响

基本信息

批准号：
17590518
负责人：
AOKI Kazuo
金额：
$ 2.24万
依托单位：
Oita University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

项目摘要

Commurity-based study in which 478 inhabitants of the Dominican Republic answered detailed questionnaires on upper digestive tract diseases, and then underwent screening for chronic atrophic gastritis by serum pepsinogen and testing for serum gastrin and antibody to H. pylori. In adult's subjects, the prevalences of H. pylori infection were 61.1% and 64.7% for males and females, respectively. Also, the prevalences of chronic atrophic gastritis were 16.7% and 11.8% for males and females, respectively. There were no sex differences in the prevalences of H. pylori infection and those of chronic atrophic gastritis. Although no significant difference was seen in the prevalence of H. pylori infection between smoker and non smoker males, that of H. pylori in smoker females(91.7%) was higher than that in non-smoker females(60.3%).On the other hand, the prevalence of H. pylori increased with advancing age in the subjects less than 15 years old in the Dominican Republic, and they were 32.3%, 45.1%, and 56.0% in the age group of 0-5, 5-10, and 10-15 years of age.Logistic regression analysis with stepwise method using forward likelihood procedure was conducted to assess the odds ratio of related factors to H. pylori infection or chronic atrophic gastritis for all 478 subjects. Three significant independent variables (sex, age, and serum gastrin concentration) were selected in the logistic regression model. The odds ratio of H. pylori infection in males was 0.595 times that in females. The odds ratio of H. pylori increased 3.2%/year in advancing age and 0.3%/1pg/ml increase in serum gastrin level. In the same way, after using logistic regression analysis to estimate the odds ratio of some factors to chronic atrophic gastritis, only one significant independent variable (serum gastrin concentration) was selected in this model. The odds ratio of chronic atrophic gastritis increased 0.9%/1pg/ml increase in serum gastrin level.

基于合理性的研究中，多米尼加共和国的478名居民回答了有关上部消化道疾病的详细问卷，然后通过血清胃蛋白酶原和对H. Pylori抗体的血清胃胃胃炎和抗体进行了慢性萎缩性胃炎的筛查。在成年人的受试者中，男性和女性的幽门螺杆菌感染的患病率分别为61.1％和64.7％。同样，男性和女性的慢性萎缩胃炎的患病率分别为16.7％和11.8％。幽门螺杆菌感染的患病率和慢性萎缩性胃炎的患病率没有性别差异。尽管吸烟者和非吸烟者男性之间幽门螺杆菌感染的患病率没有显着差异，但吸烟雌性中幽门螺杆菌的患病率（91.7％）高于非吸烟女性（60.3％）的幽门螺杆菌感染率（91.7％）。手中，多米尼加共和国不到15岁的受试者的年龄，幽门螺杆菌的患病率增加了，在0-5、5-10岁的年龄段中，幽门螺杆菌的患病率是32.3％，45.1％和56.0％进行了10-15岁的年龄。使用逐步方法进行了逐步的回归分析，使用正向可能性程序进行了逐步方法，以评估所有478名受试者的幽门螺杆菌感染或慢性萎缩性胃炎的相关因素的优势比。在逻辑回归模型中选择了三个显着的独立变量（性别，年龄和血清胃蛋白浓度）。雄性幽门螺杆菌感染的几率比女性的0.595倍。幽门螺杆菌的优势比增加了3.2％/年的增长年龄和0.3％/1pg/ml的血清胃胃水平增加。以同样的方式，在使用逻辑回归分析来估计某些因素与慢性萎缩性胃炎的几率之比之后，该模型仅选择了一个显着的自变量（血清胃蛋白浓度）。慢性萎缩性胃炎的优势比增加了0.9％/1pg/ml血清胃蛋白水平的增加。