Development of Gold-and Palladium-catalyzed New Transformations via Modification of Ligands

通过配体修饰开发金和钯催化的新转化

• 批准号: 20350015
• 负责人: YAMAMOTO Yoshinori
• 金额: $ 12.31万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20350015/
• 关键词: 反応有機化学; 金触媒; パラジウム触媒; リン配位子効果; ヒドロチオル化; 三成分環化反応; 連続的環化反応; D-A-D有機光電材料; 炭素-炭素多結合活性化; カチオン性金触媒; アレン化合物; アルキン化合物; よう素反応剤; 複素環; 不斉ヒドロアミノ化; アルキン; アレン; 不斉配位子

Novel Pd-and Au-catalyzed molecular transformations have been developed through the modification of ligands and counter anions which showed high reactivity and selectivity. A variety of Norbornane derivatives have been synthesized and successfully used in the Pd-catalyzed asymmetric intramolecular hydroamination of alkynes. The newly prepared (R, R)-methyl norphos and (R, R)-toly renorphos afforded N-containing heterocyles in high yields and high enantio-selectivity. Moreover, novel Pd-catalyzed allylative dearomatization and three-component cycloaddition were developed. We have succeeded in development of cationic Au-catalyzed hydroalkoxylation and hydrothiolation. Moreover, we also succeeded in construction of thienocarbazole frameworks via a new Au-catalyzed cascade cyclization of arydiynes, which was further applied in the synthesis of D-A-D organic electronic materials. Various O-, S-and N-containing heterocyles bearing diiodine substituents have been synthesized through the facile and efficient electrophilic iodocyclizations.

通过配体和抗衡阴离子的修饰，开发了新型钯和金催化的分子转化，具有高反应性和选择性。多种降冰片烷衍生物已被合成并成功用于钯催化的炔烃不对称分子内氢胺化反应。新制备的(R,R)-甲基去甲磷和(R,R)-甲基去甲磷以高产率和高对映选择性提供含氮杂环。此外，还开发了新型钯催化烯丙基脱芳构化和三组分环加成反应。我们成功开发了阳离子金催化的氢烷氧基化和氢硫醇化。此外，我们还通过新型Au催化芳基炔级联环化成功构建了噻吩并咔唑骨架，并进一步应用于D-A-D有机电子材料的合成。通过简单有效的亲电碘环化合成了各种带有二碘取代基的含O、S和N的杂环。

项目成果

π-Electrophilic Lewis Acids Catalyzed New transformations

π-亲电路易斯酸催化新转变

• 发表时间: 2009
• 作者: uchibe;K.; Mayumi;Y.; Wang;K.;Yokota;M.; Ichikawa;J;山本嘉則
• 通讯作者: 山本嘉則

Gold-catalyzed hydrofunctionalization of allenes with nitrogen and oxygen nucleophiles and its mechanistic insight

• DOI: 10.1016/j.tet.2008.11.106
• 发表时间: 2009-02
• 期刊: Tetrahedron
• 影响因子: 2.1
• 作者: Naoko Nishina;Yoshinori Yamamoto

Coinage Metal Catalyzed New Reactions

造币金属催化新反应

• 发表时间: 2008
• 作者: 後藤敬;青木洋平;吉川修平;三崎朋子;阿部憲明;佐瀬祥平;山本嘉則
• 通讯作者: 山本嘉則

Palladium-catalyzed bisfunctionalization of active alkenes by .-acetonitrile-allyl addition : application to the synthesis of unsymmetric 1, 4-di(organo)fullerene derivatives

钯催化的活性烯烃的.-乙腈-烯丙基加成双官能化：在不对称 1, 4-二（有机）富勒烯衍生物合成中的应用

• 发表时间: 2012
• 期刊: Tetrahedron Lett
• 影响因子: 1.8
• 作者: Lu Shirong;Jin Tienan;Bao Ming;Asiri Abdullah M.;Yamamoto Yoshinori
• 通讯作者: Yamamoto Yoshinori

シグマおよびパイ配位性ルイス酸を用いる分子変換

使用西格玛和皮配位路易斯酸进行分子转化

• 发表时间: 2010
• 作者: T. Yoshikawa;H. Motegi;A. Kakizaki;T. Takayanagi;M. Shiga;M. Tachikawa;Tetsu Kogiso;山本嘉則
• 通讯作者: 山本嘉則